Peripheral Primitive Neuroectodermal Tumors (Peripheral Neuroectodermal Tumor)
153
relevant articles (0 outcomes,
10 trials/studies)
found for this Disease
Description:
A group of highly cellular primitive round cell neoplasms which occur extracranially in soft tissue and bone and are derived from embryonal neural crest cells. These tumors occur primarily in children and adolescents and share a number of characteristics with Ewing's Sarcoma (SARCOMA, EWING'S). They may arise from the chest wall, skin, orbit, kidney, and other structures and tend to be locally invasive or metastasize, although relatively benign forms may occur. Characteristic histologic features include a tendency to form Homer-Wright rosettes and to stain positively with neuron-specific enolase and vimentin. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2113; J Clin Oncol 1998 Mar;16(3):1150-7)
Also Known As:
Peripheral Neuroectodermal Tumor; Neuroepithelioma; Neuroectodermal Tumors, Primitive, Peripheral; (pPNET) Peripheral Primitive Neuroectodermal Tumors; Extracranial Primitive Neuroectodermal Tumor; Neuroectodermal Neoplasm, Peripheral Primitive; Neuroectodermal Tumor, Peripheral Primitive; Peripheral Primitive Neuroectodermal Neoplasm; Primitive Neuroectodermal Tumor, Extracranial; Neuroectodermal Tumors, Peripheral; Neuroepitheliomas; Peripheral Neuroectodermal Tumors; Tumor, Peripheral Neuroectodermal; Tumors, Peripheral Neuroectodermal; Neuroectodermal Tumor, Peripheral
Disease Context: Research Results
Related Diseases
Experts
| 1. | Di Bartolomeo, S:
2 articles
(06/2002 - 04/2001)
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| 2. | Spinedi, A:
2 articles
(06/2002 - 04/2001)
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| 3. | Yeung, Wendy W S:
1 article
(09/2005)
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| 4. | Wong, Yung H:
1 article
(09/2005)
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| 5. | Chan, Anthony S L:
1 article
(09/2005)
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| 6. | Blum, Werner F:
1 article
(08/2005)
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| 7. | Kiess, Wieland:
1 article
(08/2005)
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| 8. | Kratzsch, Jürgen:
1 article
(08/2005)
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| 9. | Klammt, Jürgen:
1 article
(08/2005)
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| 10. | Seidel, Bertolt:
1 article
(08/2005)
|
Drugs and Biologics
Drugs and Important Biological Agents (IBA) related to Peripheral Primitive Neuroectodermal Tumors:
| 1. | DNA (Deoxyribonucleic Acid)IBA
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| 2. | AntigensIBA
01/01/1990
- " Moreover, it was found that GI-ME-N cells did not express N-myc oncogene or HLA class 1 antigens, and were not classified as peripheral neuroectodermal tumor cells" 04/01/1996
- " Immunostaining of the p30/32MIC2 antigen and molecular detection of EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral neuroectodermal tumor." 09/01/1989
- " Expression of a new human THY-1 related antigen in Ewing's sarcoma and peripheral neuroectodermal tumors." 01/01/1989
- " The monoclonal HBA-71 antibody recognizes a new human tumor-associated antigen of Ewing's sarcoma and peripheral neuroectodermal tumors, which is also expressed in some normal tissues, including thymus, islets of Langerhans, ependyme, adenohypophysis, Sertoli/Leydig and granulosa cells" 08/01/1994
- " To determine if T-cell-defined melanoma antigens are expressed on other tumors of neuroectodermal origin, four melanoma-specific cytotoxic T lymphocyte (CTL) cultures derived from tumor-infiltrating lymphocytes (TIL) were tested for lysis of a panel of 23 HLA-A2+ neuroectodermal tumor cell lines of various histologies, including retinoblastoma (1), neuroblastoma (8), neuroepithelioma (6), astrocytoma (2), neuroglioma (1), and Ewing's sarcoma (5)"
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| 3. | ParaffinIBA
08/01/2004
- " OBJECTIVE: To investigate the expression of EWS-FLI1/ERG fusion transcript resulting from t(11;12)(q24;12) in paraffin-embedded tissues and its diagnostic implication for Ewing's sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET)" 11/01/1992
- " To determine whether such analyses of peripheral primitive neuroectodermal tumors might yield similar results, formalin-fixed, paraffin-embedded tissue specimens from 19 peripheral primitive neuroectodermal tumors, each previously characterized by immunohistochemical or ultrastructural study, were assessed" 11/01/1988
- " A new cell line (SIM-1) was derived from a peripheral neuroectodermal tumor (PNET) and used for the production of a monoclonal antibody (HBA-71), which recognizes a novel cell surface antigen of ES- and PNET-derived cells and paraffin-embedded tumor sections" 09/17/2004
- " METHODS: The variety of fusion transcripts were detected in 103 cases of STS, including 30 cases of synovial sarcoma (SS), 15 cases of rhabdomyosarcoma (RMS), 25 cases of Ewing's sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET), 12 cases of dermatofibrosarcoma protuberans (DFSP), 14 cases of aveolar soft part sarcoma (ASPS), 3 cases of leiomyosarcoma (LMS), 2 cases of malignant fibrous histocytoma (MFH), and 2 cases of fibrosarcoma (FS); and 20 cases of control tumors by reverse transcription-polymerase chain reaction (RT-PCR) using formalin fixed, paraffin embedded specimens" 08/01/2004
- " Detection of EWS-FLI1 fusion transcript in Ewing's sarcoma/peripheral primitive neuroectodermal tumors by one-step RT-PCR using paraffin-embedded tissues]"
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| 4. | AntibodiesIBA
01/01/1991
- " These antibodies were used to screen six neuroblastoma cell lines and one neuroepithelioma cell line" 11/01/1987
- " Thus, antibodies to cytokeratin are useful to distinguish neuroepitheliomas from ependymomas." 04/01/2001
- " In the present study, DNA flow cytometry (FCM) and immunocytochemistry (ICC) with a selected panel of antibodies were performed on 51 cases of malignant tumors which were referred for fine-needle aspiration biopsy (FNAB) to our Department of Cytology for the last 2 yr. Twelve cases were diagnosed as neuroblastoma, 16 as Ewing's sarcoma, 2 as retinoblastoma, 5 as non-Hodgkin's lymphoma (NHL), 5 as rhabdomyosarcoma, 2 as peripheral neuroectodermal tumors (PNETs), and 8 as Wilms' tumor" 06/15/1989
- " The antibodies recognize a Mr 180,000 plasma membrane phosphoglycoprotein produced in increased amounts in SH-SY5Y/VCR as well as in vincristine-resistant human neuroepithelioma (MC-IXC/VCR), vinblastine-resistant human leukemia (CEM/VLB100), and actinomycin D- or vincristine-resistant Chinese hamster (DC-3F/AD X and DC-3F/VCRd-5L) cells, as compared to control cells"
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| 5. | Nerve Growth Factor (NGF)IBA
02/01/1990
- " All three neuroepithelioma cell lines and all nine neuroblastoma cell lines with amplified N-myc oncogene did not show any apparent NGF-induced differentiation" 02/01/1990
- " A series of neuroepithelioma and neuroblastoma cell lines were screened for nerve growth factor (NGF)-induced differentiation" 02/01/1990
- " Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines." 04/15/1995
- " Using two automated colorimetric assays for determinations of cell numbers, the present study demonstrates that a) different NB and neuroepithelioma cell lines show distinct responses, both qualitatively and quantitatively, to basic FGF (bFGF), NGF, and EGF; b) even closely related NB cell lines (e.g., SK-N-SH, SH-SY5Y, and SHEP) do not respond uniformly to these factors; c) responses of the two neuroepithelioma cell lines employed (SK-N-MC and CHP-100) differ, but match those of certain NB cell lines; and d) two growth factors, bFGF and EGF, may both stimulate or inhibit proliferation, depending on the cell line studied"
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| 6. | Phosphopyruvate Hydratase (Enolase)IBA
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| 7. |