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Endodermal Sinus Tumor (Endodermal Sinus Tumors)

An unusual and aggressive tumor of germ-cell origin that reproduces the extraembryonic structures of the early embryo. It is the most common malignant germ cell tumor found in children. It is characterized by a labyrinthine glandular pattern of flat epithelial cells and rounded papillary processes with a central capillary (Schiller-Duval body). The tumor is rarely bilateral. Before the use of combination chemotherapy, the tumor was almost invariably fatal. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1189)
Also Known As:
Endodermal Sinus Tumors; Yolk Sac Tumor; Tumor, Endodermal Sinus; Tumor, Yolk Sac; Tumors, Endodermal Sinus; Tumors, Yolk Sac; Yolk Sac Tumors
Networked: 590 relevant articles (31 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Embryonal Carcinoma
3. Choriocarcinoma
4. Germinoma
5. Teratoma (Teratoid Tumor)

Experts

1. Ulbright, Thomas M: 8 articles (07/2014 - 04/2004)
2. Young, Robert H: 5 articles (08/2015 - 01/2004)
3. Cao, Dengfeng: 4 articles (01/2013 - 10/2009)
4. Cheng, Liang: 4 articles (02/2012 - 11/2004)
5. Nicholson, James C: 3 articles (01/2015 - 04/2010)
6. Allan, Robert W: 3 articles (05/2011 - 10/2009)
7. Peng, Yan: 3 articles (05/2011 - 10/2009)
8. Li, Jianping: 3 articles (05/2011 - 10/2009)
9. Heikinheimo, Markku: 3 articles (08/2010 - 01/2002)
10. Wei, Guanghui: 2 articles (11/2015 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Endodermal Sinus Tumor:
1. Cisplatin (Platino)FDA LinkGeneric
2. alpha-Fetoproteins (AFP)IBA
3. Bleomycin (Blenoxane)FDA LinkGeneric
4. Etoposide (VP 16)FDA LinkGeneric
5. Vinblastine (Vinblastine Sulfate)FDA Link
6. GlypicansIBA
7. VAC protocolIBA
8. Cyclophosphamide (Cytoxan)FDA LinkGeneric
9. PlatinumIBA
10. Alkaline PhosphataseIBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Combination Drug Therapy (Combination Chemotherapy)
3. Radiotherapy
4. Lymph Node Excision (Lymph Node Dissection)
5. Adjuvant Chemotherapy