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Seminoma

A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
Also Known As:
Seminomas
Networked: 2784 relevant articles (178 outcomes, 279 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
3. Neoplasm Metastasis (Metastasis)
4. Carcinoma (Carcinomatosis)
5. Embryonal Carcinoma

Experts

1. Looijenga, Leendert H J: 23 articles (08/2021 - 02/2002)
2. Bokemeyer, Carsten: 21 articles (12/2022 - 04/2002)
3. Dieckmann, Klaus-Peter: 21 articles (01/2022 - 03/2005)
4. Warde, Padraig: 17 articles (03/2018 - 11/2002)
5. Albers, Peter: 16 articles (12/2022 - 09/2002)
6. Chieffi, Paolo: 16 articles (11/2021 - 03/2005)
7. Heidenreich, Axel: 15 articles (04/2022 - 05/2004)
8. Schorle, Hubert: 14 articles (04/2022 - 09/2007)
9. Ulbright, Thomas M: 14 articles (01/2019 - 05/2002)
10. Cheng, Liang: 13 articles (10/2022 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Seminoma:
1. Carboplatin (JM8)FDA LinkGeneric
2. Cisplatin (Platino)FDA LinkGeneric
3. Etoposide (VP 16)FDA LinkGeneric
01/01/2023 - "Daily oral etoposide therapy produced encouraging efficacy results in patients with relapsed non-seminoma GCT (NSGCT) who completed HDCT and PBSCT and achieved complete serologic remission and hematologic recovery. "
09/01/2010 - "Four years before, he had received combination chemotherapy including etoposide for seminoma. "
01/01/1992 - "Thus there appears to be a contradictory debate; in the absence of precise staging of "thymic type" tumour and of randomised trials made difficult by the small number of cases one can envisage the following option: In the case of an inoperable T radiotherapy alone, excepting in the very bulky forms (diameter greater than 50% of the chest) or metastases where primary chemotherapy (CT) (4 cycles of VP16-platine) has a place: The treatment of the residual mass after CT depends on the size of the latter: less than 3 or equal to 3 cm by complementary treatment and greater than 3 cm by secondary surgery and if the seminoma is active complementary.(ABSTRACT TRUNCATED AT 250 WORDS)"
05/01/1994 - "The confirmation of the occurrence of acute myeloid leukemia as a late effect of etoposide and stomach cancer as a late effect of radiotherapy for stage I seminoma has drawn attention to the need to reduce treatment in good-risk patients. "
06/01/2011 - "To evaluate rates of complete remission and overall survival for patients with relapsed pure seminoma treated with high-dose carboplatin and etoposide followed by peripheral blood stem cell transplant. "
4. PlatinumIBA
5. Keratins (Keratin)IBA
6. Bleomycin (Blenoxane)FDA LinkGeneric
7. Monoclonal AntibodiesIBA
8. Tumor Biomarkers (Tumor Markers)IBA
9. AntibodiesIBA
10. Proteins (Proteins, Gene)FDA Link

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Orchiectomy (Orchidectomy)
4. Therapeutics
5. Lymph Node Excision (Lymph Node Dissection)