|3.||Endodermal Sinus Tumor (Endodermal Sinus Tumors)
|5.||Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
|1.||Ulbright, Thomas M: 8 articles (07/2014 - 04/2004)|
|2.||Spinella, Michael J: 8 articles (01/2012 - 04/2002)|
|3.||Cheng, Liang: 8 articles (05/2011 - 07/2004)|
|4.||Looijenga, Leendert H J: 6 articles (02/2011 - 02/2002)|
|5.||Biermann, Katharina: 5 articles (02/2011 - 09/2007)|
|6.||Gillis, Ad J M: 5 articles (02/2011 - 02/2002)|
|7.||Rajpert-De Meyts, Ewa: 4 articles (12/2014 - 07/2006)|
|8.||Schorle, Hubert: 4 articles (01/2013 - 09/2007)|
|9.||Bosl, George J: 4 articles (01/2012 - 07/2003)|
|10.||Freemantle, Sarah J: 4 articles (06/2011 - 04/2002)|
|1.||Cisplatin (Platino)FDA LinkGeneric
05/01/2014 - "In this study, we found that miR-383 inhibited the focal formation and abundance of γH2AX, which is the major marker of sites of DNA damage, with or without ultraviolet irradiation and cisplatin in testicular embryonal carcinoma (NT-2) cells. "
08/03/2012 - "Blockade of Noxa reduced the apoptotic response of embryonal carcinoma (EC) NTERA2 cells to cisplatin. "
01/01/2012 - "Herein, we have examined the proficiency of five embryonal carcinoma (EC) cell lines to repair cisplatin-induced ICLs. "
03/01/2002 - "Cisplatin-induced in vivo differentiation of human embryonal carcinoma."
05/03/2001 - "This indicates that RA and cisplatin responses may share a common pathway involving p53 in embryonal carcinomas. "
09/01/1996 - "It may be associated with high serum levels of AFP and/or HCG, but not when the embryonal carcinoma is really pure. "
09/01/1995 - "While in treatment, he underwent residual orbital mass resection, and the histologic diagnosis was embryonal carcinoma based on alpha-fetoprotein immunoperoxidase staining. "
01/01/1991 - "Alpha-fetoprotein is usually a reliable marker for endodermal sinus tumours and embryonal carcinomas, and also predicts the presence of yolk sac elements in mixed germ cell tumours. "
11/01/1987 - "Serial changes in serum alpha-fetoprotein (AFP) levels during treatment were studied among 27 patients with ovarian embryonal carcinoma. "
08/01/1987 - "Our experimental data suggest that AFP production in embryonal carcinomas is due to the functional expression of yolk sac differentiation preceding its morphologic expression. "
06/01/2006 - "Twenty-five cases of metastatic embryonal carcinoma after chemotherapy were immunohistochemically analyzed for CD30, OCT4, and cytokeratin AE1/AE3 expression. "
09/01/1984 - "These results indicate that the presence or absence of keratin by immunocytochemical methods can be helpful in distinguishing seminoma from embryonal carcinoma."
09/01/2007 - "The most significant difference between seminomas and embryonal carcinomas was the expression of spermatogenesis-associated genes (PRAME, MAGEA4, SPAG1, HPX) in seminomas and regulatory genes DNMT3B and SOX2 as well as small molecular weight keratins KRT8, KRT18 in embryonal carcinomas. "
07/01/1993 - "Immunocytochemically, four of these tumors suggested some progression towards the embryonal carcinoma phenotype on the basis of cytokeratin expression. "
09/01/1987 - "Syncytial trophoblastic cells reactive for cytokeratin were identified in all choriocarcinomas, 12 embryonal carcinomas, and two seminomas. "
|4.||Tretinoin (Retinoic Acid)FDA LinkGeneric
02/24/2005 - "We have previously shown that p53 repression in TGCT-derived human embryonal carcinoma (EC) is relieved upon treatment with all-trans retinoic acid (RA), resulting in enhanced p53 transactivation activity. "
01/01/2011 - "To study the molecular basis of neurogenic properties of Gli2, we used a well-established embryonic stem cell model, the P19 embryonal carcinoma (EC) cell line, which can be induced to differentiate into neurons in the presence of retinoic acid (RA). "
01/01/2010 - "The aim of our study was to characterize mouse embryonal carcinoma (EC) cells P19 in different stages of retinoic acid induced neurodifferentiation by two methods, immunocytochemistry and RT qPCR. "
08/15/1996 - "The F9 murine embryonal carcinoma (EC) cell line, a well established model system for the study of retinoic acid (RA)-induced differentiation, differentiates into cells resembling three types of extra-embryonic endoderm (primitive, parietal and visceral), depending on the culture conditions and RA concentration used. "
01/01/1994 - "Previous studies have shown that the expression of some human HOX genes can be induced by retinoic acid (RA) in cultured embryonal carcinoma (EC) cells. "
|5.||Transcription Factors (Transcription Factor)IBA
01/01/2014 - "Human Nanog1 is a 305-amino acid (aa) homeodomain-containing transcription factor critical for the pluripotency of embryonic stem (ES) and embryonal carcinoma (EC) cells. "
12/01/2007 - "CIS/ITGCNU and seminomatous cells are characterized by expression of OCT3/4 and NANOG, while in addition embryonal carcinoma expresses SOX2, all identified as transcription factors related to pluripotency in embryonic stem (ES) cells. "
05/25/1990 - "The embryonal carcinoma stem cell Ela-like activity involves a differentiation-regulated transcription factor."
12/01/1993 - "In this study, we demonstrated the extinction of expression of the PU.1/Sfpi-1 putative oncogene encoding a B-cell- and macrophage-specific transcription factor when plasmacytoma cells are fused with embryonal carcinoma (EC) cells. "
01/01/2014 - "As such, SOX2 is an oncogenic transcription factor and crucial cancer stem cell (CSC) biomarker in embryonal carcinoma and, as more recently found, in the stem-like cancer cell component of many other malignancies. "
|6.||Nonseminomatous germ cell tumorIBA
08/01/1994 - "For nonseminomatous germ cell tumor, although all cellular components showed variable P53 expression, P53 expression in embryonal carcinoma constituents increased among stages of disease. "
01/15/1994 - "Vascular invasion and determination of percentage of embryonal carcinoma should be assessed for all clinical stage I nonseminomatous germ cell tumor patients and the model presented herein can be used clinically to predict the likelihood of occult disease and dictate therapy."
03/01/1998 - "With extended followup 74% of men with clinical stage I (T1) nonseminomatous germ cell tumor of the testis were cured by orchiectomy alone, and cure rates approached 90% when patients with predominant embryonal carcinoma histology or vascular invasion were excluded from surveillance. "
11/01/1993 - "The treatment of clinical stage I patients with nonseminomatous germ cell tumor with "surveillance only" may be contraindicated depending on features that include the proportion of embryonal carcinoma and the presence of lymphovascular invasion in the orchiectomy specimen. "
11/01/1985 - "In six primary intracranial non-seminomatous germ-cell tumors, there was weak positive staining indicating the presence of PLAP in only a few cells of one embryonal carcinoma, and in some glandular epithelial cells of one teratoma; this staining was limited to the cytoplasm. "
01/01/1992 - "Compared to the other antibodies tested, including the antibody against cytokeratins, in embryonal carcinoma immunohistochemical staining with 43-9F was more specific, stronger and more constantly expressed. "
09/01/2006 - "We conclude that immunostaining with antibodies to OCT4 is a useful diagnostic tool in the identification of seminomas and primary embryonal carcinomas in GCTs originating from the mediastinum."
07/01/2004 - "We conclude that immunostaining with antibodies to OCT4 is a useful diagnostic tool in the identification of primary testicular embryonal carcinomas and "usual," but not spermatocytic, seminomas. "
07/01/2004 - "Fifteen of the 54 germ cell tumors containing embryonal carcinoma were also examined with antibodies to CD30. "
10/01/1999 - "Antibodies to TNAP and PLAP/GCAP showed positivity in CIS, seminoma, and embryonal carcinoma. "
|8.||Surface Antigens (Surface Antigen)IBA
12/01/1983 - "Several days before the appearance of neurons, there is a marked decrease in the amount of an embryonal carcinoma surface antigen, and at the same time there is a substantial decrease in the volumes of individual cells. "
01/01/1986 - "Murine lymphocyte and embryonal carcinoma cell surface antigens recognised by rabbit anti-murine embryonal carcinoma serum."
05/01/1999 - "Human embryonal carcinoma (EC) cells typically require high cell densities to maintain their characteristic phenotype; they are generally subject to differentiation when cultured at low cell densities, marked by changes in morphology and expression of the surface antigen, SSEA-1. "
01/01/1984 - "Two monoclonal antibodies (TRA-1-60 and TRA-1-81) recognizing distinct cell surface antigens on human embryonal carcinoma (EC) cells were produced and characterized. "
12/01/1983 - "A monoclonal antibody reactive with an embryonal carcinoma-specific surface antigen was used to confirm the disappearance of undifferentiated cells after dimethyl sulfoxide treatment. "
11/01/1996 - "In addition, we eliminated the expression of vinculin in embryonal stem (ES) cells and in the embryonal carcinoma F9 line by gene disruption employing homologous recombination. "
04/01/2000 - "Vinculin's role was recently questioned by Goldberg [1997: Cell Motil Cytoskeleton 37:44-53] who observed Shigella motility in mouse embryonal carcinoma 5.51 cells, a genetically modified cell line that reputedly lacked vinculin. "
09/26/1995 - "To test the role of vinculin in cell adhesion and motility, we used homologous recombination to generate F9 embryonal carcinoma and embryonic stem cell clones homozygous for a disrupted vinculin gene. "
03/01/1983 - "Immunofluorescence and immunoblotting techniques were used to study the presence and distribution of vimentin and keratin type intermediate filaments, actin, and vinculin (130 kD protein) during retinoic acid (RA)-induced differentiation of F9 embryonal carcinoma (EC) cells. "
|10.||Mitomycin (Mitomycin-C)FDA LinkGeneric
04/01/1962 - "[Roentgenological study of embryonal carcinoma of the testis metastatic to the lungs cured by mitomycin C]."
05/01/1987 - "Many pluripotent embryonal carcinoma (EC) cell lines and all embryonic stem (ES) cell lines have hitherto been maintained in the undifferentiated state only by culture on feeder layers of mitomycin C-treated embryonic fibroblasts. "
|1.||Drug Therapy (Chemotherapy)
06/01/2006 - "OCT4 is superior to CD30 in the diagnosis of metastatic embryonal carcinomas after chemotherapy."
12/01/1989 - "Two patients who also had some areas of embryonal carcinoma in the resected specimens had post-operative chemotherapy and are alive disease free at 8 and 24 months respectively. "
06/01/1988 - "The authors conclude that survival of patients with embryonal carcinoma has greatly improved over the last decade as a result of improved methods for early detection of metastatic deposits and the effectiveness of newer chemotherapies in the treatment of disseminated disease."
03/01/2012 - "Surveillance was applied in 4 of these patients, and chemotherapy was used in the patient with embryonal carcinoma. "
06/01/2006 - "OCT4 is a useful diagnostic marker to identify metastatic embryonal carcinomas after chemotherapy, with a better sensitivity than CD30."
06/01/1985 - "Three patients with embryonal carcinoma responded well to combined surgical and chemo-radiotherapy. "
05/01/1985 - "Radiotherapy appears to have little role to play in the treatment of pure EST or embryonal carcinoma."
08/01/1981 - "Radiotherapy is not indicated in the treatment of infantile embryonal carcinoma."
02/01/1989 - "2. Of the embryonal carcinomas, the dysgerminomas are regularly cured by radiotherapy alone. "
06/01/2002 - "One patient developed pure seminoma 7 years after completion of radiotherapy, the other developed a combined tumour consisting of embryonal carcinoma and seminoma after 5 years. "
|3.||Combination Drug Therapy (Combination Chemotherapy)
06/01/1985 - "Successful treatment for children with embryonal carcinoma requires an operation aimed at either debulking or complete resection (if possible) coupled with early and aggressive combination chemotherapy. "
10/01/1992 - "A 32-year-old man who had left testicular embryonal carcinoma with low volume left para-aortic lymph node swelling was treated initially with 3 courses of cisplatin-based combination chemotherapy. "
07/01/1990 - "The types and cases are following: [table: see text] Multi-drug chemotherapy with cis-platinum has improved the prognosis of patients with embryonal carcinoma and yolk sac tumors, although patients with choriocarcinoma have yet a poor response to the combination chemotherapy. "
01/01/1999 - "Our preliminary results indicate that adjuvant therapy consisting of combination chemotherapy with cisplatin and etoposide and concomitant radiotherapy, followed by removal of the tumor, is highly effective in the treatment of pediatric patients with primary intracranial yolk sac tumor, embryonal carcinoma, or mixed germ cell tumors containing yolk sac tumor components."
01/01/1983 - "To characterize the toxic side-effects of bleomycin physiologically, pulmonary function, transcapillary escape rate of albumin, plasma volume and intravascular mass of albumin were determined prior to and during combination chemotherapy including cisplatin, vinblastine and bleomycin in 11 patients with stages I and II embryonal carcinoma of the testis. "
01/01/1998 - "In previous studies an increasing volume of embryonal carcinoma in the orchiectomy specimen was associated with a higher likelihood of being pathologic stage B. "
05/01/2014 - "High risk pathological features were found in the orchiectomy specimen in 12 patients (52.2%), including all 12 (52.2%) with 40% or greater embryonal carcinoma and 3 (13.0%) with lymphovascular invasion. "
01/01/2014 - "He underwent right orchidectomy and histology revealed an embryonal carcinoma with no vascular invasion. "
01/01/2012 - "All patients had predominantly embryonal carcinoma and/or lymphovascular invasion in their orchidectomy specimen. "
04/01/2010 - "Histology of the orchidectomy specimen consisted of embryonal carcinoma in 146 (76%) patients, also including lymphovascular invasion in 83 (44%). "
|5.||Lymph Node Excision (Lymph Node Dissection)
05/01/2009 - "Patients with greater than 30% embryonal carcinoma with or without lymphovascular invasion are at significant risk for metastatic disease and they can be successfully treated with primary retroperitoneal lymph node dissection. "
02/01/2012 - "Of the 91 patients who underwent extended template laparoscopic retroperitoneal lymph node dissection during the study period 60 (66%) had lymphovascular invasion and 55 (60%) had greater than 40% embryonal carcinoma. "
12/01/2011 - "On multivariate analysis embryonal carcinoma (OR 1.02, 95% CI 1.00-1.04) and lymphovascular invasion (OR 3.52, 95% CI 1.43-8.67) were associated with positive lymph nodes at retroperitoneal lymph node dissection. "
12/01/2011 - "Of 353 patients 90 (25%) had greater than 30% embryonal carcinoma and underwent primary retroperitoneal lymph node dissection. "
10/01/2003 - "We determined the pathological findings and clinical outcome of patients with pure embryonal carcinoma (EC) of the testis managed by primary retroperitoneal lymph node dissection. "