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Chondromatosis

Multiple formation of chondromas. (Dorland, 27th ed)

Also Known As:

Chondromatoses

Networked: 23 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2
  - Connective and Soft Tissue Neoplasms: 1
    - Connective Tissue Neoplasms: 9
      - Chondroma: 361
        Chondromatosis: 23
        Metachondromatosis: 8
        Dysplasia Epiphysealis Hemimelica with Chondromas and Osteochondromas
        Genochondromatosis

Related Diseases

1.	Osteoarthritis
2.	2-Hydroxyglutaricaciduria
3.	Neoplasms (Cancer)
4.	Neurodevelopmental Disorders
5.	Psoriatic Arthritis

Experts

1.	Kayamori, Kou: 1 article (07/2021)
2.	Sugiyama, Kentaro: 1 article (07/2021)
3.	Wake, So: 1 article (07/2021)
4.	Yoda, Tetsuya: 1 article (07/2021)
5.	Yoshitake, Hiroyuki: 1 article (07/2021)
6.	Prabhu, Sandeep: 1 article (08/2020)
7.	Scordino, Teresa: 1 article (08/2020)
8.	Shah, Rikin: 1 article (08/2020)
9.	Simon, Garfield: 1 article (08/2020)
10.	Sinha, Arpan A: 1 article (08/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chondromatosis:

1.	Amyloid (Amyloid Fibrils)IBA 09/01/1993 - "In certain cases, such as in amyloid and synovial osteo chondromatosis, however, MR imaging may be virtually diagnostic. " 01/01/1981 - "Pyrophosphate and capsular chondromatosis were demonstrated histologically in 15 cases, 14 of which also exhibited local deposition of amyloid. " 12/01/1983 - "Amyloid in osteoarthritic hip joints: deposits in relation to chondromatosis, pyrophosphate, and inflammatory cell infiltrate in the synovial membrane and fibrous capsule."
2.	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 08/01/2020 - "Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA) is a type of D-2-HGA that has been previously reported in ten patients (OMIM 614875), three of whom had somatic mosaicism for R132 variants in isocitrate dehydrogenase 1 (IDH1). " 10/01/2023 - "Germline pathogenic variants in isocitrate dehydrogenase 1 (IDH1) can lead to a rare neurodevelopmental disorder called metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria, including severe skeletal and cerebral anomalies. "
3.	Capsules (Microcapsules)IBA 01/01/1952 - "[Tumor like chondromatosis of the knee joint capsule with osseous transformations]." 12/01/1983 - "Amyloid in osteoarthritic hip joints: deposits in relation to chondromatosis, pyrophosphate, and inflammatory cell infiltrate in the synovial membrane and fibrous capsule."
4.	AcidsIBA 11/01/2011 - "Thus, somatic mutations in IDH1 may explain all features of MC-HGA, including sporadic occurrence, metaphyseal disorganization, and chondromatosis, urinary excretion of D-2-hydroxy-glutaric acid, and reduced cerebral myelinization." 11/01/2018 - "Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA) (OMIM 614875) is a severe chondrodysplasia combined with a urinary excretion of D-2-hydroxyglutaric acid. " 11/01/2011 - "We used exome sequencing of blood DNA in four unrelated patients to identify the genetic basis of metaphyseal chondromatosis with urinary excretion of D-2-hydroxy-glutaric acid (MC-HGA), a rare entity comprising severe chondrodysplasia, organic aciduria, and variable cerebral involvement. "
5.	diphosphoric acid (pyrophosphoric acid)IBA 01/01/1981 - "Pyrophosphate and capsular chondromatosis were demonstrated histologically in 15 cases, 14 of which also exhibited local deposition of amyloid. " 12/01/1983 - "Amyloid in osteoarthritic hip joints: deposits in relation to chondromatosis, pyrophosphate, and inflammatory cell infiltrate in the synovial membrane and fibrous capsule."
6.	Durapatite (Hydroxylapatite)IBA 10/01/1982 - "Incubation of minced, focally calcified, chondromatosis tissue obtained at operation from a patient with Milwaukee shoulder (rotator cuff defect and glenohumeral osteoarthritis associated with synovial fluid, hydroxyapatite crystals in microspheroidal masses, collagenase, and neutral protease) with partially purified mammalian synovial cell collagenase released masses of hydroxyapatite crystals of the same size as those originally found in the patient's synovial fluid. "
7.	Collagenases (Collagenase)FDA Link 10/01/1982 - "Incubation of minced, focally calcified, chondromatosis tissue obtained at operation from a patient with Milwaukee shoulder (rotator cuff defect and glenohumeral osteoarthritis associated with synovial fluid, hydroxyapatite crystals in microspheroidal masses, collagenase, and neutral protease) with partially purified mammalian synovial cell collagenase released masses of hydroxyapatite crystals of the same size as those originally found in the patient's synovial fluid. "
8.	Biomarkers (Surrogate Marker)IBA 07/01/2021 - "Biomarker expression related to chondromatosis in the temporomandibular joint."
9.	Uric Acid (Urate)IBA 09/01/2004 - "We report here a case of tenosynovial chondromatosis with deposits of crystalline material that appeared to be sodium urate (gouty tophi). "
10.	Proteins (Proteins, Gene)FDA Link 01/01/1973 - "[Metabolic disorders of protein-polysaccharide compounds and their role in the pathogenesis of joint chondromatosis]."

Therapies and Procedures

1.	Therapeutics 10/01/2004 - "[Recurrent chondromatosis of the metacarpophalangeal joint of the thumb -- differential diagnosis and therapy]." 02/01/2001 - "[Soft tissue chondromatosis of the foot: diagnosis and therapy]." 05/01/2008 - "The purpose of this study was to evaluate the treatment-specific outcome of surgical therapy of chondromatosis of the elbow with special attention on the complication and recurrence rate as well as induction of secondary osteoarthritis. "
2.	Oral Medicine 09/01/2016 - "The aim of our study was to analyse a series of patients suffering from temporomandibular joint (TMJ) chondromatosis treated in 2 departments of stomatology and maxillofacial surgery (University hospitals of the Conception in Marseille and of Caen) and to make a general review of this disease. "
3.	Oral Surgery (Maxillofacial Surgery) 09/01/2016 - "The aim of our study was to analyse a series of patients suffering from temporomandibular joint (TMJ) chondromatosis treated in 2 departments of stomatology and maxillofacial surgery (University hospitals of the Conception in Marseille and of Caen) and to make a general review of this disease. "
4.	Synovectomy 01/01/2020 - "With complete removal of the metaplastic tissue and synovectomy, the recurrence of the chondromatosis is not apparent yet until now. " 10/01/2014 - "The aim of the treatment is reduction of hip pain through arthroscopic synovectomy of the hip joint, reduction in activity of the synovial disease and removal of loose bodies in chondromatosis. " 01/01/1981 - "This incision has mainly been tested for subtotal elbow synovectomy in rheumatoid arthritis, for the mobilization of posttraumatic stiff elbows and the removal of loose bodies as in chondromatosis."
5.	Radiotherapy 12/01/2023 - "Particularly, we aspired to delve into the use of the MAKO in an orthopedic oncology setting for patients with a degenerative hip or knee and a history of cancer or other orthopedic tumor, impending pathological fracture, PVNS, chondromatosis, radiation therapy, or other oncological related conditions. "