|1.||Tuberous Sclerosis (Bourneville's Disease)
|5.||Astrocytoma (Pilocytic Astrocytoma)
|1.||Moss, Joel: 60 articles (11/2015 - 03/2002)|
|2.||McCormack, Francis X: 26 articles (09/2015 - 04/2003)|
|3.||Seyama, Kuniaki: 25 articles (12/2015 - 01/2002)|
|4.||Taveira-DaSilva, Angelo M: 23 articles (10/2015 - 12/2003)|
|5.||Krymskaya, Vera P: 20 articles (12/2015 - 08/2002)|
|6.||Pacheco-Rodriguez, Gustavo: 18 articles (04/2015 - 03/2002)|
|7.||Johnson, Simon R: 15 articles (12/2015 - 04/2002)|
|8.||Steagall, Wendy K: 15 articles (04/2015 - 12/2005)|
|9.||Moss, J: 14 articles (03/2011 - 02/2000)|
|10.||Young, Lisa R: 12 articles (08/2013 - 05/2006)|
|1.||Sirolimus (Rapamycin)FDA Link
08/01/2013 - "Efficacy of sirolimus therapy for chylous effusions in lymphangioleiomyomatosis."
08/01/2013 - "In the MILES trial, patients with lymphangioleiomyomatosis who had forced expiratory volume in 1 second (FEV1) of 70% or less of predicted were randomly assigned (1:1) to 12 months masked treatment with sirolimus or placebo. "
06/01/2013 - "Using data from the Multicenter International Lymphangioleiomyomatosis Efficacy and Safety of Sirolimus trial, we performed analyses to examine associations between SGRQ scores and values for four external measures (anchors). "
05/01/2006 - "Trials of rapamycin in lymphangioleiomyomatosis are currently underway and offer hope of evidence-based treatment for the disease."
11/01/2015 - "Intracrine steroid production and mammalian target of rapamycin pathways in pulmonary lymphangioleiomyomatosis."
10/25/2001 - "To study the clinical features, treatment, and prognosis of pulmonary lymphangioleiomyomatosis (LAM). "
12/01/2015 - "Lymphangioleiomyomatosis (LAM) is a rare multisystem disease. "
11/01/2015 - "Lymphangioleiomyomatosis (LAM) is a rare, potentially fatal disease primarily affecting young women. "
11/01/2015 - "Lymphangioleiomyomatosis (LAM) is a rare neoplastic metastatic disease affecting women of childbearing age. "
10/01/2015 - "Lymphangioleiomyomatosis (LAM) is a proliferation of perivascular epithelioid cells typically affecting the lung as a low-grade, destructive and progressive disease but may also be found in lymph nodes and other organs. "
|3.||Vascular Endothelial Growth Factor DIBA
11/01/2015 - "Correlation of serum vascular endothelial growth factor-D concentration with clinical presentation and course of lymphangioleiomyomatosis."
08/01/2013 - "Serum VEGF-D is a biologically plausible and useful biomarker in lymphangioleiomyomatosis that correlates with disease severity and treatment response. "
09/01/2010 - "Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases."
05/01/2009 - "Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement."
01/10/2008 - "Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis."
|4.||70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
02/01/2009 - "The pathogenesis of lymphangioleiomyomatosis is determined by mutations affecting tuberous sclerosis complex (TSC) genes, with eventual deregulation of the Rheb/mTOR/p70S6K pathway, and the potential therapeutic activity of mTOR inhibitors is currently under investigation. "
06/01/2006 - "This study was undertaken to determine whether the mTOR/p70 S6 kinase signaling pathway is activated in lymphangioleiomyomatosis-associated angiomyolipomas lacking TSC1/TSC2 loss of heterozygosity. "
06/01/2006 - "These data suggest that activation of the Rheb/mTOR/p70 S6 kinase pathway is related to the pathogenesis of lymphangioleiomyomatosis-associated and sporadic angiomyolipomas lacking TSC1/TSC2 loss of heterozygosity. "
06/01/2006 - "Moderate or strong phospho-ribosomal protein S6 immunoreactivity was found in all lymphangioleiomyomatosis-associated and sporadic angiomyolipomas, suggesting a high incidence of mTOR/p70 S6 kinase signaling pathway activation despite a lack of TSC1/TSC2 loss of heterozygosity. "
06/01/2006 - "TSC2 mutations and loss of heterozygosity have been identified in sporadic lymphangioleiomyomatosis-associated angiomyolipomas, thus implicating the TSC/Ras homolog-enriched in brain (Rheb)/mammalian target of Rapamycin (mTOR)/p70 S6 kinase signaling pathway in their pathogenesis. "
|5.||Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric
01/01/1995 - "[Pulmonary lymphangiomyomatosis: a 3-year follow-up of medroxyprogesterone acetate therapy. "
06/01/1990 - "Successful treatment of pulmonary lymphangioleiomyomatosis with oophorectomy and medroxyprogesterone-acetate: report of a case and brief review of the literature."
04/01/2005 - "We report a rare case ofpost-menopausal onset pulmonary lymphangioleiomyomatosis in a 62-year old Caucasian female that was diagnosed at age 53 and responded well to intramuscular injections of Depo-Provera and bilateral oophorectomy. "
01/01/1996 - "Pulmonary lymphangioleiomyomatosis: a case report in postmenopausal woman treated with pleurodesis and progesterone (medroxyprogesterone acetate)."
10/01/2003 - "[High efficacy of pleurodesis using OK-432 for controlling intractable pneumothorax associated with pulmonary lymphangioleiomyomatosis]."
10/01/2003 - "We evaluated the efficacy of pleurodesis using OK-432 (Picibanil) for the treatment of pneumothorax associated with pulmonary lymphangioleiomyomatosis (LAM). "
|8.||Ba 598 (flutropium bromide)IBA
09/01/2015 - " was a phase IIa, multicentre, open-label study of the mTOR inhibitor everolimus (2.5 mg·day(-1) escalated to 10 mg·day(-1)) in 24 women with lymphangioleiomyomatosis. "
09/01/2015 - "Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study."
07/22/2013 - "Everolimus treatment of abdominal lymphangioleiomyoma in five women with sporadic lymphangioleiomyomatosis."
03/01/2014 - "Re: everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial."
08/01/2013 - "Commentary on: everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial."
01/01/2015 - "A case of recurrent retroperitoneal lymphangioleiomyomatosis treated with progesterone therapy."
12/01/2004 - "Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone."
08/01/1999 - "Decline in lung function in lymphangioleiomyomatosis: relation to menopause and progesterone treatment."
11/01/1995 - "Response to treatment with progesterone in a patient with pulmonary lymphangioleiomyomatosis."
08/01/1991 - "Lymphangioleiomyomatosis--treatment with progesterone."
04/01/1995 - "A 41-year-old woman with pulmonary lymphangiomyomatosis had been scheduled for bilateral oophorectomy which led to amelioration of the pulmonary pathology. "
03/01/1995 - "[Subarachnoid block for ovariectomy in a patient with pulmonary lymphangioleiomyomatosis]."
03/01/1989 - "Anesthetic management for oophorectomy in a patient with lymphangiomyomatosis."
09/01/1987 - "Anaesthetic management for oophorectomy in pulmonary lymphangiomyomatosis."
01/01/1985 - "We report a patient with pulmonary lymphangioleiomyomatosis successfully treated by pleurectomy and oophorectomy."
10/19/2013 - "[Lung transplantation in sporadic lymphangioleiomyomatosis: study of 7 cases]."
10/01/2015 - "Mayo clinic experience of lung transplantation in pulmonary lymphangioleiomyomatosis."
07/01/2015 - "Lung Transplantation for Lymphangioleiomyomatosis in a Single Japanese Institute, With a Focus on Late-onset Complications."
04/01/2015 - "Genetic heterogeneity of circulating cells from patients with lymphangioleiomyomatosis with and without lung transplantation."
03/01/2015 - "This article presents the case report of a female patient with lymphangioleiomyomatosis who underwent single lung transplantation on the left side on 4. 10. "
04/01/2006 - "CT of pleural abnormalities in lymphangioleiomyomatosis and comparison of pleural findings after different types of pleurodesis."
04/01/2002 - "Lymphangioleiomyomatosis: correlation of qualitative and quantitative thin-section CT with pulmonary function tests and assessment of dependence on pleurodesis."
10/01/1999 - "In the other two patients, one with lymphangioleiomyomatosis and the other with nonchylous pleural fluid, continued effusion was successfully treated by means of pleurodesis. "
07/01/1987 - "Open lung biopsy confirmed the clinical impression of pulmonary lymphangiomyomatosis, and a pleurodesis was performed. "
04/01/1993 - "At right and left thoracotomy, lymphangiomyomatosis of the lung was found and treated by pleurodesis. "
01/10/2008 - "Some patients with lymphangioleiomyomatosis had improvement in spirometric measurements and gas trapping that persisted after treatment. "
05/01/2011 - "Evolution of pulmonary function after treatment with goserelin in patients with lymphangioleiomyomatosis."
12/01/2012 - "Reduction in size of renal angiomyolipoma after treatment with everolimus in lung transplantation due to lymphangioleiomyomatosis."