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Thrombin Receptors (Thrombin Receptor)

A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Also Known As:
Thrombin Receptor; Receptors, Thrombin; TRAP Peptide; Thrombin Receptor Activating Peptide Ligand; Thrombin Receptor Activating Peptides; Thrombin Receptor Activator Peptide; Peptide, TRAP; Receptor, Thrombin
Networked: 257 relevant articles (8 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Strony, John: 11 articles (06/2015 - 01/2012)
2. Harrington, Robert A: 11 articles (06/2015 - 01/2012)
3. Van de Werf, Frans: 11 articles (06/2015 - 11/2010)
4. Mahaffey, Kenneth W: 11 articles (06/2015 - 01/2012)
5. Tricoci, Pierluigi: 11 articles (06/2015 - 01/2012)
6. Aylward, Philip E: 10 articles (11/2015 - 01/2012)
7. White, Harvey D: 10 articles (06/2015 - 01/2012)
8. Armstrong, Paul W: 10 articles (06/2015 - 01/2012)
9. Moliterno, David J: 10 articles (05/2015 - 01/2012)
10. Chen, Edmond: 10 articles (05/2015 - 01/2012)

Related Diseases

1. Acute Coronary Syndrome
2. Hemorrhage
3. Thrombosis (Thrombus)
4. Neoplasm Metastasis (Metastasis)
5. Myocardial Infarction

Related Drugs and Biologics

1. Platelet Aggregation Inhibitors (Antiplatelet Drugs)
2. SCH 530348
3. Collagen
4. von Willebrand Factor
5. Purinergic P2Y Receptor Antagonists
6. prasugrel
7. nitroaspirin
8. Thrombin
9. PAR-1 Receptor
10. clopidogrel (Plavix)

Related Therapies and Procedures

1. Lasers (Laser)
2. Transplants (Transplant)
3. Coronary Artery Bypass (Coronary Artery Bypass Surgery)
4. Analgesia
5. Angioplasty (Angioplasty, Transluminal)