Flavivirus Infections

11/01/2007 - "Development of improved vaccines against Flavivirus infections is therefore important. "
01/01/2020 - "Flavivirus infections are a public health threat in the world that requires the development of safe and effective vaccines. "
10/01/2009 - "Development of safe and effective live-virus vaccines against neurotropic flavivirus infections demands a detailed knowledge of their neuropathogenesis in a primate host that is evolutionarily close to humans. "
12/01/2012 - "This information is invaluable for interpreting current investigations on the functional activities of polyclonal antibody responses to flavivirus infections and vaccinations and may open new avenues for studies on flavivirus cell biology and vaccine design."
01/01/2023 - "Vaccines prevent flavivirus infection. "

09/15/2011 - "In the absence of TRIM79α, IFN-β was less effective in inhibiting tick-borne flavivirus infection of mouse macrophages, highlighting the importance of a single virus-specific ISG in establishing an antiviral state. "
08/01/2004 - "Here we review models in mice and hamsters that may be used to assess the efficacy of novel antiviral strategies against flavivirus infections."
11/01/2016 - "Previous studies demonstrated that the mouse Oas1b gene conferred resistance to the flavivirus infection in mice; however, the antiviral activity of other mouse Oas1 gene family is still unknown. "
01/01/2023 - "These results unveil the potential of novel antiviral strategies based on the modulation of the cellular levels of dhSM and Des1 activity for the control of flavivirus infection."
11/01/2022 - "Currently, there are no clinically approved antiviral drugs for the treatment of flavivirus infections. "

12/01/2001 - "The different alleles of the murine Flv gene confer resistance or susceptibility to flavivirus-induced disease and provide a natural mutant system for the study of a host protein that can alter the outcome of a flavivirus infection. "
01/01/1994 - "We have used tick-borne encephalitis virus to study the involvement of acidic compartments during the entry and release phases of flavivirus infection and to elucidate the role of protein prM in immature virions. "
11/22/2023 - "Flavivirus infection induces the expression of a cellular protein RBM10, which interacts with JINR1. "
09/14/2023 - "Our findings indicate that exogenous flaviviral sNS1 proteins interfere with DC-mediated stimulation of T cells, which is crucial for the initiation of cell-mediated adaptive immune responses in human flavivirus infections. "
01/01/2023 - "Secretory pathways and multiple functions of nonstructural protein 1 in flavivirus infection."

01/01/2012 - "While cross-reactive antibodies with therapeutic potential against flaviviruses have been generated, the majority of them are anti-E antibodies with the potential to cause antibody-dependent enhancement of flavivirus infection and disease. "
08/01/2015 - "The study thus provided important new information on the potential immunomodulatory role of preexisting antibodies in a flavivirus system that can be relevant for understanding individual-specific factors influencing antibody responses in sequential flavivirus infections and/or immunizations."
01/10/2023 - "However, its use is limited due to the uncertainty caused by the cross-reaction of antibodies elicited in response to other flavivirus infections when tested in direct immunoassays. "
12/13/2022 - "These antibodies can be potentially applied to differential diagnosis of DENV from other flavivirus infections."
01/01/2021 - "Using this approach, we were able to define the unique in vivo dynamics of complex polyclonal antibodies, allowing for both enhancement and protection from flavivirus infection. "

02/17/2021 - "Although live attenuated vaccines (LAVs) have been effective in the control of flavivirus infections, to date they have been excluded from Zika virus (ZIKV) vaccine trials due to safety concerns. "
01/15/2002 - "Clinical proof of principle for ChimeriVax: recombinant live, attenuated vaccines against flavivirus infections."

02/01/2003 - "However, ribavirin did not enhance the inhibitory effect of interferon therapy in this animal model for flavivirus infections."
03/01/1990 - "The prophylactic efficacy of the broad-spectrum antiviral nucleoside analog ribavirin against flavivirus infection in non-human primates was investigated in a blinded, placebo-controlled study of rhesus monkeys infected with dengue virus. "

12/01/2009 - "Nevertheless, our results have proved the concept that a nucleoside inhibitor could be developed for potential treatment of flavivirus infections."
03/01/1990 - "The prophylactic efficacy of the broad-spectrum antiviral nucleoside analog ribavirin against flavivirus infection in non-human primates was investigated in a blinded, placebo-controlled study of rhesus monkeys infected with dengue virus. "

01/01/2018 - "In American Samoa and Puerto Rico, more than 80% of IgM-positive results were unspecified flavivirus infections. "
01/01/2020 - "Nevertheless, in endemic areas, where secondary flavivirus infections are common, diagnostic sensitivity of the NS1 and IgM test components may be compromised."
06/23/2017 - "Zika virus RT-PCR was positive on placental tissues from 38/363 (10%) live births with maternal serologic evidence of recent unspecified flavivirus infection and from 9/86 (10%) with negative maternal Zika virus immunoglobulin M (IgM) where possible maternal exposure occurred >12 weeks before serum collection. "
06/01/2003 - "Recent flavivirus infection was diagnosed for any individual with an IgM result > 40 units. "
04/01/2000 - "The Dot Blot IgM ELISA showed higher sensitivity than the PanBio IgM ELISA (100 vs. 95%), while the PanBio IgM ELISA showed higher specificity in JE (100 vs. 20%) and non-flavivirus infections (100 vs. 97%). "

11/27/2023 - "RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection."
09/06/2023 - "Using qCARMEN, we studied the response profiles of interferon-stimulated genes (ISGs) during interferon (IFN) stimulation and flavivirus infection. "
05/22/2023 - "RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection."
12/07/2022 - "Myeloid cell interferon secretion restricts Zika flavivirus infection of developing and malignant human neural progenitor cells."
01/01/2022 - "Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection."

02/01/2021 - "Pathogenic as well as protective effects of complement have been reported in flavivirus infections. "
06/09/2021 - "Historically, NS1 has been used as a diagnostic marker for the flavivirus infection due to its complement fixing properties and specificity. "
02/01/2021 - "Role of the complement system in antibody-dependent enhancement of flavivirus infections."
01/01/2019 - "The complement system is a part of the innate immune response in the CNS, which previously has been reported to be activated in other flavivirus infections. "
01/01/2017 - "The complement system has been described to play an important role in flavivirus infection either by protecting the host and/or by influencing disease pathogenesis. "

10/01/2021 - "Therefore, our studies have significances both for understanding of the full scope of mechanisms of TMUV and other flavivirus infection, and conceivably, for therapeutics."
11/15/2019 - "Our study reveals the escape of TMUV from the first line of the host defense system in the arthropod-borne transmission route of arboviruses, possibly helping to extend our understanding of flavivirus infection in birds and refine the design of anti-TMUV therapeutics."
01/01/2006 - "Mouse and hamster models for the study of therapy against flavivirus infections."
08/01/2004 - "Rodent models for the study of therapy against flavivirus infections."
01/05/2001 - "A novel model for the study of the therapy of flavivirus infections using the Modoc virus."

01/01/2019 - "A high-throughput and multiplex microsphere immunoassay based on non-structural protein 1 can discriminate three flavivirus infections."
12/01/2018 - "We developed and validated a multiplexed flavivirus immunoglobulin M (IgM) microsphere immunoassay (flaviMIA) which can differentiate ZIKV-specific IgM from that due to other flavivirus infections in humans. "
01/01/2015 - "The microspheres coupled to WNV.sE or rEDIIIs were assayed with about 300 equine immune sera from natural and experimental flavivirus infections and 172 nonimmune equine sera as negative controls. "

11/02/2016 - "Retraction note: Neuropathological microscopic features of abortions induced by Bunyavirus/or Flavivirus infections."
11/26/2014 - "Neuropathological microscopic features of abortions induced by Bunyavirus / or Flavivirus infections."

09/30/2020 - "The aims of the IPD-MA are to (1) estimate the absolute and relative risks of miscarriage, fetal loss, and short- and long-term sequelae of fetal exposure; (2) identify and quantify the relative importance of different sources of heterogeneity (e.g., immune profiles, concurrent flavivirus infection) for the risk of adverse fetal, infant, and child outcomes among infants exposed to ZIKV in utero; and (3) develop and validate a prognostic model for the early identification of high-risk pregnancies and inform communication between health care providers and their patients and public health interventions (e.g., vector control strategies, antenatal care, and family planning programs). "

01/01/2023 - "ER stress and ecto-CRT are hallmarks of chemotherapy-induced immunogenic cell death5,6, flavivirus infection and senescence. "