Agrin

A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.

Networked: 216 relevant articles (4 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mei, Lin: 13 articles (01/2021 - 10/2008)
2.	Kröger, Stephan: 7 articles (01/2021 - 07/2002)
3.	Kovalszky, Ilona: 7 articles (01/2016 - 01/2004)
4.	Tátrai, Péter: 7 articles (01/2016 - 01/2004)
5.	Chakraborty, Sayan: 6 articles (11/2021 - 01/2015)
6.	Hong, Wanjin: 6 articles (11/2021 - 01/2015)
7.	Xiong, Wen-Cheng: 6 articles (01/2019 - 04/2012)
8.	Hettwer, Stefan: 6 articles (01/2018 - 11/2007)
9.	Lin, Shuo: 6 articles (11/2014 - 07/2007)
10.	Schaff, Zsuzsa: 6 articles (09/2010 - 01/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Targeting the endothelial derived agrin might not be effective in inhibiting tumor angiogenesis." 11/01/2006 - "Given the selectivity of agrin for tumor microvessels, agrin immunohistochemistry may prove helpful in recognizing malignant transformation in cirrhotic livers. " 01/01/2021 - "This study examined the effects and the underlying mechanisms of Agrin in NSCLC and tumor-infiltrated immune cells. " 12/01/2008 - "By double immunofluorescent studies, agrin was localized to the muscular layer of blood vessel walls, the BM of bile ducts and ductular reaction, the microvessel walls of HCC, and occasionally the BM of hepatocellular tumor cells. " 05/01/2021 - "Furthermore, agrin-depleted CCA cells developed fewer and smaller tumors than control cells in vivo. "
2.	Myasthenia Gravis 01/01/2020 - "Our aim in this study was to identify the prevalence and clinical characteristics of LRP4/agrin-antibody-positive double-seronegative myasthenia gravis (DNMG). " 01/01/2020 - "Clinical features of LRP4/agrin-antibody-positive myasthenia gravis: A multicenter study." 10/01/2015 - "Agrin-associated myasthenia gravis might emerge as a new entity. " 01/01/2012 - "As lack of ColQ compromises agrin-mediated AChR clustering in Colq-/- mice, a similar mechanism may lead to AChR deficiency in MuSK-MG patients." 11/15/2011 - "As lack of ColQ compromises agrin-mediated AChR clustering in Colq-/- mice, a similar mechanism may lead to AChR deficiency in MuSK-MG patients. "
3.	Fibrosis (Cirrhosis) 12/01/2008 - "In both human and rats, significantly increased expression of agrin in cirrhosis and HCC was demonstrated by immunohistochemistry (IHC), Western blot, and quantitative RT-PCR. " 11/01/2006 - "Vascular and peribiliary basement membranes were strongly immunopositive for agrin in 29/29 human liver specimens with cirrhosis and HCC. " 01/01/2020 - "A single dose of recombinant human agrin improved heart function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. " 01/01/2018 - "Because agrin can induce only mild cardiomyocyte proliferation compared with ERBB2 pathway activation, it might exert pleiotropic effects, such as mitigation of innate inflammation, immune response, and fibrosis. " 11/01/2006 - "Agrin, a novel basement membrane component in human and rat liver, accumulates in cirrhosis and hepatocellular carcinoma."
4.	Infarction (Infarctions) 01/01/2020 - "A single dose of recombinant human agrin improved heart function, infarct size, fibrosis, and adverse remodeling parameters 28 days after MI. "
5.	Autoimmune Diseases (Autoimmune Disease) 12/01/2007 - "It is shown in this study that the heparan sulfate proteoglycan agrin is overexpressed in T cells isolated from patients with the autoimmune disease systemic lupus erythematosus (SLE). " 06/01/2017 - "Our aims were to study the frequency of antibodies against lipoprotein-related protein 4 (LRP4), agrin, and titin using the most recent techniques, and to characterize corresponding clinical features and autoimmune diseases (AID) in 100 MG-patients. " 01/01/2021 - "Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. " 10/01/2015 - "Myasthenia gravis is an autoimmune disease that is characterised by muscle weakness and fatigue, is B-cell mediated, and is associated with antibodies directed against the acetylcholine receptor, muscle-specific kinase (MUSK), lipoprotein-related protein 4 (LRP4), or agrin in the postsynaptic membrane at the neuromuscular junction. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antibodies
3.	perlecan
4.	Proteoglycans (Proteoglycan)
5.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
6.	Messenger RNA (mRNA)
7.	Protein Isoforms (Isoforms)
8.	Lipoproteins (Lipoprotein)
9.	Laminin (Merosin)
10.	Dystroglycans (Dystroglycan)

Related Therapies and Procedures

1.	Spinal Injections
2.	Therapeutics
3.	Electroacupuncture
4.	Transplantation
5.	Plasma Exchange