|1.||Trauner, Michael: 18 articles (09/2014 - 05/2004)|
|2.||Evans, Ronald M: 10 articles (05/2014 - 05/2004)|
|3.||Staels, Bart: 9 articles (10/2014 - 12/2004)|
|4.||Zollner, Gernot: 9 articles (08/2011 - 11/2005)|
|5.||Wagner, Martin: 7 articles (08/2011 - 11/2005)|
|6.||Glass, Christopher K: 7 articles (03/2011 - 01/2006)|
|7.||Grunfeld, Carl: 7 articles (10/2009 - 03/2003)|
|8.||O'Malley, Bert W: 6 articles (07/2014 - 02/2005)|
|9.||Tontonoz, Peter: 6 articles (03/2013 - 01/2004)|
|10.||Levi, Moshe: 6 articles (01/2013 - 10/2007)|
05/01/2009 - "For example, agents targeting nuclear receptors over-expressed in tumors can hone in on malignant tissue and result in improved chemotherapeutic treatments. "
06/15/2015 - "Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer. "
01/01/2009 - "Our earlier studies have shown that MLT exerts the inhibitory effect on murine cancer via membrane and nuclear receptors. "
01/01/2009 - "This review will summarize their mode of action, prognostic/therapeutic relevance, as well as preclinical and clinical studies currently targeting nuclear receptors in this tumor entity."
12/01/2015 - "Many members of the nuclear receptors (NRs) superfamily of transcriptional factors have key roles in cancer. "
|2.||Liver Diseases (Liver Disease)
10/15/2009 - "To review the new insights brought by the study of nuclear receptors to our understanding of the molecular basis of various liver diseases, and to summarize some of the recent studies that evaluated the efficacy of targeting nuclear receptor as a new approach in treating liver diseases. "
08/01/2015 - "Nuclear receptors (NRs) are critically involved in the regulation of these hepatic transporters and are natural targets for therapy of cholestatic liver diseases. "
07/14/2014 - "The expression of CYP enzyme genes and corresponding nuclear receptors was generally decreased in end-stage liver diseases, and significant differences in gene expression were evident between peri-HCC and HCC."
05/01/2013 - "Nuclear receptors as drug targets in cholestatic liver diseases."
05/01/2011 - "This review will provide an overview of the role of nuclear receptors in bile acid homeostasis with a focus on the farnesoid X receptor (FXR) and its potential therapeutic use in cholestatic liver diseases. "
07/28/2009 - "Drugs targeting, for example, receptors of viral entry, host metabolism or nuclear receptors, which are factors required to complete the HCV life cycle, may be more effective in combating the viral infection. "
04/12/2013 - "Nuclear receptors modulate macrophage effector functions, which are imperative for clearance or survival of mycobacterial infection. "
11/01/2012 - "They are both cytoplasmic receptors, and sense microbial infections/danger molecules to induce host innate immune response. "
03/01/2012 - "Therefore, FXR and SHP appear to play a limited role in modulating HBV biosynthesis, suggesting that alternative nuclear receptors are more critical determinants of viral transcription in the HBV transgenic mouse model of chronic viral infection. "
10/12/2011 - "I will review the mechanisms of pathogen recognition by TLRs and cytoplasmic receptors, and then discuss the roles of these receptors in the development of adaptive immunity in response to viral infection."
|4.||Prostatic Neoplasms (Prostate Cancer)
08/01/2012 - "Recent studies have underlined the role of nuclear receptors in the involvement of prostate cancer signalling pathways. "
08/01/2013 - "The changing roles of steroid nuclear receptors with prostate cancer progression."
12/01/2012 - "DC-SCRIPT is a key regulator of nuclear receptors AR and VDR that play an opposite role in prostate cancer etiology and loss of DC-SCRIPT may be involved in the onset of prostate cancer."
03/01/2012 - "Nuclear receptors and pioneer factors drive the development and progression of prostate cancer. "
05/06/2010 - "Therefore, we investigated whether these nuclear receptors could modulate lipid raft signaling and consequently alter prostate cancer (PCa) cell survival. "
01/01/2015 - "Nuclear receptors in acute and chronic cholestasis."
01/01/2015 - "Hepatic nuclear receptors, VDR, HNF4α, RXRα and RARα, were induced (approximately 2.0-fold, (p<0.05) whereas FXR levels were markedly reduced to 44% of control, (p<0.05) in human obstructive cholestasis. "
06/01/2014 - "In this article, we review the potential clinical implications of the major BS transporters BSEP, OSTα/OSTβ and NTCP in the pathogenesis of hereditary and acquired cholestatic syndromes, provide an overview on transcriptional control of these transporters by the key regulatory nuclear receptors and discuss the potential therapeutic role of novel transcriptional activators of BS transporters in cholestasis. "
05/01/2012 - "Nuclear receptors are key mediators of adaptive response mechanisms in cholestasis and potential therapeutical targets. "
06/01/2011 - "Nuclear receptors (NRs) are essential for regulating Mrp4 expression in cholestasis models. "
|2.||Transcription Factors (Transcription Factor)
|6.||Retinoid X Receptors (Retinoid X Receptor)
|8.||Steroid Receptors (Steroid Receptor)
|4.||Drug Therapy (Chemotherapy)