|1.||Flavell, Richard A: 12 articles (12/2013 - 11/2003)|
|2.||Gershwin, M Eric: 9 articles (10/2012 - 08/2006)|
|3.||Moses, Harold L: 8 articles (11/2014 - 10/2003)|
|4.||Lian, Zhe-Xiong: 8 articles (10/2012 - 08/2006)|
|5.||Blobe, Gerard C: 8 articles (08/2010 - 12/2002)|
|6.||Ansari, Aftab A: 7 articles (10/2012 - 08/2006)|
|7.||Coppel, Ross L: 7 articles (10/2012 - 08/2006)|
|8.||Ridgway, William M: 7 articles (10/2012 - 08/2006)|
|9.||Yang, Guo-Xiang: 6 articles (10/2012 - 02/2008)|
|10.||Tsuneyama, Koichi: 6 articles (10/2012 - 06/2008)|
03/01/2008 - "TGFBR1*6A is a common hypomorphic variant of the type 1 transforming growth factor beta receptor (TGFBR1), which has been associated with increased cancer risk in some studies. "
12/01/2002 - "Recent studies, however, have suggested that microsatellite unstable cancers with mutations in the proapoptotic gene BAX have a relatively poor prognosis, whereas those with mutations in transforming growth factor-beta receptor type II (TGFBRII) have a relatively good prognosis. "
03/01/2000 - "Numerous studies have now demonstrated that the TGF-beta receptor complex and its downstream signaling intermediates constitute a tumor suppressor pathway. "
01/20/2015 - "Smad4 deletion rescued the lethal autoimmunity resulting from transforming growth factor-beta receptor (TGF-βR) deletion and compromised T-cell-mediated tumor rejection. "
01/01/2015 - "Numerous epidemiological studies have evaluated the association between transforming growth factor beta receptor type 1 (TGFBR1) polymorphisms and the risk of cancer; however, the results remain inconclusive and controversial. "
04/01/2009 - "Small-molecule inhibitors of TGF-beta-receptor activity are effective in animal models of fibrosis. "
11/01/1995 - "Our study suggests that TGF-beta receptors I and II are important for the initial step of fibrosis."
08/01/2010 - "TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis."
04/08/2010 - "To examine the in vivo anti-fibrotic effect of rat soluble transforming growth factor beta receptor II (RsTbetaRII) and IFN-gamma fusion protein (RsTbRII-IFN-gamma) in rat hepatic fibrosis model. "
04/08/2010 - "Enhanced effect of soluble transforming growth factor-beta receptor II and IFN-gamma fusion protein in reversing hepatic fibrosis."
|3.||Neoplasm Metastasis (Metastasis)
01/01/2012 - "Immunohistochemical analysis of TGF-beta receptor type 2 and phosphorylated SMAD2 indicated that both were upregulated in omental metastases as compared to primary disease sites. "
01/01/2007 - "Decrease of both TGF-beta receptors in tumour-associated stroma was associated with increased lymph node metastasis and shorter survival. "
03/20/2003 - "We demonstrate that reduced expression of TGF-beta receptors in esophageal SCC appears to be correlated with depth of invasion, lymph node metastasis, pathologic stage and poor prognosis. "
02/15/2010 - "Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells."
09/01/2010 - "Reduced transforming growth factor-beta receptor II expression in hepatocellular carcinoma correlates with intrahepatic metastasis."
01/01/2012 - "Fluorescently labeled murine mammary carcinoma cells, isolated from either MMTV-PyVmT transforming growth factor-beta receptor II knockout (TβRII KO) or TβRIIfl/fl control mice, were combined with mammary fibroblasts and xenografted onto the chicken embryo chorioallantoic membrane. "
08/01/2004 - "Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1."
12/01/2003 - "Bcl-2 and TGF-beta receptors type II (RII) in colon carcinomas were studied in a series of 113 patients, to determine their prognostic significance and to correlate their expression with other prognostic indicators. "
06/15/2001 - "Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas."
09/21/2000 - "In this report, we describe the mechanism of TGF-beta receptor type I (RI) repression in the GEO human colon carcinoma cells. "
|5.||Colonic Neoplasms (Colon Cancer)
01/01/2012 - "MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells."
07/15/2004 - "Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer."
04/01/2002 - "Downregulation of TGF-beta receptors is implicated in colon cancer development. "
01/12/2001 - "Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III."
01/15/1999 - "Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers."
|1.||Transforming Growth Factor beta (TGF-beta)
|3.||Transforming Growth Factor beta1 (TGF beta 1)
|5.||Transforming Growth Factor beta2
|6.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|7.||RNA (Ribonucleic Acid)
|9.||Connective Tissue Growth Factor
|10.||Transforming Growth Factors (Transforming Growth Factor)
|2.||Transplantation (Transplant Recipients)
|4.||Heterologous Transplantation (Xenotransplantation)