B7-1 Antigen

A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.

Also Known As:

Networked: 64 relevant articles (3 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, J: 2 articles (10/2000 - 03/2000)
2.	Djamali, Arjang: 1 article (09/2015)
3.	Huang, Gengwen: 1 article (09/2015)
4.	Redfield, Robert R: 1 article (09/2015)
5.	Reese, Shannon R: 1 article (09/2015)
6.	Wilson, Nancy A: 1 article (09/2015)
7.	Zhong, Weixiong: 1 article (09/2015)
8.	Altintas, Mehmet M: 1 article (07/2014)
9.	Bassi, Roberto: 1 article (07/2014)
10.	Ben Nasr, Moufida: 1 article (07/2014)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2007 - "Transfection of the costimulatory molecule B7-1 gene into certain murine tumors increases antitumor immunity and suppresses tumor growth. " 02/01/2001 - "Expression of CD28 (the stimulatory B7.1 ligand) was significantly increased in both CD8(+) T cells and natural killer cell populations of mice rejecting tumor challenge compared to mice with tumor growth. " 03/01/2000 - "Recently, many experiments have shown that the expression of the costimulatory molecule B7-1 on tumor cells can induce tumor-specific immunity. " 12/01/1999 - "To explore the expression of B7-1 antigen (Ag), the most important costimulatory molecule for T-lymphocyte activation, on tumor cells from cancerous human tissues. " 12/01/1999 - "B7-1 antigen expression in tumor cells from cancerous human tissues."
2.	Breast Neoplasms (Breast Cancer) 05/07/2013 - "In this study, we have evaluated the efficacy of 4TO7, a highly tumorigenic murine mammary tumor cell line, expressing glycosyl phosphatidylinositol (GPI)-anchored form of cytokine molecules alone or in combination with the costimulatory molecule B7-1 as a model for potential cell or membrane-based breast cancer vaccines. "
3.	Residual Neoplasm 02/01/1996 - "In this work, using a murine model of acute myeloid leukemia, we demonstrate that the B7-1 costimulatory molecule is superior to the B7-2 molecule in its capacity to protect against wild-type tumor challenge and eradicate minimal residual disease. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/01/1996 - "In this work, using a murine model of acute myeloid leukemia, we demonstrate that the B7-1 costimulatory molecule is superior to the B7-2 molecule in its capacity to protect against wild-type tumor challenge and eradicate minimal residual disease. "
5.	Melanoma (Melanoma, Malignant) 05/01/1996 - "Key words: Melanoma; T cells; B7-1 costimulatory molecule (CD80); major histocompatibility complex." 05/01/1996 - "These melanoma cells had no detectable baseline surface expression of the B7-1 costimulatory molecule, but 8% to 31% of these cells became B7-1 positive with no selection procedure after gene transfer with human B7-1 cDNA. " 05/01/1996 - "Dual expression of human leukocyte antigen molecules and the B7-1 costimulatory molecule (CD80) on human melanoma cells after particle-mediated gene transfer." 05/01/1996 - "The aim of this study was to determine if human melanoma cells could be molecularly modified by particle-mediated gene transfer with a "gene gun", using genes for interferon-gamma (IFN-gamma), the B7-1 costimulatory molecule (CD80), and human leukocyte antigen (HLA)-A2, to augment expression of both HLA molecules and B7-1. " 08/01/1996 - "The results showed that IL-12 in combination with IL-2 enhanced the autologous anti-melanoma CTL response, whereas B7.1 antigen expression on tumour cells did not increase anti-melanoma CTL generation. "

Related Drugs and Biologics

1.	Cytokines
2.	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)
3.	Vaccines
4.	Prodrugs
5.	Glucuronidase
6.	9-aminocamptothecin
7.	aniline (aniline hydrobromide)
8.	Interleukin-12 (IL 12)
9.	Interferon-gamma (Interferon, gamma)
10.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy