A costimulatory ligand membrane glycoprotein that contains a V2 type and C2 IMMUNOGLOBULIN DOMAIN and is expressed by ANTIGEN-PRESENTING CELLS. It binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Also Known As:
Antigen, B7-1; B7-1 Ligand; CD80 Antigen; Antigen, B7 1; B Cell Activation Antigen; B7 1 Antigen; B7 1 Costimulatory Molecule; B7 1 Ligand; Costimulatory Molecule, B7-1; Ligand, B7-1; Antigens, CD80; B-Cell Activation Antigen; B7-1 Costimulatory Molecule; CD80 Antigens