Lipoprotein Receptors (Lipoprotein Receptor)

Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
Also Known As:
Lipoprotein Receptor; Receptors, Lipoprotein; Receptors, Lipoproteins; Lipoproteins Receptors; Receptor, Lipoprotein
Networked: 157 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Krieger, Monty: 5 articles (08/2012 - 06/2003)
2. Yesilaltay, Ayce: 4 articles (08/2012 - 04/2005)
3. Herz, Joachim: 3 articles (12/2014 - 11/2010)
4. Kocher, Olivier: 3 articles (08/2012 - 04/2005)
5. Murao, Koji: 2 articles (10/2015 - 02/2004)
6. Imachi, Hitomi: 2 articles (10/2015 - 02/2004)
7. Zheng, Gang: 2 articles (05/2015 - 12/2005)
8. Chen, Juan: 2 articles (05/2015 - 12/2005)
9. Bock, Hans H: 2 articles (12/2014 - 10/2006)
10. Fleming, Jodie M: 2 articles (01/2014 - 01/2014)

Related Diseases

1. Dyslipidemias (Dyslipidemia)
2. Hyperlipidemias (Hyperlipidemia)
3. Myocardial Infarction
08/01/2002 - "Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction."
06/01/2012 - "Our aims were to analyse the effect of hypoxia on low-density lipoprotein receptor-related protein 1 (LRP1) expression in neonatal rat ventricular myocytes (NRVM) and cardiac-derived HL-1 cells and the molecular mechanisms involved in this effect, to determine the role of LRP1 in the very low density lipoprotein (VLDL) uptake by hypoxic cardiomyocytes, and to study the effect of hypoxia on lipoprotein receptor expression and myocardial lipid profile in an in vivo porcine experimental model of acute myocardial infarction. "
11/01/2014 - "Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA) atherosclerosis, myocardial infarction, and early death. "
08/06/2013 - "Mice lacking both the high-density lipoprotein receptor SR-BI (scavenger receptor class B type I) and ApoE (apolipoprotein E), which promotes clearance of remnant lipoproteins, are a model of severe dyslipidemia and spontaneous myocardial infarction. "
06/10/2003 - "Mice with homozygous null mutations in the high-density lipoprotein receptor SR-BI (scavenger receptor class B, type I) and apolipoprotein E genes fed a low-fat diet exhibit a constellation of pathologies shared with human atherosclerotic coronary heart disease (CHD): hypercholesterolemia, occlusive coronary atherosclerosis, myocardial infarctions, cardiac dysfunction (heart enlargement, reduced systolic function and ejection fraction, and ECG abnormalities), and premature death (mean age 6 weeks). "
4. Hyperlipoproteinemias
5. Proteinuria

Related Drugs and Biologics

1. Lipoproteins (Lipoprotein)
2. Scavenger Receptors (Scavenger Receptor)
3. Apolipoproteins
4. Apolipoproteins E (ApoE)
5. Phosphatidylcholine-Sterol O-Acyltransferase (Lecithin Cholesterol Acyltransferase)
6. Sterol O-Acyltransferase
7. Acyl Coenzyme A (Acyl CoA)
8. Cholesterol
9. Apolipoprotein A-I (Apolipoprotein A1)
10. Amyloid beta-Peptides

Related Therapies and Procedures

1. Fat-Restricted Diet (Diet, Fat Restricted)
2. Thrombolytic Therapy