Histamine H3 Receptors (Histamine H3 Receptor)

A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H3 receptors were first recognized as inhibitory autoreceptors on histamine-containing nerve terminals and have since been shown to regulate the release of several neurotransmitters in the central and peripheral nervous systems. (From Biochem Soc Trans 1992 Feb;20(1):122-5)

Also Known As:

Networked: 315 relevant articles (23 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kieć-Kononowicz, Katarzyna: 21 articles (06/2022 - 09/2013)
2.	Sadek, Bassem: 19 articles (02/2021 - 07/2013)
3.	Stark, Holger: 15 articles (12/2021 - 07/2013)
4.	Łażewska, Dorota: 14 articles (01/2021 - 01/2016)
5.	Panula, Pertti: 8 articles (01/2021 - 01/2006)
6.	Chen, Zhong: 7 articles (11/2022 - 11/2004)
7.	Hancock, Arthur A: 7 articles (04/2005 - 06/2003)
8.	Szczepańska, Katarzyna: 6 articles (06/2022 - 01/2018)
9.	Eissa, Nermin: 6 articles (02/2021 - 01/2018)
10.	Alachkar, Alaa: 6 articles (01/2021 - 01/2017)

Related Diseases

1.	Narcolepsy 08/01/2017 - "H3 receptor antagonists represent a new therapeutic option for EDS in narcolepsy. " 01/01/2015 - "Some compounds, such as histaminergic H3 receptor antagonists, may prove useful in symptom control of narcolepsy. " 01/01/2022 - "The histamine H3 receptor has emerged as one of the most promising targets of novel pharmacotherapy for narcolepsy. " 05/15/2019 - "Pitolisant, a selective inverse agonist for the histamine H3 receptor, is a new treatment for adults suffering from narcolepsy. " 11/01/2013 - "We assessed the safety and efficacy of pitolisant (previously called BF2.649), a selective histamine H3 receptor inverse agonist that activates these neurons, in patients with narcolepsy. "
2.	Obesity 11/01/2007 - "In this review, we describe the implication and patent for developing H3 receptor antagonists and their therapeutic potential of obesity." 11/01/2007 - "Therapeutic approach of histamine H3 receptors in obesity." 04/01/2006 - "Herein, we describe the biological and chemical implications for developing H3 receptor antagonists and their therapeutic potential as disclosed through animal models of cognition, sleep, and obesity." 03/01/2005 - "Assessment of pharmacology and potential anti-obesity properties of H3 receptor antagonists/inverse agonists." 01/01/2016 - "The potential role of the H3 receptor as a target of anti-obesity therapeutics was explored in clinical trials that did not meet up to the expectations or were interrupted (clinicaltrials.gov). "
3.	Weight Gain 06/24/2022 - "Many studies involving compounds that enhance histamine release, such as histamine H3 receptor (H3R) antagonists, have shown efficacy in inhibiting weight gain, but none have passed clinical trials. " 04/19/2023 - "Many studies have shown the high efficacy of histamine H3 receptor ligands in preventing weight gain. " 02/01/2010 - "The present paper explores the potential candidature of histaminergic neurotransmission in the mechanisms of atypical antipsychotic-induced weight gain, with a focus on the histaminergic H1 and H3 receptors. " 02/01/2010 - "The role of histaminergic H1 and H3 receptors in food intake: a mechanism for atypical antipsychotic-induced weight gain?" 04/01/2016 - "The effects and mechanisms of betahistine (a histaminergic H1R agonist and H3 receptor antagonist) have been investigated for ameliorating SGA-induced weight gain/obesity in both animal models and clinical trials. "
4.	Cognitive Dysfunction 07/01/2008 - "The discovery of effective H3 antagonists as therapeutic agents for the novel treatment of cognitive disorders will only be accomplished through continued research efforts that further our insights into the functions of the H3 receptor." 07/01/2008 - "However, although a number of clinical studies examining the efficacy of H3 receptor antagonists for a variety of cognitive disorders are currently underway, no clinical proof of concept for an H3 receptor antagonist has been reported to date. " 01/01/2023 - "Histamine H3 receptor (H3R) antagonists reportedly have potential applications for treating cognitive impairment accompanied by various neuropsychiatric disorders. " 08/01/2022 - "Histamine H3 receptor (H3R) antagonists are considered as therapeutic factors for treating cognitive impairments. " 06/01/2021 - "Blockade of the presynaptic H3 receptors activates the downstream pathway(s) involved in the processes of learning and memory, making it a potential therapeutic option for ameliorating cognitive dysfunction. "
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/2019 - "In studies on the treatment of Alzheimer's disease (AD), in which cognition is enhanced even modestly or selectively, it has been considered that the histamine H3 receptor (H3R) may be a potential target. " 01/01/2017 - "The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established. " 02/01/2011 - "In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease." 08/12/2023 - "The role of histamine H3 receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer's disease (AD), is well-accepted. " 01/01/2018 - "The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. "

Related Drugs and Biologics

1.	pitolisant
2.	Ligands
3.	thioperamide
4.	Betahistine (Serc)
5.	Olanzapine (Zyprexa)
6.	Histamine H1 Receptors (Histamine H1 Receptor)
7.	Histamine (Histamine Dihydrochloride)
8.	Formaldehyde (Formol)
9.	Dopamine (Intropin)
10.	4-(1H-imidazol-4-ylmethyl)piperidine

Related Therapies and Procedures

1.	Therapeutics
2.	Continuous Positive Airway Pressure
3.	Subcutaneous Injections
4.	Injections
5.	Drug Therapy (Chemotherapy)