|1.||Devarajan, Prasad: 35 articles (01/2015 - 12/2004)|
|2.||Buemi, Michele: 18 articles (01/2015 - 01/2007)|
|3.||Mobashery, Shahriar: 15 articles (12/2015 - 03/2002)|
|4.||Chang, Mayland: 14 articles (12/2015 - 05/2005)|
|5.||Ronco, Claudio: 14 articles (07/2015 - 01/2008)|
|6.||Ma, Qing: 14 articles (03/2015 - 12/2004)|
|7.||Barasch, Jonathan: 14 articles (02/2015 - 12/2004)|
|8.||Yang, Shun-Fa: 14 articles (06/2014 - 06/2003)|
|9.||Bellomo, Rinaldo: 13 articles (12/2015 - 12/2007)|
|10.||Lacquaniti, Antonio: 12 articles (12/2013 - 01/2008)|
07/10/2015 - "In conclusion, the results of this study clearly demonstrated that the gelatinases-stimuli NPs are an efficient means to simultaneously deliver epigenetic and chemotherapeutic drugs that may effectively inhibit cancer cell proliferation. "
06/01/2010 - "AA treatment results in a decrease in gelatinase activity that correlates with the significant decrease in tumor burden shown by the authors' previous studies. "
10/15/2008 - "In addition, we also detected several unidentified urinary gelatinase activities with molecular weights >125 kDa. The objective of the current study was to identify these high molecular weight (HMW) species, determine their potential as predictors of disease status, and ask whether a tumor-specific pattern existed based on urinary MMP analysis. "
02/01/2006 - "Tumor gelatinase targeting was evaluated in both biodistribution and microPET imaging studies. "
03/01/2005 - "In this review, the impact of the gelatinases and their inhibitors on the clinical course in several solid cancers is evaluated based on the growing data from recent clinical studies. "
|2.||Acute Kidney Injury (Acute Renal Failure)
03/01/2005 - "Our data suggest that stimulation of gelatinase activity during ischemia could contribute to glomeruli injury, providing new therapeutic targets for acute renal failure in humans. "
01/01/2016 - "In our adjusted models, enrollment neutrophil gelatinase-associated lipocalin level was independently associated with survival even after controlling for the development of acute kidney injury, and its addition to clinical models improved overall predictive accuracy. "
09/01/2015 - "Neutrophil gelatinase associated lipocalin, also known as lipocalin-2, is a 25 kDa protein now considered the biochemical gold standard for the early diagnosis of acute kidney injury. "
02/01/2014 - "Acute kidney injury prediction improved when urine neutrophil gelatinase-associated lipocalin was added to a clinical model (area under the curve increased at 1 hr from 0.85 to 0.91 and at 3 hr to 0.92). "
02/01/2014 - "The efficacy of urine neutrophil gelatinase-associated lipocalin (uNGAL) as an early acute kidney injury (AKI) biomarker in preterm neonates was evaluated. "
01/01/2012 - "Although many studies have demonstrated spatiotemporal patterns of activation of gelatinases (MMP-9 and MMP-2) after ischemic stroke in young adult rodents, no data exist on MMP activity in old brains. "
09/18/2012 - "Since extracellular gelatinases in brain tissue are known to be neurotoxic during acute stroke, the contribution of intranuclear MMP-2 and -9 activities in neurons to neuronal apoptosis has been unclear. "
12/01/2011 - "Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation."
01/01/2007 - "In particular, early upregulation of the gelatinases MMP-2 and MMP-9 has been shown to contribute to disruption of the blood-brain barrier and to death of neurons in ischemic stroke. "
01/01/2005 - "These findings indicate that, at least acutely, neutrophils are not a significant contributor of gelatinase activity associated with acute neurovascular damage after stroke."
01/01/2008 - "In contrast, mice treated with a broad gelatinase inhibitor showed rather inferior protection against I/R injury and were characterized by persistent ongoing liver inflammation, suggesting that MMP-2 and MMP-9 may have distinct roles in this type of injury. "
09/01/2014 - "Plasma neutrophil gelatinase-associated lipocalinin in the general population: association with inflammation and prognosis."
09/01/2012 - "In experimental models of and humans with intestinal inflammation, increased levels of the matrix-degrading gelatinases MMP-2 and -9 in inflamed tissues can be detected. "
01/01/2012 - "Protein markers for inflammation and adhesion, gelatinase activity, and blood brain barrier (BBB) disruption were determined. "
12/21/2009 - "Gelatinases may be useful targets for treatment of intestinal inflammation."
|5.||Neoplasm Metastasis (Metastasis)
05/01/2011 - "MMP9 is an important gelatinase involved in processes such as cell migration, invasion and metastasis. "
11/01/2010 - "UA inhibits the invasion and metastasis of HO-8910PM cells, probably through inhibiting the activity of gelatinase and the expressions of MMP-2 and MMP-9."
04/01/2009 - "Compound (S)-6 was also shown to inhibit gelatinase activities of MMP-2 and MMP-9 and in vivo lung metastasis in mice."
07/01/2008 - "Inhibition of the gelatinase activity of MMP9 decreased the number of metastases and restored the advantage that CCR5(-/-) mice have over wild-type mice. "
06/01/2006 - "The use of the highly selective gelatinase inhibitors holds the promise of effective intervention of metastases of PC to the bone."
|3.||SB 3CT compound
|5.||Biological Markers (Surrogate Marker)
|6.||ethylene sulfide (thiirane)
|8.||Matrix Metalloproteinase 9 (Gelatinase B)
|9.||Interleukin-18 (Interleukin 18)
|10.||Matrix Metalloproteinase 2 (Gelatinase A)
|2.||Drug Therapy (Chemotherapy)
|3.||Laser Therapy (Surgery, Laser)
|5.||Cardiopulmonary Bypass (Heart-Lung Bypass)