|1.||Kwak, Shin: 12 articles (05/2012 - 05/2003)|
|2.||Huganir, Richard L: 11 articles (10/2014 - 12/2004)|
|3.||Gmiro, V E: 11 articles (05/2014 - 09/2002)|
|4.||Sprengel, Rolf: 8 articles (10/2014 - 11/2004)|
|5.||Jensen, Frances E: 7 articles (05/2014 - 05/2004)|
|6.||Meador-Woodruff, James H: 7 articles (08/2013 - 12/2006)|
|7.||Magazanik, L G: 7 articles (03/2007 - 09/2002)|
|8.||Nicoll, Roger A: 6 articles (07/2015 - 07/2002)|
|9.||Wu, Jing: 6 articles (09/2014 - 10/2003)|
|10.||Levite, Mia: 6 articles (08/2014 - 11/2002)|
01/01/2015 - "Effects of IEM1460 are dependent on the model of seizures used, their ictogenic structures and developmental changes in subunit composition of AMPA receptors. "
09/01/2012 - "Learning Through Silence: Amping up Cognition After Neonatal Hypoxic Seizures Through AMPA Receptor Inhibition."
06/01/2012 - "Expression of AMPA receptor subunits in hippocampus after status convulsion."
06/17/2011 - "All together these data indicate that in mutant mice the hyperexcitability, that is at the basis of the insurgence of seizures, might be due to the enhanced glutamatergic neurotransmission caused by an altered KA and AMPA receptor functioning."
09/01/2009 - "Repeated seizures decreased GluR1-4 AMPA receptor subunit levels in all cortical layers with a relaitve increase in GluR1 subunits. "
07/01/1999 - "Thus, novel AMPA receptor antagonists may be useful for the treatment of stroke in humans."
04/17/2012 - "Here, we show that neuronal insults trigger activation of REST and CoREST in a clinically relevant model of ischemic stroke and that REST binds a subset of "transcriptionally responsive" genes (gria2, grin1, chrnb2, nefh, nfκb2, trpv1, chrm4, and syt6), of which the AMPA receptor subunit GluA2 is a top hit. "
10/01/2005 - "Therefore, targeting to the AMPA receptor subunit GluR2 can be considered a practical strategy for stroke therapy."
10/01/2005 - "AMPA receptor subunit GluR2 gates injurious signals in ischemic stroke."
09/05/2005 - "The effects of AMPA receptor antagonists in models of stroke and neurodegeneration."
|3.||Schizophrenia (Dementia Praecox)
01/01/2002 - "These data suggest that AMPA receptor potentiators may be therapeutically beneficial for treating cognitive deficits in a variety of disorders, particularly those that are associated with reduced glutamatergic signaling such as schizophrenia. "
01/01/2015 - "Recent advances in the identification and profiling of positive allosteric modulators of the AMPA receptor offer a potential way forward and the hope of a new treatment for schizophrenia. "
05/01/2013 - "In this study, we measured expression of AMPA receptors and the extent of their N-glycosylation using Western blot analysis in the dorsolateral prefrontal cortex in subjects with schizophrenia (N = 35) and a comparison group (N = 31). "
10/01/2008 - "The present study demonstrates the limbic system as the anatomical locus of alterations in AMPA receptor density after acute administration of PCP and may have implications for models of schizophrenia that focus on glutamatergic dysfunction in limbic cortical regions."
02/01/2007 - "This study attempted to address these issues by examining the expression of AMPA receptor subunits and splice variants in the DLPFC of two schizophrenia cohorts using quantitative PCR (qPCR) with normalization to the geometric mean of multiple endogenous controls. "
11/16/2015 - "Previous studies have additionally demonstrated a role for AMPA receptor signaling in the NAc in chronic pain states. "
01/01/2011 - "Previous studies have demonstrated that the enhanced levels of phosphorylated α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor GluR1 subunits at Serine-831 (pGluR1-Ser-831) and Serine-845 (pGluR1-Ser-845) in the spinal cord dorsal horn are involved in central sensitization of inflammatory pain. "
10/01/2008 - "In this study, involvement of peripheral AMPA receptors in mediating craniofacial muscle pain was investigated. "
01/01/2015 - "Microinjection of AMPA receptor inhibitor IEM1460 into the ACC inhibited visceral and spontaneous pain behaviors. "
01/01/2015 - "We found that visceral pain induced an increased expression of AMPA receptors (at the post synapses) in the ACC via an enhanced trafficking of the AMPA receptors to the membrane. "
|5.||Parkinson Disease (Parkinson's Disease)
05/01/2007 - "The present review summarises studies into the effects of AMPA receptor potentiators (with a focus on the biarylpropylsulfonamides) in rodent models of depression and Parkinson's disease."
05/01/2007 - "AMPA receptor potentiators: application for depression and Parkinson's disease."
02/20/2004 - "Therefore, we propose that AMPA receptor potentiators offer the potential of a new therapy to halt the progression and perhaps repair the degeneration in Parkinson's disease."
02/20/2004 - "We therefore hypothesised that an AMPA receptor potentiator may provide neurotrophic effects in rodent models of Parkinson's disease. "
08/01/2003 - "Therefore, we propose that AMPA receptor potentiators offer the potential of a new disease modifying therapy for Parkinson's disease."
|2.||AMPA Receptors (AMPA Receptor)
|3.||alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
|4.||Glutamic Acid (Glutamate)
|6.||2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)
|7.||Kainic Acid (Kainate)
|8.||Levodopa (L Dopa)
|9.||Glutamate Receptors (Glutamate Receptor)
|10.||Excitatory Amino Acids