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Superantigens

Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Networked: 679 relevant articles (10 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Schlievert, Patrick M: 22 articles (01/2016 - 12/2002)
2. Peterson, Marnie L: 10 articles (06/2014 - 04/2005)
3. Sriskandan, Shiranee: 10 articles (01/2014 - 01/2003)
4. Bachert, Claus: 10 articles (09/2012 - 05/2002)
5. Rajagopalan, Govindarajan: 7 articles (08/2015 - 02/2006)
6. McCormick, John K: 7 articles (09/2014 - 12/2002)
7. Kotb, Malak: 7 articles (05/2014 - 09/2002)
8. Schlievert, P M: 7 articles (08/2009 - 04/2000)
9. David, Chella S: 6 articles (08/2015 - 02/2006)
10. Leung, Donald Y M: 6 articles (07/2013 - 12/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Autoimmune Diseases (Autoimmune Disease)
3. Rheumatoid Arthritis
4. Shock
5. Bacterial Infections (Bacterial Infection)

Related Drugs and Biologics

1. Antigens
2. Antibodies
3. Intravenous Immunoglobulins (IVIG)
4. Monoclonal Antibodies
5. Epitopes
6. Enterotoxins
7. Immunoglobulin E (IgE)
8. T-Cell Antigen Receptors (T-Cell Receptor)
9. staphylococcal enterotoxin B
10. Staphylococcal enterotoxin A

Related Therapies and Procedures

1. Hemoperfusion
2. Immunotherapy
3. Catheters
4. Homologous Transplantation (Allograft)
5. Transplantation (Transplant Recipients)