Prostaglandin E Receptors (Prostaglandin E Receptor)

Cell surface receptors which bind prostaglandins with a high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin E receptors prefer prostaglandin E2 to other endogenous prostaglandins. They are subdivided into EP1, EP2, and EP3 types based on their effects and their pharmacology.

Also Known As:

Networked: 196 relevant articles (4 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Narumiya, Shuh: 17 articles (08/2020 - 01/2002)
2.	Sugimoto, Yukihiko: 9 articles (01/2019 - 01/2002)
3.	Narumiya, S: 9 articles (07/2011 - 04/2000)
4.	Maruyama, Takayuki: 9 articles (02/2010 - 01/2002)
5.	Kundu, Namita: 8 articles (01/2017 - 03/2006)
6.	Ma, Xinrong: 8 articles (01/2017 - 03/2006)
7.	Sugimoto, Y: 8 articles (02/2010 - 04/2000)
8.	Fulton, Amy M: 7 articles (01/2017 - 03/2006)
9.	Wakabayashi, Keiji: 6 articles (01/2006 - 01/2002)
10.	Majima, Masataka: 5 articles (08/2020 - 10/2006)

Related Diseases

1.	Endometriosis 08/04/2015 - "The objective of the present study was to determine the effects of pharmacological inhibition of PGE2 receptors, EP2 and EP4, on molecular and cellular aspects of the pathogenesis of endometriosis and associated clinical symptoms. " 08/04/2015 - "Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis." 02/01/2018 - "The primary aim of this study was to explore the underlying mechanisms that affect the growth and function of endometrial epithelium and stroma by assessing the staining intensity of PGE2 receptors (EP) in healthy endometrium across the menstrual cycle and in pathological endometrium, such as ovarian endometriosis and endometrial cancer. " 01/01/2021 - "The expression of PGE2 receptors (EP2 and EP4) in donated tissues from human ovarian endometriosis, adenomyosis and peritoneal endometriosis was examined using immunohistochemistry. " 12/01/2022 - "The objective of the present study is to determine the effects of pharmacological inhibition of PGE2 receptors, EP2 and EP4, on miRNA profile in endometriosis. "
2.	Ischemia 01/01/2006 - "Together, these results suggest that modulation of PGE2 receptors that increase cAMP levels and activate extracellular-regulated kinases 1/2 caused by treatment with 1-OHPGE1 can be protective against neuronal injury induced by focal ischemia." 06/01/2020 - "Prostaglandin E receptor subtype 4 (EP4) is widely distributed in the heart, but its role in hepatic ischemia/reperfusion (I/R), particularly in mitochondrial permeability transition pore (MPTP) modulation, is yet to be elucidated. " 01/01/2020 - "Here, we subjected EP3-deficient (Ptger3-/- ) and wild-type (WT) mice to hepatic ischemia-reperfusion (I/R) and demonstrate that signaling via the prostaglandin E (PGE) receptor EP3 in DCs regulates macrophage plasticity during liver repair. " 01/01/2020 - "To investigate the function and expression of the PGE2 receptors EP1-4 in rat retinal ischemia-reperfusion (I/R) injury and to determine the regulatory role of resveratrol (RES) in this process. " 07/01/2009 - "Expression of prostaglandin PGE2 receptors under conditions of aging and stress and the protective effect of the EP2 agonist butaprost on retinal ischemia."
3.	Infections 06/01/2011 - "Paraventricular nucleus of the hypothalamus (PVH), parabrachial nucleus (PBN), and nucleus tractus solitarius (NTS) neurons also express PGE receptors and are activated during systemic pathogen infection. " 01/01/1999 - "Modulation of the prostaglandin E receptor: a possible mechanism for infection-induced preterm labor." 11/01/2006 - "In this review, we first briefly summarize current views on the mechanism of sensing microbial infection by the nervous system, and the roles of prostaglandin E2 (PGE2) and its receptors in fever; then we focus on the neural circuits underlying fever generation, particularly their relationship with the distribution of PGE2 receptors within the CNS. " 04/17/2014 - "Targeted PGE2 suppression via genetic ablation of microsomal prostaglandin E-synthase 1 (mPGES-1) or by the pharmacological inhibition of PGE2 receptors EP2 and EP4 substantially improved survival against lethal IAV infection whereas PGE2 administration reversed this phenotype. "
4.	Premature Obstetric Labor (Premature Labor) 02/01/2010 - "Elucidating the regulation of PGE2 receptors may facilitate improved approaches to the prevention and treatment of preterm labor." 02/01/2012 - "PGE receptors, EP1 and EP3, may each mediate contractions, and represent potential therapeutic targets in the management of preterm labor. " 01/01/1999 - "Modulation of the prostaglandin E receptor: a possible mechanism for infection-induced preterm labor."
5.	Neoplasms (Cancer) 10/01/2018 - "While the influence of COX-2 activity and PGE2 receptors have been evaluated extensively in human cancer, their role in veterinary oncology still needs to be elucidated." 07/15/2015 - "Deficiency of PGE receptor subtype EP2 selectively reduced, and deficiency of EP1 and EP3 enhanced, the tumor formation. " 01/01/2014 - "The PGE2 receptors EP1-4 regulate tumor cell growth, invasion and migration in different tumor entities but EP expression in BCA remains to be determined. " 07/01/2010 - "We previously reported that the PGE receptor EP3 is expressed in bone marrow (BM) derived cells, enriched in stromal tissue, and enhances the potential for tumor angiogenesis. " 09/01/1991 - "PGE2 receptors were examined on both unfractionated and monocyte-macrophage-depleted splenocytes of normal or tumor-bearing C3H/HeJ mice (at 25 days following s.c. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	Prostaglandins
3.	Cyclooxygenase 2 (Cyclooxygenase-2)
4.	Messenger RNA (mRNA)
5.	Prostaglandin-E Synthases
6.	Phosphotransferases (Kinase)
7.	Prostaglandins E
8.	ONO 8711
9.	Azoxymethane
10.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Castration