Tympanic Membrane Perforation

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110 relevant articles (5 outcomes, 19 trials/studies) found for this Disease

Description: A temporary or persistent opening in the eardrum (TYMPANIC MEMBRANE). Clinical signs depend on the size, location, and associated pathological condition.

Also Known As:

Membrane Perforation, Tympanic; Membrane Rupture, Tympanic; Perforation, Eardrum; Rupture, Tympanic Membrane; Eardrum Perforation; Tympanic Membrane Rupture

Relationship Network

Disease Context: Research Results

Otorhinolaryngologic Diseases: 123

Ear Diseases: 115

Tympanic Membrane Perforation: 110

Disorders of Environmental Origin

Wounds and Injuries: 60616

Tympanic Membrane Perforation: 110

Related Diseases

1.	Otitis Media
2.	Otitis Externa
3.	Blast Injuries
4.	Cholesteatoma
5.	Cicatrix
14 Diseases and 24 more articles analyzed in the Research Interface, order at left...

Experts

1.	Chen, Feng: 2 articles (05/2008 - 02/2008)
2.	Joseph, Theo: 1 article (05/2008)
3.	Buchler, Tomas: 1 article (05/2008)
4.	Lee, Slow Ming: 1 article (05/2008)
5.	Lai, Cecilia: 1 article (05/2008)
6.	Dai, Yanhong: 1 article (05/2008)
7.	She, Wandong: 1 article (05/2008)
8.	Ding, Xiaoqiong: 1 article (05/2008)
9.	Qin, Daofen: 1 article (05/2008)
10.	et al, : 1 article (02/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tympanic Membrane Perforation:

1.	SiliconesIBA 08/01/2003 - "CONCLUSION: The study demonstrated that bFGF combined with an atelocollagen/silicone bilayer membrane is effective for the conservative treatment of tympanic membrane perforation." Get all the results and reference details, order at left...
2.	atelocollagenIBA 08/01/2003 - "CONCLUSION: The study demonstrated that bFGF combined with an atelocollagen/silicone bilayer membrane is effective for the conservative treatment of tympanic membrane perforation." Get all the results and reference details, order at left...
3.	Ofloxacin (Levofloxacin)FDA LinkGeneric 01/01/2001 - "Because a number of cases of otitis externa are complicated by an undiagnosed tympanic membrane perforation, the lack of ototoxicity associated with ofloxacin otic makes it a particularly safe option for use in these patients." 10/01/2007 - "Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing." Get all the results and reference details, order at left...
4.	FluoroquinolonesIBA 10/15/2000 - "For the treatment of otitis media with tympanic membrane perforation, topical fluoroquinolones are effective and safe" Get all the results and reference details, order at left...
5.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 03/01/1993 - "Histological study of the healing of traumatic tympanic membrane perforation after basic fibroblast growth factor application." 07/01/1993 - "Direct application of basic fibroblast growth factor improves tympanic membrane perforation healing." 01/01/1995 - "The beneficial effects of basic fibroblast growth factor (bFGF or FGF-2) in healing of tympanic membrane (TM) perforations have been demonstrated in animal models, and this study was conducted to investigate the effect of neutralizing anti-FGF-2 antibodies on acute tympanic membrane perforation healing" 07/01/2002 - "Direct application of keratinocyte growth factor, basic fibroblast growth factor and transforming growth factor-alpha during healing of tympanic membrane perforation in glucocorticoid-treated rats." Get all the results and reference details, order at left...
6.	Mitomycin (Mitomycin-C)FDA LinkGeneric 08/01/2004 - "RESULTS: Only by additional partial excision of the handle of malleus followed by local application of mitomycin were we able to achieve a persistent tympanic membrane perforation" 01/01/2001 - "SIGNIFICANCE: Myringotomy with concurrent mitomycin C application may be useful for creating an animal model for chronic tympanic membrane perforation and should be tested in human beings as a method to maintain myringotomy patency for long-term ventilation." 01/01/2001 - "OBJECTIVE: To determine the ability of topically applied mitomycin C to create a stable tympanic membrane perforation" 01/01/2001 - "Creating a stable tympanic membrane perforation using mitomycin C." 09/01/2005 - "BACKGROUND: The purpose of this study was to determine whether systemic glucocorticoid application, in combination with topical mitomycin or dexamethasone, prolongs the patency of a tympanic membrane perforation" Get all the results and reference details, order at left...
7.	Hyaluronic Acid (Hyaluronan)IBA 01/01/1992 - "In experimental animal studies, exogenous hyaluronan (HA) has been shown to exert beneficial effects on the healing of tympanic membrane perforation" 12/01/2006 - "CONCLUSIONS: Our results support the proposition that hyaluronic acid (HA) provides a moist wound-healing environment to aid in the healing process of tympanic membrane perforation" 01/01/1992 - "Animal experiments have recently shown that local treatment with steroids delays the healing of a tympanic membrane perforation, whereas hyaluronan (hyaluronic acid) improves the healing rate as well as the quality of the scar" 05/01/2003 - "The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation." Get all the results and reference details, order at left...
8.	Epidermal Growth Factor (EGF)IBA 06/01/2005 - "Treatment of an acute tympanic membrane perforation with EGF releasing film]" 06/01/2005 - "RESULTS: By day 6, complete closure of the tympanic membrane perforation was achieved in 56% of the EGF group, whereas it was achieved in only 10% in the control group" 06/01/2005 - "BACKGROUND: The aim of this study was to evaluate the effects of an alginate matrix releasing epidermal growth factor on healing after acute tympanic membrane perforation in rats" 05/01/2003 - "The effects of hyaluronic acid, epidermal growth factor, and mitomycin in an experimental model of acute traumatic tympanic membrane perforation." Get all the results and reference details, order at left...
9.	Dexamethasone (Maxidex)FDA LinkGeneric 09/01/2005 - "BACKGROUND: The purpose of this study was to determine whether systemic glucocorticoid application, in combination with topical mitomycin or dexamethasone, prolongs the patency of a tympanic membrane perforation" 10/01/2007 - "Effects of ciprofloxacin/dexamethasone and ofloxacin on tympanic membrane perforation healing." Get all the results and reference details, order at left...
10.	AllodermIBA 07/01/2000 - "Tympanic membrane perforation repair using AlloDerm." 01/01/2003 - "PURPOSE: To study the effectiveness of AlloDerm (LifeCell Corporation, Branchburg, NJ) as a graft material in underlay tympanoplasty by comparison to autologous fascia in a chronic tympanic membrane perforation animal model" Get all the results and reference details, order at left...
47 Drugs and Important Bio-Agents and 55 more articles analyzed in the Research Interface, order at left...

Therapies and Procedures

1.	Transplants (Transplant) 03/01/2004 - "The pieces of graft material under study were removed after 5 days, leaving the graft used to seal the tympanic membrane perforation undisturbed" 05/31/2001 - "Thirty patients were included in this study over a period of 2 years, where cartilage perichondrium composite graft (CPCG) was used to close the tympanic membrane perforation" 11/01/2006 - "Repair of tympanic membrane perforation using a modified cartilage-perichondrium composite ring graft." 12/01/2002 - "The characteristics more frequently seen for operating ears were central localization of tympanic membrane perforation, dry ear, good eustaquian tube function and underlay technique placing fascia graft" 02/01/1988 - "This update of a previously reported paper reinforces our opinion that the 3-F graft is an effective tool for the closure of tympanic membrane perforation with or without ossicular chain reconstruction." Get all the results and reference details, order at left...
2.	Myringoplasty 08/01/2001 - "One group of subjects had a tympanic membrane perforation and was recruited to the study before admission for myringoplasty" 05/01/2008 - "OBJECTIVE: To evaluate the effect of over-under myringoplasty technique on repairing tympanic membrane perforation regarding with the rate of perforation closure, the frequency of postoperative complications occurrence and the level of hearing improvement" 05/01/2008 - "Comparative evaluation of over-under myringoplasty and underlay myringoplasty for repairing tympanic membrane perforation]" 04/01/2008 - "A relatively smaller tympanic membrane perforation, a relatively shorter duration of disease and a relatively longer period of dry ear of disease were found to be significant prognostic factors positively influencing the success rate of myringoplasty." 04/01/2008 - "The effect of prognostic factors on myringoplasty were investigated by variables noted from patients' files such as age, sex, causes of disease, duration of disease, period of dry ear of disease, operation types, places of tympanic membrane perforation, size of tympanic membrane perforation, status of middle ear and status of eardrum" Get all the results and reference details, order at left...
3.	Tubal Sterilization (Tubal Ligation) 01/01/2001 - "The major cause for postoperative tympanic membrane perforation and tubal occlusion was the pathogenic damage being not cleared up thoroughly and/or there being nasal cavity or pharyngeal cavity pathogenic changes accompanied" Get all the results and reference details, order at left...
4.	Tympanoplasty 10/01/2001 - "OBJECTIVE: This study was designed to identify the external ear resonance characteristics of patients with tympanic membrane perforation and to investigate subsequent changes in external ear resonance, depending on the length of the postoperative period and which of 3 different types of operation was performed: tympanoplasty with canal wall-up mastoidectomy, epitympanoplasty, and canal wall-down mastoidectomy" 08/01/2008 - "Patients with tympanic membrane perforation or previous tympanoplasty with ossicular discontinuity did not show any response" 05/01/2008 - "PATIENTS: A total of 1121 patients with central tympanic membrane perforation were evaluated after tympanoplasty" 09/01/2006 - "METHODS: Patients were those presenting with total or near-total tympanic membrane perforation undergoing lateral tympanoplasty from 1999 to 2004" 09/01/2006 - "OBJECTIVE: To identify prognostic factors affecting outcome in lateral tympanoplasty for total or near-total tympanic membrane perforation" Get all the results and reference details, order at left...
5.	Hydrocolloid Bandages (Duoderm) 01/01/1992 - "In a rat study, an occlusive double-layer transparent hydrocolloid dressing, Duo-DERM, was compared with a rice paper dressing in the treatment of tympanic membrane perforation" Get all the results and reference details, order at left...
21 Therapies and Procedures and 65 more articles analyzed in the Research Interface, order at left...

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