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Bispecific Antibodies

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Also Known As:
Antibodies, Bispecific; Bispecific Monoclonal Antibodies; Antibodies, Bifunctional; Antibodies, Bispecific Monoclonal; Monoclonal Antibodies, Bispecific; Bifunctional Antibodies
Networked: 968 relevant articles (74 outcomes, 89 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Cheung, Nai-Kong V: 15 articles (01/2022 - 01/2014)
2. Klein, Christian: 15 articles (01/2022 - 10/2012)
3. Lum, Lawrence G: 13 articles (01/2022 - 01/2004)
4. Goldenberg, David M: 12 articles (02/2015 - 05/2002)
5. Asano, Ryutaro: 11 articles (11/2021 - 03/2002)
6. Bacac, Marina: 10 articles (01/2022 - 02/2016)
7. Baeuerle, Patrick A: 10 articles (01/2022 - 08/2003)
8. Wang, Zhong: 10 articles (01/2020 - 11/2015)
9. Sam, Johannes: 9 articles (01/2022 - 01/2016)
10. Kontermann, Roland E: 9 articles (11/2021 - 01/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Multiple Myeloma
3. Hematologic Neoplasms (Hematological Malignancy)
4. Lymphoma (Lymphomas)
5. Bites and Stings (Sting)

Related Drugs and Biologics

1. Chimeric Antigen Receptors
2. Antigens
3. Antibodies
4. Immunoconjugates (Immunoconjugate)
5. Monoclonal Antibodies
6. B-Cell Maturation Antigen
7. bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amine
8. Immune Checkpoint Inhibitors
9. blinatumomab
10. Immunotoxins (Immunotoxin)

Related Therapies and Procedures

1. Immunotherapy
2. Therapeutics
3. Drug Therapy (Chemotherapy)
4. Biological Therapy
5. Cell- and Tissue-Based Therapy (Cell Therapy)