Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)

Cell surface proteins that bind corticotropin-releasing hormone with high affinity and trigger intracellular changes which influence the behavior of cells. The corticotropin releasing-hormone receptors on anterior pituitary cells mediate the stimulation of corticotropin release by hypothalamic corticotropin releasing factor. The physiological consequence of activating corticotropin-releasing hormone receptors on central neurons is not well understood.

Also Known As:

Corticotropin Releasing-Hormone Receptor; Receptors, Corticotropin-Releasing Hormone; CRF Receptor; CRF Receptors; CRH Receptor; Corticotropin Releasing-Factor Receptors; Receptors, CRF; Corticotropin Releasing Factor Receptor; Corticotropin Releasing Factor Receptors; Corticotropin Releasing Hormone Receptor; Corticotropin Releasing Hormone Receptors; Hormone Receptors, Corticotropin-Releasing; Receptor, CRF; Receptor, CRH; Receptor, Corticotropin Releasing-Factor; Receptor, Corticotropin Releasing-Hormone; Receptors, Corticotropin Releasing Hormone; Receptors, Corticotropin Releasing-Factor; Receptors, Corticotropin Releasing-Hormone; Releasing-Factor Receptor, Corticotropin; Releasing-Factor Receptors, Corticotropin; Releasing-Hormone Receptor, Corticotropin; Releasing-Hormone Receptors, Corticotropin; CRH Receptors; Corticotropin Releasing-Factor Receptor; Corticotropin Releasing-Hormone Receptors; Receptors, CRH

Networked: 431 relevant articles (14 outcomes, 66 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125

Experts

1.	Taché, Yvette: 11 articles (03/2013 - 01/2002)
2.	Holsboer, Florian: 10 articles (07/2014 - 12/2003)
3.	Li, Shengnan: 7 articles (01/2019 - 11/2007)
4.	Müller, Marianne B: 7 articles (07/2014 - 01/2004)
5.	Million, Mulugeta: 7 articles (03/2013 - 01/2002)
6.	Chatzaki, Ekaterini: 6 articles (06/2021 - 01/2009)
7.	Bhargava, Aditi: 6 articles (01/2019 - 07/2013)
8.	Chen, Xue-Qun: 6 articles (03/2015 - 04/2005)
9.	Du, Ji-Zeng: 6 articles (03/2015 - 04/2005)
10.	Wurst, Wolfgang: 6 articles (06/2013 - 10/2003)

Related Diseases

1.	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 06/21/2014 - "This study is the first to assess the efficacy of a specific antagonist of a CRH receptor in the treatment of PTSD. " 01/01/2020 - "The current study suggests that CRF receptor 1 antagonism may have specific effects within neural circuitry mediating fear inhibition responses, but not overall symptom presentation, in PTSD." 06/01/2018 - "Here, we examine placebo effects across self-reported, clinically rated, and performance-based data from a trial using a corticotropin-releasing hormone receptor type 1 (CRHR1) antagonist for treatment of post-traumatic stress disorder (PTSD). " 10/01/2013 - "This study examined the relationship between 12 single nucleotide polymorphisms (SNPs) in the corticotropin-releasing hormone receptor 1 gene (CRHR1) and post-disaster PTSD symptoms and diagnosis in adults exposed to 2004 Florida hurricanes. " 12/01/2017 - "Previously, we observed abnormal expression of corticotropin-releasing factor receptor type 2 (CRFR2) to be associated with post-traumatic stress disorder (PTSD)-like symptoms. "
2.	Ischemia 01/06/2006 - "However, a number of issues remain to be clarified from these studies, including the relative contribution of CRH receptor subtypes, and the efficacy of these compounds to alter ischemia-induced behavioral impairments. " 12/01/2002 - "Therefore, in the present study, we investigated the temporal and spatial changes in CRF receptor immunoreactivity in the hippocampus and the neocortex after transient ischemia. " 10/01/2016 - "The gene expression of CRF, CRF receptor 1, and CRF receptor 2 was observed in the small intestine, and remained unchanged following ischemia/reperfusion. " 12/01/2002 - "On the other hand, in the neocortex, 3h after transient ischemia, the CRF receptor immunoreactivity was elevated in regions vulnerable to ischemia. " 12/01/2002 - "However, little experimental data currently links the CRF receptor directly to neuronal death induced by ischemia. "
3.	Mood Disorders (Mood Disorder) 03/26/1997 - "These data support evidence implicating stress systems in the pathophysiology of depression, and suggest potential efficacy of small-molecule CRF receptor antagonists in the treatment of affective disorders." 06/01/2004 - "Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders." 01/01/2018 - "We aimed to investigate a potential association between childhood trauma and previous suicide attempts in affective disorder patients, moderated by variants of the corticotropin-releasing hormone receptor 1 (CRHR1) gene. " 06/01/2013 - "Previous reports have identified interactions between childhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affective disorders. " 01/01/2005 - "Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders."
4.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 01/01/2019 - "Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity." 11/01/2016 - "Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response." 01/01/2016 - "Corticotropin-Releasing Hormone Receptor 2 Gene Variants in Irritable Bowel Syndrome." 08/01/2015 - "Corticotropin-releasing factor receptor type 1 and type 2 interaction in irritable bowel syndrome." 01/01/2012 - "Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome."
5.	Shock 08/07/1992 - "This study examined in rats whether antagonism of CRF receptors in the region of locus coeruleus (LC) plays a role in reducing freezing induced by electric foot shock. " 08/07/1992 - "Antagonism of corticotropin-releasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats." 02/12/1990 - "Because exposure to stress is reported to have long-term behavioral and physiological effects, we examined whether central administration of the synthetic CRH receptor antagonist, alpha-helical CRH(9-41), would also alter fear-motivated behavioral and hormonal responses occurring 24 h after exposure to electric foot shock. " 02/12/1990 - "In earlier studies, we established that in rats, antagonism of corticotropin-releasing hormone (CRH) receptors reduced the occurrence of fear-motivated behavior displayed immediately after administration of electric foot shock. " 04/01/2013 - "In experiment 1, rats received microinjections of 0.5 μL antalarmin (1.61 or 4.82 mM), a CRF receptor 1 antagonist, or distilled water once a week for 3 wk. In experiment 2, rats received a microinjection of either antalarmin or vehicle prior to inescapable shock training (ST; 20 shocks; 0.8 mA, 0.5 sec; 1 min interstimulus interval). "

Related Drugs and Biologics

1.	Urocortins
2.	Corticotropin-Releasing Hormone
3.	Peptides (Polypeptides)
4.	Corticosterone
5.	Ligands
6.	Prebiotics
7.	Urotensins
8.	Progesterone
9.	Lidocaine (Xylocaine)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Analgesia
3.	Intraperitoneal Injections
4.	Injections
5.	Electroacupuncture