|1.||Taché, Yvette: 8 articles (01/2012 - 09/2003)|
|2.||Li, Shengnan: 6 articles (08/2014 - 11/2007)|
|3.||Holsboer, Florian: 6 articles (07/2014 - 01/2004)|
|4.||Theoharides, Theoharis C: 5 articles (11/2014 - 07/2007)|
|5.||Müller, Marianne B: 5 articles (07/2014 - 01/2004)|
|6.||Navarra, Pierluigi: 4 articles (09/2015 - 03/2002)|
|7.||Jin, Lai: 4 articles (08/2014 - 06/2012)|
|8.||Binder, Elisabeth B: 4 articles (07/2014 - 06/2005)|
|9.||Nemeroff, Charles B: 4 articles (01/2014 - 09/2007)|
|10.||Holsboer, F: 4 articles (01/2014 - 01/2001)|
|1.||Post-Traumatic Stress Disorders (PTSD)
01/01/2014 - "This study is the first to assess the efficacy of a specific antagonist of a CRH receptor in the treatment of PTSD. "
10/01/2013 - "This study examined the relationship between 12 single nucleotide polymorphisms (SNPs) in the corticotropin-releasing hormone receptor 1 gene (CRHR1) and post-disaster PTSD symptoms and diagnosis in adults exposed to 2004 Florida hurricanes. "
12/01/2013 - "Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women."
07/01/2010 - "CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD."
04/15/2007 - "These results are consistent with a model of downregulation of CRF receptors in an environment of chronically increased CRF activity or with enhanced negative feedback regulation in PTSD."
01/06/2006 - "However, a number of issues remain to be clarified from these studies, including the relative contribution of CRH receptor subtypes, and the efficacy of these compounds to alter ischemia-induced behavioral impairments. "
12/01/2002 - "Therefore, in the present study, we investigated the temporal and spatial changes in CRF receptor immunoreactivity in the hippocampus and the neocortex after transient ischemia. "
12/01/2002 - "On the other hand, in the neocortex, 3h after transient ischemia, the CRF receptor immunoreactivity was elevated in regions vulnerable to ischemia. "
12/01/2002 - "However, little experimental data currently links the CRF receptor directly to neuronal death induced by ischemia. "
10/12/2013 - "Estrogens protect myocardium against ischemia/reperfusion insult by up-regulation of CRH receptor type 2 in female rats."
|3.||Mood Disorders (Mood Disorder)
03/26/1997 - "These data support evidence implicating stress systems in the pathophysiology of depression, and suggest potential efficacy of small-molecule CRF receptor antagonists in the treatment of affective disorders."
06/01/2004 - "Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders."
12/01/2012 - "Because CRF receptors are expressed in sex steroid-sensitive areas of the forebrain, they may contribute to sex-specific patterns of stress sensitivity and susceptibility to stress-related mood disorders, which are more frequent in women. "
01/01/2005 - "Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders."
08/01/2004 - "Getting closer to affective disorders: the role of CRH receptor systems."
|4.||Wounds and Injuries (Trauma)
09/01/2009 - "A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]). "
01/01/2009 - "Variations of the corticotropin-releasing hormone receptor 1 (CRHR1) gene appear to moderate the development of depression after childhood trauma. "
01/01/2009 - "Effect of Childhood Trauma on Adult Depression and Neuroendocrine Function: Sex-Specific Moderation by CRH Receptor 1 Gene."
12/01/2002 - "Our results indicate that neonatal trauma can induce phenotypic changes in adulthood, including enhanced vulnerability of the gut mucosa to stress via mechanisms involving peripherally located CRH receptors."
06/01/2013 - "Previous reports have identified interactions between childhood trauma and sequence variation in the CRH receptor 1 gene (CRHR1) that increase risk for affective disorders. "
08/07/1992 - "This study examined in rats whether antagonism of CRF receptors in the region of locus coeruleus (LC) plays a role in reducing freezing induced by electric foot shock. "
08/07/1992 - "Antagonism of corticotropin-releasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats."
02/12/1990 - "Because exposure to stress is reported to have long-term behavioral and physiological effects, we examined whether central administration of the synthetic CRH receptor antagonist, alpha-helical CRH(9-41), would also alter fear-motivated behavioral and hormonal responses occurring 24 h after exposure to electric foot shock. "
02/12/1990 - "In earlier studies, we established that in rats, antagonism of corticotropin-releasing hormone (CRH) receptors reduced the occurrence of fear-motivated behavior displayed immediately after administration of electric foot shock. "
04/01/2013 - "In experiment 1, rats received microinjections of 0.5 μL antalarmin (1.61 or 4.82 mM), a CRF receptor 1 antagonist, or distilled water once a week for 3 wk. In experiment 2, rats received a microinjection of either antalarmin or vehicle prior to inescapable shock training (ST; 20 shocks; 0.8 mA, 0.5 sec; 1 min interstimulus interval). "
|7.||Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)
|8.||Adrenocorticotropic Hormone (ACTH)
|9.||Messenger RNA (mRNA)
|10.||Carrier Proteins (Binding Protein)
|1.||Drug Therapy (Chemotherapy)
|3.||Intensive Care (Surgical Intensive Care)