Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)

Cell surface proteins that bind CALCITONIN GENE-RELATED PEPTIDE with high affinity and trigger intracellular changes which influence the behavior of cells. CGRP receptors are present in both the CENTRAL NERVOUS SYSTEM and the periphery. They are formed via the heterodimerization of the CALCITONIN RECEPTOR-LIKE PROTEIN and RECEPTOR ACTIVITY-MODIFYING PROTEIN 1.

Also Known As:

Networked: 407 relevant articles (42 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Edvinsson, Lars: 30 articles (10/2022 - 05/2002)
2.	Reuter, Uwe: 21 articles (07/2022 - 12/2009)
3.	Goadsby, Peter J: 15 articles (11/2019 - 08/2004)
4.	Tepper, Stewart J: 12 articles (01/2022 - 09/2008)
5.	Ashina, Messoud: 11 articles (01/2021 - 01/2010)
6.	Messlinger, Karl: 10 articles (03/2018 - 06/2006)
7.	Mikol, Daniel D: 9 articles (01/2021 - 09/2017)
8.	Warfvinge, Karin: 9 articles (01/2021 - 01/2011)
9.	Xu, Cen: 9 articles (01/2021 - 12/2007)
10.	Raffaelli, Bianca: 8 articles (10/2022 - 01/2018)

Related Diseases

1.	Migraine Disorders (Migraine) 01/01/2021 - "Zavegepant (BHV-3500, BMS-742413) is a high affinity antagonist of the CGRP receptor (hCGRP Ki = 0.023 nM) that has demonstrated efficacy in the acute treatment of migraine with intranasal delivery in a Phase 2/3 trial, despite showing low oral bioavailability in rats (FPO = 1.7%). " 03/26/2010 - "Multiple lines of evidence have implicated CGRP in the pathophysiology of migraine headache making the CGRP receptor an attractive target for development of small-molecule antagonists as a novel treatment for this debilitating condition. " 09/01/2008 - "Based on these findings, it was proposed that blockage of CGRP receptor function and, hence, the physiological effects of CGRP would be effective in aborting a migraine attack. " 12/01/2021 - "Two commercially available oral drugs that block CGRP receptors (‘gepants’) have reduced symptoms during migraine attacks in clinical trials. " 01/01/2021 - "Based on the study results, the present review suggests that the inhibition of the CGRP receptor might be a successful way to treat migraine headaches. "
2.	Headache (Headaches) 12/31/2021 - "We aimed to evaluate headache-specific and generic HRQoL for three months after discontinuation of CGRP(-receptor) mAb treatment. " 01/01/2018 - "While CGRP-mediated activation of meningeal afferents evoked by cortical efflux of K+ could promote headache, acute activation of CGRP receptors may not play a key role in mediating CSD-evoked headache." 12/01/2009 - "Delayed headaches induced by NO may change CGRP or CGRP-receptor expression." 04/01/2009 - "Spinal trigeminal activity was significantly reduced within minutes and to a similar extent as previously reported in animals not treated with NO. Slow continuous NO infusion may be a model of the active headache phase, and inhibition of CGRP receptors can reverse the induced neuronal activity." 03/20/2008 - "Thus, in the trigeminovascular system CGRP receptor localization suggests multiple targets for CGRP in the pathogenesis of primary headaches."
3.	Pain (Aches) 09/01/2009 - "Studies demonstrate that CGRP and CGRP receptors are involved in the transmission and modulation of pain information in peripheral and central nervous system. " 07/01/2009 - "The present results provide evidence for the participation of ionotropic glutamatergic receptors and CGRP receptors in the hyperalgesic responses to exogenous ET-1 and suggest clinically relevant targets for further study of elevated pain caused by release of endogenous ET-1." 01/01/2020 - "Interestingly, both CGRP-induced antinociception and CGRP receptor expression decreased in ACC in rats with inflammatory pain compared with naïve rats. " 01/01/2020 - "There are high expressions of CGRP and CGRP receptor in anterior cingulate cortex (ACC), an important brain structure in pain modulation. " 01/01/2019 - "The viewpoint presented here focuses further on the activation of the CGRP receptor on the sensory Aδ-fiber, leading to the sensation of pain. "
4.	Cluster Headache (Cluster Headaches) 12/01/2020 - "Data from 22 chronic cluster headache patients who received at least one dose of a calcitonin gene-related peptide(-receptor) antibody and recorded attack frequency in a headache diary were retrospectively collected at eight headache centres. " 12/01/2020 - "Under real-world conditions, individual treatment with calcitonin gene-related peptide(-receptor) antibodies was effective in 55% of our chronic cluster headache patients. " 12/01/2020 - "Effect of calcitonin gene-related peptide (-receptor) antibodies in chronic cluster headache: Results from a retrospective case series support individual treatment attempts." 12/01/2020 - "This finding supports individual off-label treatment attempts with calcitonin gene-related peptide-(receptor) antibodies in chronic cluster headache patients insufficiently responding to other therapies." 12/01/2020 - "Although the randomised controlled trial with the calcitonin gene-related peptide antibody galcanezumab was negative, chronic cluster headache patients with insufficient response to other preventive treatments have been receiving individual off-label treatment attempts with calcitonin gene-related peptide-(receptor) antibodies. "
5.	Sepsis (Septicemia) 01/01/2022 - "This study evaluated whether CGRP receptor antagonism is similarly beneficial in a porcine model of polymicrobial sepsis. " 01/01/2022 - "Systemic calcitonin gene-related peptide receptor antagonism decreases survival in a porcine model of polymicrobial sepsis: blinded randomised controlled trial." 01/01/2022 - "CGRP receptor antagonism with olcegepant was not beneficial in this porcine model of polymicrobial sepsis, which closely mimics human sepsis." 01/01/2021 - "In addition, the study points towards the calcitonin gene-related peptide receptor as relevant for procalcitonin signaling and suggests a potential therapeutic application for calcitonin gene-related peptide receptor inhibitors in sepsis, which warrants further clinical investigation." 01/01/2022 - "Calcitonin gene-related peptide (CGRP) and procalcitonin, which are overexpressed in sepsis, exert distinct immunomodulatory effects mediated through the CGRP receptor. "

Related Drugs and Biologics

1.	Monoclonal Antibodies
2.	erenumab
3.	Calcitonin Gene-Related Peptide
4.	Calcitonin Gene-Related Peptide Receptor Antagonists
5.	Antibodies
6.	olcegepant
7.	galcanezumab
8.	fremanezumab
9.	Nitric Oxide Synthase (NO Synthase)
10.	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Complementary Therapies (Alternative Medicine)
3.	Ligation
4.	Withholding Treatment
5.	Vagotomy