Glycine Receptors (Glycine Receptor)

Cell surface receptors that bind GLYCINE with high affinity and trigger intracellular changes which influence the behavior of cells. Glycine receptors in the CENTRAL NERVOUS SYSTEM have an intrinsic chloride channel. GlyA receptor is sensitive to STRYCHNINE and localized in the post-synaptic membrane of inhibitory glycinergic neurons. GlyB receptor is insensitive to strychnine and associated with the excitatory NMDA receptor.

Also Known As:

Glycine Receptor; Receptors, Glycine; Glycine Receptor, Inhibitory; Glycine Receptor, Strychnine-Insensitive; Glycine Receptor, Strychnine-Sensitive; Receptor, Glycine; Receptor, Inhibitory Glycine; Receptor, SIG; Receptor, Strychnine-Insensitive Glycine; Receptor, Strychnine-Sensitive Glycine; Receptors, GlyB; Strychnine Insensitive Glycine Receptor; Strychnine Sensitive Glycine Receptor; Excitatory Glycine Receptors; GlyA Receptors; GlyB Receptors; Glycine A Receptors; Glycine B Receptors; Glycine Receptor alpha1; Inhibitory Glycine Receptor; SIG Receptor; Strychnine-Insensitive Glycine Receptor; Strychnine-Sensitive Glycine Receptor

Networked: 484 relevant articles (6 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Chloride Channels: 1799
        Glycine Receptors: 484
        glycine receptor alpha3 subunit: 6
        strychnine receptor: 2
        alpha4-subunit glycine receptor
        human GLRA1 protein
        human GLRA2 protein
        human GLRB protein
        mouse Glra1 protein
        mouse Glra2 protein
        mouse Glrb protein
        rat Glra1 protein
        rat Glra2 protein
        rat Glrb protein
        zebrafish glra1 protein
        Ligand-Gated Ion Channels: 221
        Cysteine Loop Ligand-Gated Ion Channel Receptors: 14
        Glycine Receptors: 484
        glycine receptor alpha3 subunit: 6
        strychnine receptor: 2
        alpha4-subunit glycine receptor
        human GLRA1 protein
        human GLRA2 protein
        human GLRB protein
        mouse Glra1 protein
        mouse Glra2 protein
        mouse Glrb protein
        rat Glra1 protein
        rat Glra2 protein
        rat Glrb protein
        zebrafish glra1 protein
  - Membrane Proteins: 10078

Experts

1.	Vincent, Angela: 19 articles (01/2020 - 08/2011)
2.	Harvey, Robert J: 16 articles (01/2022 - 07/2003)
3.	Lynch, Joseph W: 14 articles (01/2018 - 01/2006)
4.	Villmann, Carmen: 11 articles (01/2020 - 11/2009)
5.	Becker, Cord-Michael: 11 articles (01/2015 - 03/2002)
6.	Vincent, A: 9 articles (01/2021 - 10/2008)
7.	Waters, Patrick: 9 articles (01/2016 - 08/2011)
8.	Harvey, Kirsten: 7 articles (01/2022 - 07/2003)
9.	Zeilhofer, Hanns Ulrich: 7 articles (01/2022 - 05/2004)
10.	Xiong, Wei: 7 articles (01/2020 - 06/2012)

Related Diseases

1.	Hyperekplexia 07/15/2002 - "Hyperekplexia mutation of glycine receptors: decreased gating efficacy with altered binding thermodynamics." 01/07/2015 - "Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate disturbances in glycine receptor (GlyR) α1 biogenesis. " 01/01/2022 - "The genetic causes of the disease can vary, and several associated genes and mutations have been reported to affect glycine receptors (GlyRs); however, the mechanistic links between GlyRs and hyperekplexia are not yet understood. " 01/01/2022 - "Clinical, genetic, and functional characterization of the glycine receptor β-subunit A455P variant in a family affected by hyperekplexia syndrome." 04/01/2020 - "C.292G>A, a novel glycine receptor alpha 1 subunit gene (GLRA1) mutation found in a Chinese patient with hyperekplexia: A case report."
2.	Pain (Aches) 01/01/2023 - "Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. " 10/01/2020 - "Our data thus identified glycine receptor α1ins subunit as an important target for adenosinergic suppression of inflammatory pain." 01/01/2020 - "Glycine receptors (GlyRs) mediate fast inhibitory neurotransmission in the brain and have been recognized as key pharmacological targets for pain. " 11/09/2018 - "Glycine receptors (GlyRs) are involved in the development of spinal pain sensitization. " 01/01/2018 - "While recent work has identified clear deficits in fast GABAA- and glycine receptor-mediated inhibition in the adult spinal dorsal horn after neonatal tissue damage, the effects of early injury on slow, metabotropic inhibition within spinal pain circuits are poorly understood. "
3.	Epilepsy (Aura) 01/01/2017 - "Here, we show that miR-203 regulates glycine receptor-β (Glrb) in epilepsy models. " 10/19/2016 - "Glycine receptor antibody-associated epilepsy in a boy aged 4 years." 09/15/1995 - "Glycine receptor antagonists have been proposed to have multiple therapeutic applications, including the treatment of stroke, epilepsy, and anxiety. " 09/01/2003 - "In the present study, we investigated the amino acid concentrations as well as immunocytochemical and pharmacological properties of glycine-receptors in fresh human amygdala tissue obtained from epilepsy surgery. " 01/01/2021 - "Glycine receptor (GlyR) autoantibodies (Ab) have been recently detected in epilepsy patients. "
4.	Hyperalgesia 07/01/2009 - "Their anti-allodynia effects are mediated by the inhibition of GlyTs following activation of spinal glycine receptor alpha3. " 11/01/2004 - "The present data suggest that this allodynia could arise due to blockade of tonic GABAA and glycine-receptor mediated inhibition in the deep dorsal horn. " 11/01/2004 - "Intrathecal administration of both GABAA and glycine receptor antagonists has been shown elsewhere to induce tactile allodynia. " 07/01/1994 - "The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord." 02/01/2001 - "There is anatomic evidence for changes in these transmitter systems after nerve injuries, and blocking either GABAA or glycine receptors has been shown to produce allodynia-like behavior in awake normal animals. "
5.	Seizures (Absence Seizure) 12/01/2012 - "Since reduced function of glycine receptors causes seizures, we hypothesized that TXA and EACA inhibit the activity of glycine receptors. " 01/17/2003 - "These results indicate that Fe(2+) decreases I(tau) in acutely dissociated rat hippocampal neurons and the inhibition of glycine receptors by Fe(2+) might be one possible approach through which Fe(2+) induces seizures." 03/08/1991 - "The influence of strychnine-insensitive glycine receptor agonists and antagonists on generalized seizure thresholds." 01/01/2019 - "CPM-acid inhibits both GABAA and glycine receptors at the high (~100× clinical) plasma concentrations achieved during the dog studies, providing a plausible mechanism for the seizures." 11/28/2023 - "Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models."

Related Drugs and Biologics

1.	Strychnine
2.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
3.	Proteins (Proteins, Gene)
4.	Glycine (Aminoacetic Acid)
5.	gamma-Aminobutyric Acid (GABA)
6.	Serine (L-Serine)
7.	Taurine
8.	Baclofen
9.	Muscimol
10.	Ketamine

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Analgesia
4.	Immunotherapy
5.	Anesthesia