|1.||Sjölander, Anita: 9 articles (11/2015 - 10/2003)|
|2.||Gao, Yi: 5 articles (01/2015 - 05/2012)|
|3.||Mizutani, Nobuaki: 4 articles (11/2015 - 01/2003)|
|4.||Shi, Xu: 4 articles (01/2015 - 06/2013)|
|5.||Kanaoka, Yoshihide: 4 articles (12/2013 - 08/2007)|
|6.||Nabe, T: 4 articles (01/2009 - 06/2001)|
|7.||Kohno, S: 4 articles (01/2009 - 06/2001)|
|8.||Mizutani, N: 4 articles (01/2009 - 06/2001)|
|9.||Nabe, Takeshi: 3 articles (11/2015 - 08/2003)|
|10.||Zhu, Zheng: 3 articles (01/2015 - 06/2013)|
|1.||Asthma (Bronchial Asthma)
09/01/1988 - "L-648,051 is a potent receptor antagonist for leukotriene D4 and is potentially useful in the treatment of asthma and other allergic disorders. "
07/01/2003 - "Our identification of a second enzyme capable of cleaving LTD4 raises the possibility that clearance of LTD4 during asthma and in related inflammatory conditions may be mediated by more than one enzyme."
05/01/2012 - "The established procedure of LTD4 bronchial provocation test is effective in the diagnosis of asthma and is well tolerated. "
05/01/2014 - "Reperfusion of the rat kidney has been shown to up-regulate cysteinyl leukotriene-1 receptor, an asthma-associated gene in human bronchioles, and increase expression of leukotriene D4. "
12/01/2013 - "We investigated the positive threshold derived from the parameters and diagnostic power of IOS for asthma with the leukotriene D(4) bronchial provocation test. "
03/01/1994 - "These results show enhanced secretory function for LTD4 in animals with allergy to cow's milk. "
07/01/1986 - "In conclusion, LTD4 may play a role in nasal allergy by increasing blood flow and nasal airway resistance. "
06/01/1988 - "In conclusion, LTD4 plays an important role in nasal allergy presumably through long lasting and strong nasal blockage effects."
05/01/2014 - "Treatment with MK-571, a leukotriene D4 inhibitor, effectively attenuates airway hypersensitivity, pulmonary inflammatory response, and lung and kidney injury."
08/01/1989 - "The present study suggests that LTD4 is involved in conjunctival hypersensitivity reactions and that potent LTD4 receptor antagonists may be of therapeutic value in the treatment of allergic conjunctivitis."
12/15/1991 - "Detailed pharmacological intervention studies allow to conclude that endotoxin-induced leukotriene D4 release induces a transient ischemia by the known vasoconstrictive action of this eicosanoid. "
02/01/1985 - "These data suggest that LTD4 receptors are unevenly distributed in various vascular beds and that the splanchnic area is particularly vulnerable to anaphylaxis-induced ischemia. "
06/01/1991 - "Using the dorsal skinfold chamber model for intravital fluorescence microscopy of the microcirculation in striated muscle in awake hamsters and sequential RP-HPLC and RIA for leukotrienes, we demonstrate in this study that (a) the leukotrienes (LT)B4 and LTD4 elicit leukocyte/endothelium interaction and macromolecular leakage from postcapillary venules, respectively, that (b) leukotrienes accumulate in the tissue after ischemia and reperfusion, and that (c) selective inhibition of leukotriene biosynthesis (by MK-886) prevents both postischemic leukotriene accumulation and the microcirculatory changes after ischemia-reperfusion, while blocking of LTD4/E4 receptors (by MK-571) inhibits postischemic macromolecular leakage. "
06/01/1988 - "U46619 and LTD4 did induce transient, small reductions in regional shortening fraction during ischemia. "
04/01/1985 - "The capacity of verapamil to prevent LTD4-induced ischemia may be caused by higher residual CBF after LTD4 even though the magnitude of LTD4-induced CBF decrement was unaltered. "
|4.||Acute Kidney Injury (Acute Renal Failure)
04/01/1991 - "The LTD4 effects on the normal kidney were attenuated by simultaneous infusion of dopamine (5 microgram min-1 kg-1) or plasma expansion, two principal methods in the treatment of acute renal failure. "
05/01/2014 - "In this study, we aimed to investigate the efficacy of MK-571, a leukotriene D4 inhibitor, against hypersensitivity induced by kidney ischemia and reperfusion (I/R)-associated acute kidney injury. "
11/01/1991 - "The relative role of thromboxane (TxA2) and sulfidopeptide leukotrienes C4 (LTC4) and D4 (LTD4) in the acute renal failure induced by cyclosporine was studied in the rats. "
01/01/1985 - "Protective effects of a new LTD4 antagonist (LY-171883) in traumatic shock."
01/01/1985 - "The beneficial effect of LTD4 antagonism in the present study is consistent with the concept that peptide leukotrienes are important mediators of the pathogenesis of traumatic shock."
01/01/1985 - "We studied the effects of a selective antagonist of LTD4 (LY-171883, 2 and 4 mg/kg) in traumatic shock. "
10/01/1984 - "The increased survival time and reduced MDF activity afforded by these inhibitors suggest a significant role for lipoxygenase metabolites, particularly LTC4 and LTD4, in the pathogenesis of traumatic shock."
|6.||leukotriene D4 receptor (cysteinyl leukotriene receptor)
|8.||Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
|9.||Methacholine Chloride (Methacholine)
|5.||Heterologous Transplantation (Xenotransplantation)