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Leukotriene C4

The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Also Known As:
Leukotriene C; Leukotriene C-1; Leukotriene C-4; Leukotriene C1; Leukotrienes C; Leukotriene C 1; Leukotriene C 4; LTC4; Glycine, N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-N-L-gamma-glutamyl-L-cysteinyl)-, (R-(R*,S*-(E,E,Z,Z)))-
Networked: 871 relevant articles (21 outcomes, 83 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Kanaoka, Yoshihide: 9 articles (01/2021 - 10/2004)
2. Haeggström, Jesper Z: 7 articles (01/2016 - 07/2008)
3. Austen, K Frank: 6 articles (01/2021 - 10/2004)
4. Boyce, Joshua A: 6 articles (01/2021 - 01/2003)
5. Samuelsson, Bengt: 5 articles (01/2019 - 12/2010)
6. Park, Hae-Sim: 5 articles (11/2007 - 03/2004)
7. Barrett, Nora A: 4 articles (01/2021 - 04/2006)
8. Feng, Chunli: 4 articles (01/2021 - 12/2013)
9. Lai, Juying: 4 articles (01/2021 - 06/2015)
10. Liu, Tao: 4 articles (01/2021 - 12/2013)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Anaphylaxis (Anaphylactic Shock)
3. Reperfusion Injury
4. Pulmonary Edema
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Leukotriene B4
2. Leukotriene D4
3. Histamine (Histamine Dihydrochloride)
4. Dinoprostone (PGE2)
5. Leukotrienes
6. Leukotriene E4
7. Albumins
8. Prostaglandin D2
9. Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
10. Lipoxygenase Inhibitors

Related Therapies and Procedures

1. Therapeutics
2. Intravenous Administration
3. Ligation
4. Contact Lenses
5. Intra-Arterial Infusions