Azithromycin (Zithromax)

A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

Also Known As:

Zithromax; Azadose; Azithromycin Dihydrate; Azithromycin Monohydrate; Azitrocin; Azythromycin; CP-62993; Goxal; Sumamed; Toraseptol; Ultreon; Vinzam; Zentavion; Zitromax; CP 62993; CP62993; Dihydrate, Azithromycin; Monohydrate, Azithromycin; 1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-, (2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*))-

Networked: 5069 relevant articles (847 outcomes, 1092 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Erythromycin: 3910
        Azithromycin: 5069
        CSY 0073: 2
        9a-N-desmethylazithromycin
        N-desmethylazithromycin

Experts

1.	Lietman, Thomas M: 81 articles (10/2022 - 02/2003)
2.	West, Sheila K: 57 articles (10/2022 - 04/2003)
3.	Porco, Travis C: 54 articles (10/2022 - 03/2009)
4.	Keenan, Jeremy D: 51 articles (10/2022 - 03/2009)
5.	Bailey, Robin L: 39 articles (02/2022 - 11/2004)
6.	Solomon, Anthony W: 37 articles (11/2021 - 04/2003)
7.	Munoz, Beatriz: 36 articles (01/2021 - 01/2003)
8.	Oldenburg, Catherine E: 33 articles (10/2022 - 01/2018)
9.	Gaynor, Bruce D: 31 articles (01/2019 - 11/2004)
10.	Zhou, Zhaoxia: 27 articles (10/2022 - 11/2004)

Related Diseases

1.	Infections 01/01/2011 - "it is known that the efficacy of azithromycin, in animal infection models, is best correlated with AUC/MIC. " 09/01/2003 - "These results suggest that azithromycin is effective in the prophylaxis and early infection of a highly virulent strain of T. " 04/01/2016 - "The infection was detected and the 2 patients had good outcomes following azithromycin treatment. " 05/01/1997 - "We conclude that the long half-life of azithromycin which is beneficial in treating chlamydial infection may result in increased selective pressure for resistance in gonococci. " 09/01/1996 - "Azithromycin is one possibility, as it has been shown to be effective for chlamydial infection in numerous studies, and has been found satisfactory for gonorrhoea where local isolates were susceptible. "
2.	COVID-19 01/01/2021 - "We describe three patients diagnosed with COVID-19 who did not respond to the initial treatment but improved dramatically upon adding azithromycin with a successful outcome. " 01/01/2021 - "So significant research priority is needed to determine whether azithromycin is useful in the treatment of COVID-19." 10/01/2021 - "Azithromycin did not result in a superior clinical improvement in COVID-19 patients, although it was well-tolerated and safe to use." 10/01/2021 - "We assessed whether azithromycin is effective in reducing hospital admission in patients with mild-to-moderate COVID-19. " 01/01/2022 - "The initial screening revealed that azithromycin (AZM) might have potential against COVID-19. "
3.	Pneumonia (Pneumonitis) 01/01/2003 - "Azithromycin proved to be effective cure for environmental pneumonia. " 10/01/1991 - "Side effects were observed in one patient in Group I and in one patient in Group II. The results suggest that a 1.5 g total dose of azithromycin is equally effective when administered as a three- or five-day regimen for the treatment of atypical pneumonia." 03/01/1995 - "This study was designed to evaluate the efficacy of a 3 day course of azithromycin in low to moderately severe community-acquired pneumonia. " 08/01/2022 - "With a 14-day course of azithromycin and prompt initiation of dialysis, the patient's pneumonia and systemic sequelae improved. " 01/01/2019 - "Efficacy of Azithromycin in a Mouse Pneumonia Model against Hospital-Acquired Methicillin-Resistant Staphylococcus aureus."
4.	Trachoma 03/01/2014 - "Mass oral azithromycin distributions have dramatically reduced the prevalence of the ocular strains of chlamydia that cause trachoma. " 11/01/2004 - "Azithromycin is highly effective against trachoma, but the practical difficulties of community-wide distribution often leave many individuals untreated. " 01/01/2018 - "Repeated oral azithromycin distribution targeted only to children has proven effective in reducing the ocular Chlamydia that causes trachoma. " 01/01/2019 - "The lack of resistance in Chlamydia trachomatis suggests that azithromycin might remain effective for trachoma programmes, but evidence is scarce. " 03/02/2012 - "Mass treatment with azithromycin to control trachoma can be considered cost effective in the African but not the South East Asian sub-region. "
5.	Cystic Fibrosis (Mucoviscidosis) 09/01/2009 - "Although long-term use of azithromycin has shown a significant clinical improvement for patients with cystic fibrosis (CF), its long-term effect on the susceptibility of commensal flora within CF airways has not yet been examined. " 11/01/2004 - "The evidence for the clinical benefit of azithromycin in cystic fibrosis has been summarized in a Cochrane review in which a meta-analysis confirmed a significant improvement in forced expiratory volume in 1 second among the 286 pooled participants. " 11/01/2007 - "Azithromycin has antiinflammatory properties and is effective in cystic fibrosis (CF) patients. " 10/15/2005 - "We recently reported a randomized, placebo-controlled trial of azithromycin in patients with cystic fibrosis (CF) that demonstrated a 6.2% improvement in the 168-d relative change in FEV1 among azithromycin participants compared with placebo participants. " 01/01/2020 - "Rationale: Chronic azithromycin is commonly used in cystic fibrosis based on short controlled clinical trials showing reductions in pulmonary exacerbations and improved FEV1. "

Related Drugs and Biologics

1.	Doxycycline (Periostat)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Clarithromycin (Biaxin)
4.	Macrolides
5.	Hydroxychloroquine (Plaquenil)
6.	Erythromycin (Erycette)
7.	Ceftriaxone (Ceftriaxon)
8.	Amoxicillin (Wymox)
9.	Ciprofloxacin (Cipro)
10.	Ophthalmic Solutions (Eye Drops)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Root Planing

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