|1.||Karmazyn, Morris: 9 articles (12/2014 - 04/2002)|
|2.||Fliegel, Larry: 9 articles (09/2012 - 03/2007)|
|3.||Mraiche, Fatima: 7 articles (06/2015 - 05/2007)|
|4.||Wu, Dongmei: 7 articles (08/2014 - 06/2009)|
|5.||McDonough, Alicia A: 7 articles (07/2012 - 11/2002)|
|6.||Cingolani, Horacio E: 6 articles (05/2015 - 03/2002)|
|7.||Casavola, Valeria: 6 articles (02/2015 - 10/2005)|
|8.||Reshkin, Stephan J: 6 articles (11/2013 - 10/2005)|
|9.||Gazmuri, Raúl J: 6 articles (02/2011 - 04/2002)|
|10.||Ayoub, Iyad M: 6 articles (02/2011 - 04/2002)|
11/01/2003 - "By 30 minutes of reperfusion, regional end-systolic pressure-dimension relation decreased further in the ischemia and reperfusion-only group (1.6 +/- 0.2, P <.05), but improved with Na(+)/H(+) exchanger inhibition (4.4 +/- 0.7, P <.05). "
02/01/2009 - "Sarcolemmal Na(+)/H(+) exchanger (NHE) activity, which is provided by the NHE isoform 1 (NHE1), has been implicated in ischemia/reperfusion-induced myocardial injury in animal models and humans, on the basis of studies with pharmacological NHE1 inhibitors. "
04/15/2015 - "Ischemic preconditioning inhibits expression of Na(+)/H(+) exchanger 1 (NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia."
01/05/2013 - "Following ischemia, a cascade of deleterious events including over-activity of Na(+)-H(+) Exchanger (NHE) takes place. "
01/01/2012 - "A higher increase in intracellular Na(+) via Na(+)/H(+) exchanger (NHE) during ischemia has been reported in type 2 diabetic mouse hearts. "
04/01/2008 - "The findings suggest that sodium hydrogen exchanger isoform-1 inhibition holds promise for a new class of drugs that could significantly reduce myocardial injury associated with ischemia-reperfusion injury."
01/01/2014 - "Activation of the Na(+)/H(+) exchanger (NHE) at the time of reperfusion plays an important role in ischemia-reperfusion injury. "
11/01/2011 - "On the other hand, Na(+)/H(+) exchanger (NHE)-1 inhibitor has been demonstrated to exert beneficial effects in ischemic-reperfusion injury and in the development of cardiac remodeling. "
07/01/2010 - "Current strategies to ameliorate cardiac ischaemic and reperfusion damage, including block of the sodium-hydrogen exchanger, are therapeutically ineffective. "
02/01/2008 - "Selective inhibition of Na(+)/H(+) exchanger (NHE) improves organ dysfunctions including heart ischemia-reperfusion injury. "
04/01/2002 - "Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1."
05/19/2000 - "Inhibition of the Na(+)/H(+) exchanger attenuates phase 1b ischemic arrhythmias and reperfusion-induced ventricular fibrillation."
12/01/2015 - "The Na(+)/H(+) exchanger inhibitor EIPA attenuated the electrophysiological effects responsible for the acceleration and increased complexity of ventricular fibrillation induced by acute myocardial stretch. "
10/01/2007 - "To investigate whether sodium-hydrogen exchanger isoform-1 (NHE-1) inhibition attenuates myocardial injury during resuscitation from ventricular fibrillation through effects on energy metabolism, using an open-chest pig model in which coronary perfusion was controlled by extracorporeal circulation. "
04/01/2009 - "We now investigated the role of caspase-3 activation by examining whether such process prompts apoptotic DNA fragmentation, whether caspase-3 inhibition attenuates myocardial dysfunction, and whether myocardial protective effects of sodium-hydrogen exchanger isoform-1 (NHE-1) inhibition involve caspase-3 inhibition using a rat model of ventricular fibrillation (VF) of closed-chest resuscitation. "
10/01/1996 - "These studies demonstrate that the increase in Na/H antiporter activity seen in metabolic acidosis involves an increase in NHE3 protein abundance, which is distributed along the proximal tubule and the thick ascending limb. "
01/01/2013 - "We hypothesized that targeting pH-regulatory protein, Na(+)/H(+) exchanger (NHE1) could be a novel approach for the treatment of acute metabolic acidosis. "
11/01/2010 - "In conclusion, the neonatal proximal tubule can adapt to metabolic acidosis with an increase in Na(+)/H(+) exchanger activity."
11/01/2010 - "Proximal convoluted tubule Na(+)/H(+) exchanger activity (dpH(i)/dt) was 1.68 ± 0.19 pH units/min in control tubules and 2.49 ± 0.60 pH units/min in acidemic neonatal mice (P < 0.05), indicating that the neonatal proximal tubule can respond to metabolic acidosis with an increase in Na(+)/H(+) exchanger activity. "
07/01/2010 - "The Na(+)/H(+) exchanger (NHE-1) plays a key role in pH(i) recovery from acidosis and is regulated by pH(i) and the ERK1/2-dependent phosphorylation pathway. "
04/19/2002 - "In this study, we have identified the cardiac Na(+)-H(+) exchanger (NHE1) as a novel mediator of adrenergically induced heart failure. "
12/01/2014 - "Na(+)/H(+) exchanger 1 (NHE-1) inhibition attenuates the hypertrophic response and heart failure in various experimental models. "
11/01/2006 - "At all stimulation frequencies, Na(+)/H(+) exchanger inhibition reduced pH(i) by 0.05 pH units (P < or = 0.01) and contractility by 22% (P < or = 0.05) in cardiomyocytes from the heart failure group. "
01/01/2005 - "Less Na+/H+-exchanger to treat heart failure: a simple solution for a complex problem?"
10/10/2008 - "Activation of the sarcolemmal Na(+)/H(+) exchanger (NHE)1 is increasingly documented as a process involved in cardiac hypertrophy and heart failure. "
|5.||(1- (quinolin- 5- yl)- 5- cyclopropyl- 1H- pyrazole- 4- carbonyl)guanidine
|6.||Caspase 3 (Caspase-3)
|8.||Glutamate-Ammonia Ligase (Glutamine Synthetase)
|2.||Cardiopulmonary Bypass (Heart-Lung Bypass)
|3.||Deep Hypothermia Induced Circulatory Arrest
|5.||Coronary Artery Bypass (Coronary Artery Bypass Surgery)