|1.||Anderson, Mark E: 20 articles (01/2016 - 09/2002)|
|2.||Maier, Lars S: 9 articles (12/2014 - 12/2006)|
|3.||Luczak, Elizabeth D: 8 articles (02/2014 - 03/2010)|
|4.||Mattiazzi, Alicia: 7 articles (01/2016 - 01/2002)|
|5.||Mohler, Peter J: 7 articles (07/2013 - 09/2007)|
|6.||Bers, Donald M: 6 articles (05/2015 - 12/2006)|
|7.||Wehrens, Xander H T: 6 articles (09/2014 - 07/2009)|
|8.||Valverde, Carlos A: 5 articles (01/2016 - 06/2010)|
|9.||Sossalla, Samuel: 5 articles (12/2014 - 10/2010)|
|10.||Grumbach, Isabella M: 5 articles (02/2014 - 02/2010)|
10/29/2010 - "Heart failure (HF) is known to be associated with increased Ca(2+)/calmodulin-dependent protein kinase (CaMK)II expression and activity. "
03/17/2000 - "Sarcoplasmic reticulum Ca(2+)/Calmodulin-dependent protein kinase is altered in heart failure."
08/01/2010 - "Cardiac Ca(2+)/calmodulin-dependent protein kinase (CaMK) IIdelta expression and activity are altered in cardiac hypertrophy and heart failure. "
04/11/2014 - "Although the RyR is involved in heart failure-related Ca(2+) disturbances, this results from Ca(2+)-calmodulin kinase II and reactive oxygen species-mediated regulation rather than by RyR2808 phosphorylation. "
03/15/2014 - "Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) hyperactivity in heart failure causes intracellular Na(+) ([Na(+)]i) loading (at least in part by enhancing the late Na(+) current). "
05/01/1995 - "Ca2+/calmodulin kinase II translocates in a hippocampal slice model of ischemia."
09/01/2007 - "Mice with genetic inhibition (AC3-I) of the multifunctional Ca(2+)/calmodulin dependent protein kinase II (CaMKII) have improved cardiomyocyte survival after ischemia. "
11/01/2015 - "Live imaging of endogenous Ca(2+) /calmodulin-dependent protein kinase II in neurons reveals that ischemia-related aggregation does not require kinase activity."
09/01/2014 - "Ca(2+)-calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia/reperfusion (I/R). "
03/01/2014 - "While Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) has been suggested to be an important protein regulating heart function upon ischemia/reperfusion (I/R), the mechanisms responsible are not fully known. "
|3.||Heart Diseases (Heart Disease)
12/01/2005 - "Calmodulin kinase II as a target for inhibition in cardiac disease."
04/01/2005 - "Calmodulin kinase II inhibition protects against structural heart disease."
06/01/2012 - "The objective of this study was to establish whether 1) hyperactivity of renin-angiotensin-aldosterone system (RAAS) produces apoptosis in early stages of cardiac disease; and 2) Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is involved in these apoptotic events. "
01/01/2016 - "Although multifunctional Ca(2+) calmodulin-dependent protein kinase II (CaMKII) is ROS-activated and CaMKII hyperactivity promotes cardiac diseases, a link between prediabetes and CaMKII in the heart is unprecedented. "
01/01/2013 - "This review evaluates recent advances in mechanisms underlying aldosterone-induced cardiac disease and highlights the interplay between aldosterone and Ca(2+)/calmodulin dependent protein kinase II, whose hyperactivity during heart failure contributes to disease progression. "
|4.||Body Weight (Weight, Body)
09/01/2010 - "Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. "
08/08/2008 - "Previously we showed that following hypoxia there is an increase in nuclear Ca(2+)-influx and Ca(2+)/calmodulin-dependent protein kinase IV activity (CaMK IV) in the cerebral cortex of term guinea pig fetus. "
03/15/2004 - "The induction of TPI gene expression by hypoxia was suppressed by (1) a chelator of intracellular Ca(2+), (2) a blocker of non-selective cation channels, (3) a blocker of Na(+)/Ca(2+) exchangers, (4) an inhibitor of Ca(2+)/calmodulin-dependent protein kinases, and (5) an inhibitor of c-jun/AP-1 activation."
11/01/1999 - "To study the effect of dopamine receptor antagonists on anoxia-induced inhibition of Ca(2+)-calmodulin dependent protein kinase II (CCDPK II) activity in rat hippocampus and striatum. "
11/01/2014 - "Moreover, when the levels of [Ca(2+)]i were increased by hypoxia, H-89, but not KN93, (a calmodulin kinase II inhibitor), prevented the reduction in [Ca(2+)]i by TNFα. "
01/01/2014 - "Previously, we have demonstrated in the newborn piglet that within one hour of exposure to hypoxia, there is increased activation of the enzyme Ca++/calmodulin kinase (CaM Kinase) IV localized in the nucleus, a key regulator of transcription of apoptotic genes. "
|1.||Calcium-Calmodulin-Dependent Protein Kinase Type 2
|4.||Protein Kinases (Protein Kinase)
|5.||Protein Kinase C
|6.||Mitogen-Activated Protein Kinase 3
|7.||Messenger RNA (mRNA)
|8.||Brain-Derived Neurotrophic Factor (BDNF)
|9.||protein kinase D
|10.||G-Protein-Coupled Receptor Kinase 2
|2.||Implantable Defibrillators (Implantable Cardioverter-Defibrillator)