Calcium-Calmodulin-Dependent Protein Kinases

A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)

Also Known As:

Calcium-Calmodulin-Dependent Protein Kinases, Multifunctional; Calcium-Calmodulin-Dependent Protein Kinases, Restricted; Calmodulin-Dependent Multiprotein Kinase; Calmodulin-Kinase; Cam-MPK; Multifunctional Calcium-Calmodulin-Dependent Protein Kinases; Restricted Calcium-Calmodulin-Dependent Protein Kinases; Calcium Calmodulin Dependent Protein Kinase; Calcium Calmodulin Dependent Protein Kinases, Multifunctional; Calcium Calmodulin Dependent Protein Kinases, Restricted; Calmodulin Dependent Multiprotein Kinase; Calmodulin Dependent Protein Kinase; Calmodulin Dependent Protein Kinases; Calmodulin Kinase; Cam MPK; Kinase, Calcium-Calmodulin-Dependent Protein; Kinase, Calmodulin-Dependent Protein; Multifunctional Calcium Calmodulin Dependent Protein Kinase; Multifunctional Calcium Calmodulin Dependent Protein Kinases; Multiprotein Kinase, Calmodulin-Dependent; Protein Kinase, Calcium-Calmodulin-Dependent; Protein Kinase, Calmodulin-Dependent; Protein Kinases, Calcium-Calmodulin-Dependent; Protein Kinases, Calmodulin-Dependent; Restricted Calcium Calmodulin Dependent Protein Kinase; Restricted Calcium Calmodulin Dependent Protein Kinases; Ca(2+)-Calmodulin-Dependent Protein Kinase; Calcium-Calmodulin-Dependent Protein Kinase; Calmodulin-Dependent Protein Kinase; Calmodulin-Dependent Protein Kinases; Multifunctional Calcium-Calmodulin-Dependent Protein Kinase; Restricted Calcium-Calmodulin-Dependent Protein Kinase

Networked: 658 relevant articles (13 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Anderson, Mark E: 24 articles (01/2020 - 01/2002)
2.	Maier, Lars S: 17 articles (08/2017 - 12/2006)
3.	Bers, Donald M: 14 articles (12/2021 - 12/2005)
4.	Luczak, Elizabeth D: 9 articles (01/2020 - 03/2010)
5.	Mohler, Peter J: 9 articles (01/2020 - 09/2007)
6.	Wehrens, Xander H T: 9 articles (01/2020 - 07/2009)
7.	Hasenfuss, Gerd: 9 articles (01/2019 - 12/2006)
8.	Mattiazzi, Alicia: 9 articles (01/2019 - 01/2002)
9.	Sossalla, Samuel: 8 articles (10/2020 - 09/2010)
10.	Backs, Johannes: 8 articles (05/2017 - 11/2009)

Related Diseases

1.	Obesity 12/03/2013 - "Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling." 12/20/2017 - "Activation of calmodulin dependent protein kinase (CaMK)II by exercise is beneficial in controlling membrane lipids associated with type 2 diabetes and obesity. " 03/01/2021 - "Calmodulin-dependent protein kinase activation by exercise is helpful in controlling membrane lipids related with type 2 diabetes and obesity. " 11/20/2020 - "Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) regulates several key physiological and pathophysiological processes, and its dysregulation has been implicated in obesity, diabetes, and cancer. " 01/01/2017 - "Additionally, obesity-activated calcium/calmodulin dependent-protein kinase II/p38 suppresses insulin-induced protein kinase B phosphorylation by activating the ER stress effector, activating transcription factor-4. "
2.	Type 2 Diabetes Mellitus (MODY) 11/01/2014 - "Cutaneous expression of calcium/calmodulin-dependent protein kinase II in rats with type 1 and type 2 diabetes." 09/05/2014 - "The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes." 03/01/2013 - "Expression of calcium/calmodulin-dependent protein kinase II and pain-related behavior in rat models of type 1 and type 2 diabetes." 01/01/2023 - "Here we show that calcium/calmodulin-dependent protein kinase ID (CaMK1D), a genetic hot spot in type 2 diabetes, is activated upon ghrelin stimulation and acts in AgRP/NPY neurons to mediate ghrelin-dependent food intake. " 12/20/2017 - "Activation of calmodulin dependent protein kinase (CaMK)II by exercise is beneficial in controlling membrane lipids associated with type 2 diabetes and obesity. "
3.	Body Weight (Weight, Body) 10/28/2011 - "The protein analysis in the neonatal brain showed changes in the levels of calcium/calmodulin-dependent protein kinase II (CaMKII), growth associated protein-43 (GAP-43) and synaptophysin following neonatal exposure to PBDE 99 (21 μmol/kg body weight), but not following exposure TBBPA. " 09/01/2010 - "Comparing with young and aged unimpaired animals, aged impaired rats exhibited significant reduction in hippocampal but not cortical cAMP-response element-binding phosphorylation states as well as brain-derived neurotrophic factor messenger RNA and protein expressions, which were accompanied by decreased phosphorylation states of hippocampal extracellular signal-related kinase (42/44) and calcium calmodulin kinase IV. Lotus seedpod supplementation (50 and 100 mg/kg body weight intragastric administration) for 7 weeks significantly reversed all these declines happened in hippocampus except calcium calmodulin kinase IV phosphorylation levels. " 10/12/2017 - "We herein demonstrated that (1) HMF was detectable in the brain 10 and 30 min after its oral administration, (2) orally administered HMF improved chronic unpredictable mild stress (CUMS)-induced pathological conditions, including body weight loss and depressive-like behavior, and CUMS-induced neurochemical changes, such as reduction in BDNF expression, decrease in neurogenesis, and decreased level of phosphorylated calcium-calmodulin-dependent protein kinase II in the hippocampus, and (3) these effects of HMF were inhibited by the pre-administration of U0126, a mitogen-activated protein (MAP) kinase inhibitor. "
4.	Ischemia 02/01/1994 - "The purpose of this study was to delineate the course of these changes after focal ischemia and to clarify the relation of changes in activity of calcium/calmodulin-dependent protein kinase II to the process of ischemic cell death. " 09/01/2016 - "Objective To evaluate the impact of miR-148a on hepatic ischemia/reperfusion (I/R) injury via inhibiting Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα), and analyze the potential mechanism. " 10/01/2013 - "We previously demonstrated that calmodulin-dependent protein kinase IIα (CaM-KIIα) phosphorylates nNOS at Ser(847) in the hippocampus after forebrain ischemia; this phosphorylation attenuates NOS activity and might contribute to resistance to post-ischemic damage. " 06/01/2002 - "Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain." 02/01/1996 - "Autophosphorylation as a possible mechanism of calcium/calmodulin-dependent protein kinase II inhibition during ischemia."
5.	Cardiomegaly (Heart Hypertrophy) 01/01/2007 - "[The effects of calmodulin kinase II inhibitor on ventricular arrhythmias in rabbits with cardiac hypertrophy]." 01/01/2002 - "Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy." 05/01/2000 - "Here, we show that activated Ca(2+)/calmodulin-dependent protein kinases-I and -IV (CaMKI and CaMKIV) also induce hypertrophic responses in cardiomyocytes in vitro and that CaMKIV overexpressing mice develop cardiac hypertrophy with increased left ventricular end-diastolic diameter and decreased fractional shortening. " 08/01/2010 - "Cardiac Ca(2+)/calmodulin-dependent protein kinase (CaMK) IIdelta expression and activity are altered in cardiac hypertrophy and heart failure. " 09/15/2015 - "The present study aimed to test the hypothesis that SK channel activity is increased via the Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-dependent pathway in hypertensive cardiac hypertrophy. "

Related Drugs and Biologics

1.	Calcium-Calmodulin-Dependent Protein Kinase Type 2
2.	Proteins (Proteins, Gene)
3.	Brain-Derived Neurotrophic Factor (BDNF)
4.	Calcium
5.	Phosphotransferases (Kinase)
6.	Membrane Lipids
7.	Protein Kinases (Protein Kinase)
8.	Protein Kinase C
9.	Protein Isoforms (Isoforms)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Oral Administration
2.	Electroacupuncture
3.	Microspheres (Microsphere)
4.	Cardiopulmonary Bypass (Heart-Lung Bypass)
5.	Catheters