|1.||Stratakis, Constantine A: 41 articles (06/2015 - 06/2002)|
|2.||Kirschner, Lawrence S: 16 articles (05/2014 - 06/2002)|
|3.||Nesterova, Maria: 12 articles (09/2014 - 06/2002)|
|4.||Stratakis, C A: 10 articles (11/2014 - 05/2001)|
|5.||Bertherat, Jérôme: 10 articles (03/2014 - 12/2002)|
|6.||Cho-Chung, Yoon S: 10 articles (09/2006 - 02/2002)|
|7.||Groussin, Lionel: 9 articles (01/2011 - 12/2002)|
|8.||Levine, J D: 8 articles (10/2012 - 01/2001)|
|9.||Levine, Jon D: 7 articles (09/2015 - 10/2002)|
|10.||Ragazzon, Bruno: 7 articles (03/2014 - 10/2008)|
09/01/2012 - "Since protein kinase A (PKA) is a central key component of the cAMP pathway, studies of the alterations of PKA subunits in endocrine tumors reveal new aspects of the mechanisms of cAMP pathway alterations in human diseases. "
04/01/2007 - "The present study was designed to characterize the population distribution of extracellular activity of cAMP-dependent protein kinase (ECPKA) and its potential value as a biomarker for cancer detection and monitoring of cancer therapy. "
01/01/1996 - "These cells were used to study if phosphorylation reactions by protein kinase A (PKA) and dephosphorylation reactions by protein phosphatases-1 and -2A (PP-1/2A) regulate tumor motility and adhesion to extracellular matrix components, and if this might be associated with cytoskeletal reorganization. "
10/01/1988 - "The results of this study indicate that TPA induces morphological changes in the Y-1 adrenocortical tumor cell population while increasing steroidogenesis and the activation of cAMP-dependent protein kinase and decreasing cell growth rate."
05/15/1987 - "No such microheterogeneity was noted for isozyme I. This study thus shows that the lack of cAMP-responsiveness of one tumor is related either to a defect distal to the cAMP-dependent protein kinases or to the appearance of the new subtype of RII in the resistant tumor. "
04/01/2010 - "Because cAMP signaling has been implicated in regulating diverse developmental and infection processes in fungal pathogens, in this study, we aimed to elucidate the function of the cAMP-protein kinase A (PKA) pathway in toxin production and plant infection in F. "
12/01/2011 - "The cyclic AMP-dependent protein kinase A signaling pathway plays a major role in regulating plant infection by the rice blast fungus Magnaporthe oryzae. "
07/01/2010 - "Protein kinase A phosphorylation activates Vpr-induced cell cycle arrest during human immunodeficiency virus type 1 infection."
01/01/2010 - "The gene fpk1, encoding a cAMP-dependent protein kinase catalytic subunit homolog, is required for hyphal growth, spore germination, and plant infection in Fusarium verticillioides."
12/01/2008 - "The phosphorylation profile of protein kinase A substrates is modulated during Varicella-zoster virus infection."
|3.||Memory Disorders (Memory Loss)
01/01/2012 - "However, mechanistic links between protein kinase A (PKA), oxidative stress and memory loss in response to Aβ remain elusive. "
03/01/2005 - "cAMP-dependent protein kinase A (PKA) signaling has a key role in memory processes and has been identified as a potential therapeutic target for memory disorders. "
03/01/2005 - "Protein kinase A as a therapeutic target for memory disorders: rationale and challenges."
05/01/1986 - "The findings suggest that in the mutant's nerve cells the state of phosphorylation of the regulatory subunit of cAMP-dependent protein kinase is altered, which may contribute to the biochemical disorder leading to the memory deficit."
01/01/2015 - "Escitalopram Ameliorates Tau Hyperphosphorylation and Spatial Memory Deficits Induced by Protein Kinase A Activation in Sprague Dawley Rats."
08/10/2012 - "We also show that mutation of the phosphorylation site for cAMP-dependent protein kinase on DARPP-32 attenuates l-DOPA-induced dyskinesia and reduces the concomitant activations of ERK and mTORC1 signaling. "
03/01/2012 - "Chronic Levodopa (L-DOPA), the gold standard therapy for Parkinson's disease (PD), causes disabling motor complications (dyskinesias) that are associated with changes in the activity of striatal protein kinase A (PKA) and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32). "
01/15/2015 - "Previous studies have implicated the cyclic adenosine monophosphate/protein kinase A pathway as well as FosB and dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3,4-dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesia. "
01/01/2010 - "In rodents, the development of dyskinesia produced by L-DOPA in the dopamine-depleted striatum occurs in response to increased dopamine D1 receptor-mediated activation of the cAMP - protein kinase A and of the Ras-extracellular signal-regulated kinase (ERK) signalling pathways. "
|5.||Cardiac Arrhythmias (Arrythmia)
10/01/1997 - "Drosophila melanogaster deficient in protein kinase A manifests behavior-specific arrhythmia but normal clock function."
10/23/2012 - "Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases."
10/12/2007 - "Increased phosphorylation of the cardiac ryanodine receptor (RyR)2 by protein kinase A (PKA) at the phosphoepitope encompassing Ser2808 has been advanced as a central mechanism in the pathogenesis of cardiac arrhythmias and heart failure. "
06/23/2006 - "It is suggested that protein kinase A (PKA)-dependent phosphorylation of cardiac ryanodine receptors (RyR2) is linked to the development of heart failure and the generation of fatal cardiac arrhythmias. "
01/01/2006 - "Protein kinase A (PKA) hyperphosphorylation of RyR2 in failing hearts or mutations in RyR2 linked to sudden cardiac death (SCD) can result in diastolic sarcoplasmic reticulum (SR) Ca2+ leak that can trigger fatal cardiac arrhythmias, and deplete SR Ca2+ stores contributing to decreased contractility. "
|1.||Adenosine Monophosphate (AMP)
|2.||Protein Kinases (Protein Kinase)
|5.||Levodopa (L Dopa)
|8.||Type I DNA Topoisomerases (Topoisomerase I)
|9.||protein kinase modulator
|1.||Heterologous Transplantation (Xenotransplantation)