Artificial Skin

Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.

Also Known As:

Networked: 984 relevant articles (74 outcomes, 90 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Boyce, Steven T: 35 articles (01/2021 - 02/2002)
2.	Supp, Dorothy M: 21 articles (01/2020 - 06/2002)
3.	Reichmann, Ernst: 12 articles (01/2022 - 06/2010)
4.	Germain, Lucie: 11 articles (05/2022 - 06/2002)
5.	Biedermann, Thomas: 11 articles (01/2022 - 06/2010)
6.	Larouche, Danielle: 9 articles (05/2022 - 06/2002)
7.	Auger, François A: 9 articles (01/2021 - 06/2002)
8.	Jeschke, Marc G: 8 articles (01/2019 - 01/2004)
9.	Bayat, Ardeshir: 8 articles (01/2018 - 01/2012)
10.	Meuli, Martin: 7 articles (01/2019 - 03/2013)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2006 - "Artificial skin substitutes are beneficial in the treatment of chronic wounds although their performance relative to authentic human skin is unclear. " 05/01/2023 - "There is a demonstrable need for quality measures that encourage (1) frequent and adequate debridement throughout wound treatment, (2) earlier adoption of advanced treatments, such as skin substitutes, for LEDUs to align with clinical guidelines, (3) the application of skin substitutes to better align with medical evidence, which is associated with improved patient outcomes, as well as (4) expansion of best practices across all demographic and socioeconomic populations." 10/01/2023 - "This work advances the functional properties of tissue engineered skin and holds promise for improving the therapeutic efficacy of artificial skin grafts for the skin wounds." 04/01/2014 - "Increased wound chronicity has promulgated the use of advanced wound care products, including Living Skin Substitutes (LSS), in an attempt to obtain wound closure, and ultimately both physiological and functional healing.(1-3) In the outpatient setting, it is evident that the efficacy of the LSS varies widely depending on the patient type with some patients responding quite favorably while others who do not achieve healing despite repeated applications of LSS. " 07/01/2008 - "Tissue-engineered cultured skin substitutes (CSS) are used to aid wound closure in massively burned patients, and have been used to facilitate safe and effective wound closure in adult patients with chronic wounds. "
2.	Burns 10/01/2012 - "Engineered skin substitutes (ESS) have been used successfully to treat life-threatening burns, but lack cutaneous appendages. " 08/01/2004 - "The clinical use of an artificial skin substitute (Integra) has been celebrated enthusiastically as an improvement in burn therapy over a period of more than 10 years. " 09/09/2021 - "Certain limitations exist in the development of technologies to rapidly prepare skin substitutes that are therapeutically effective in surgeries involving extensive burns and skin transplantation. " 01/01/1990 - "Artificial skin (Integra) has been developed as an effective treatment of full-thickness burns. " 09/30/2023 - "As a promising treatment for third-degree burns, grafting with bioengineering skin substitutes shows a capability to overcome the deficiency of donor skin. "
3.	Ulcer 09/01/2013 - "This retrospective study evaluates the safety and efficacy of an autologous, dermal-epidermal skin substitute (SS) for treating ulcers of various origins. " 03/01/2007 - "Letter: efficacy of a self-made artificial skin in the treatment of chronic ulcers." 12/01/2015 - "A prospective, randomised, controlled, multi-centre comparative effectiveness study of healing using dehydrated human amnion/chorion membrane allograft, bioengineered skin substitute or standard of care for treatment of chronic lower extremity diabetic ulcers." 04/18/2007 - "The trials comparing bilayer artificial skin with a dressing reported a significantly higher proportion of ulcers healing with artificial skin. " 01/25/2005 - "The trials comparing bilayer artificial skin with a dressing reported a significantly higher proportion of ulcers healing with artificial skin. "
4.	Cicatrix (Scar) 01/01/2021 - "Inclusion of topical negative pressure, dermal regenerative templates, acellular dermal matrices, and noncellular skin substitutes in management has helped improve scar and functional outcomes. " 11/01/2022 - "The generation of appendage-bearing skin substitutes can be applied in practice for wound healing, hair restoration, and scar treatment." 09/30/2022 - "Faster wound healing time, scar formation and length of hospitalization were identified as heterogeneous depending on the type of skin substitutes used. " 07/30/2021 - "Yet, despite extensive research on impaired wound healing and the advancement in tissue-engineered skin substitutes, scar formation remains a significant clinical challenge. " 01/01/2019 - "Special attention is given to the properties of skin substitutes in terms of cell composition and the ability to prevent scarring."
5.	Diabetic Foot 03/01/2017 - "The aim of this study was to obtain autologous dermal-epidermal skin substitutes from oral mucosa from diabetic subjects as a first step towards a possible clinical application for cases of diabetic foot. " 01/01/2018 - "Randomized controlled clinical trials, the gold standard to determine treatment efficacy against control, have demonstrated advantages of skin substitutes for the treatment of chronic diabetic foot ulcers in comparison to standard of care. " 10/01/2019 - "We therefore performed a systematic review and meta-analysis on the efficacy of healing diabetic foot ulcers with biologic skin substitutes. " 04/01/2014 - "An exploratory clinical study on the safety and efficacy of an autologous fibroblast-seeded artificial skin cultured with animal product-free medium in patients with diabetic foot ulcers." 01/01/2021 - "We found no studies on epidermal skin substitutes for diabetic foot ulcers. "

Related Drugs and Biologics

1.	Collagen
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Biopolymers (Biopolymer)
4.	Proteins (Proteins, Gene)
5.	Elastin
6.	Apligraf
7.	Cytokines
8.	Graphite
9.	Biocompatible Materials (Biomaterials)
10.	Gelatin

Related Therapies and Procedures

1.	Therapeutics
2.	Biological Dressings
3.	Skin Transplantation (Skin Grafting)
4.	Debridement
5.	Autologous Transplantation