Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)

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607 relevant articles (14 outcomes, 35 trials/studies) found for this Disease

Description: A systemic, large-cell, non-Hodgkin, malignant lymphoma characterized by cells with pleomorphic appearance and expressing the CD30 ANTIGEN. These so-called "hallmark" cells have lobulated and indented nuclei. This lymphoma is often mistaken for metastatic carcinoma and MALIGNANT HISTIOCYTOSIS.

Also Known As:

Ki 1 Lymphoma; Lymphoma, Large-Cell, Anaplastic; CD30+ Anaplastic Large-Cell Lymphoma; Ki-1 Lymphoma; Systemic Anaplastic Large-Cell Lymphoma; Anaplastic Large Cell Lymphoma; Anaplastic Large-Cell Lymphomas; CD30 Positive Anaplastic Large Cell Lymphoma; CD30+ Anaplastic Large Cell Lymphoma; Ki-1 Lymphomas; Large-Cell Lymphoma, Anaplastic; Large-Cell Lymphomas, Anaplastic; Lymphoma, Anaplastic Large-Cell; Lymphoma, Ki-1; Lymphomas, Anaplastic Large-Cell; Lymphomas, Ki-1; Systemic Anaplastic Large Cell Lymphoma; CD30-Positive Anaplastic Large-Cell Lymphoma; Lymphoma, Large-Cell, Ki-1

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lymphoma (Lymphomas)
2.	Non-Hodgkin Lymphoma (Lymphosarcoma)
3.	Mycosis Fungoides
4.	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome)
5.	Neoplasms (Cancer)

Experts

1.	Medeiros, L Jeffrey: 12 articles (09/2007 - 03/2003)
2.	Rassidakis, George Z: 12 articles (09/2007 - 03/2003)
3.	Lai, Raymond: 9 articles (10/2006 - 03/2003)
4.	Leventaki, Vasiliki: 5 articles (09/2007 - 08/2003)
5.	Amin, Hesham M: 5 articles (10/2006 - 08/2003)
6.	Merz, Hartmut: 4 articles (05/2004 - 04/2002)
7.	Lai, R: 3 articles (08/2008 - 03/2000)
8.	Amin, H M: 3 articles (08/2008 - 09/2001)
9.	Pulford, Karen: 3 articles (10/2007 - 02/2004)
10.	Lim, Megan S: 3 articles (09/2007 - 08/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Anaplastic Large-Cell Lymphoma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 06/01/2003 - "Secondary cutaneous anaplastic large cell lymphoma treated with liposomal doxorubicin (Doxil) leading to complete remission." 09/01/2002 - "From 1985 to 1998, 39 patients with Stage I or II World Health Organization classification anaplastic large cell lymphoma (ALCL; n = 20), peripheral T-cell lymphoma, unspecified (PTCLu; n = 11), or nasal-type NK/T-cell lymphoma (NKTCL; n = 8) were treated using doxorubicin-based chemotherapy (median, 6 cycles) with (n = 24) or without (n = 15) radiotherapy (median dose, 40 Gy)" 12/01/2006 - "The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression." 11/01/1993 - "RESULTS: The index patient and second patient were diagnosed as having Ki-1-positive anaplastic large-cell lymphoma by immunophenotyping and underwent cyclophosphamide, doxorubicin, prednisone, and vincristine (CHOP) chemotherapy with complete remission" Order ALL the reference details at left...
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 12/01/2002 - "ALK is a tyrosine kinase oncogene initially found to be rearranged in anaplastic large-cell lymphomas (ALCL)" 09/01/2001 - "Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein." 08/15/2000 - "Immune response to the ALK oncogenic tyrosine kinase in patients with anaplastic large-cell lymphoma." 12/01/1999 - "The tyrosine kinase NPM-ALK, associated with anaplastic large cell lymphoma, binds the intracellular domain of the surface receptor CD30 but is not activated by CD30 stimulation." 12/01/1994 - "We have recently found a novel hyperphosphorylated 80-kD protein tyrosine kinase, p80, in a human Ki-1 lymphoma with this translocation" Order ALL the reference details at left...
3.	Phosphotransferases (Kinase)IBA 10/01/2008 - "Sixty-eight cases of anaplastic large cell lymphoma (44%) showed p63 nuclear positivity (41% of anaplastic large cell kinase positive and 47% of anaplastic large cell kinase negative)" 09/01/2007 - "NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma." 02/01/2007 - "Only a few scattered cells expressed CD30, but they showed no staining for anaplastic large-cell lymphoma kinase (ALK)" 10/01/2006 - "Some populations of IMT have anaplastic large cell lymphoma kinase (ALK) gene rearrangements" 07/01/2004 - "In one case, anaplastic large cell lymphoma kinase (ALK) was identified with immunostaining and chromosomal rearrangement of ALK was detected by fluorescence in situ hybridization (FISH)" Order ALL the reference details at left...