|1.||Acquired Immunodeficiency Syndrome (AIDS)
|3.||Cytomegalovirus Infections (Inclusion Disease)
|5.||Retinal Detachment (Retinal Detachments)
|1.||Jabs, Douglas A: 23 articles (06/2013 - 01/2002)|
|2.||Studies of Ocular Complications of AIDS Research Group: 9 articles (05/2011 - 03/2002)|
|3.||Kempen, John H: 9 articles (09/2008 - 01/2002)|
|4.||Thorne, Jennifer E: 8 articles (06/2012 - 05/2003)|
|5.||Kuppermann, Baruch D: 7 articles (01/2010 - 01/2003)|
|6.||Dunn, J P: 6 articles (06/2013 - 05/2000)|
|7.||Cytomegalovirus Retinitis and Viral Resistance Study Group: 6 articles (04/2007 - 01/2001)|
|8.||Van Natta, Mark: 5 articles (06/2013 - 10/2002)|
|9.||Dix, Richard D: 5 articles (03/2013 - 03/2003)|
|10.||Meinert, Curtis L: 5 articles (06/2012 - 03/2002)|
|1.||Ganciclovir (Cytovene)FDA LinkGeneric
01/01/2014 - "Cytomegalovirus Retinitis in an ALL Child during Maintenance Therapy Treated Successfully with Intravenous Ganciclovir."
08/01/2008 - "Cytomegalovirus retinitis affects 0% to 16.5% of HIV-infected patients and is treated successfully with intravitreal ganciclovir in South Africa and Botswana. "
07/10/1997 - "For the treatment of cytomegalovirus retinitis, the sustained-release ganciclovir implant is more effective than intravenous ganciclovir, but patients treated with a ganciclovir implant alone remain at greater risk for the development of cytomegalovirus disease outside of the treated eye."
09/07/1995 - "Oral ganciclovir is safe and effective as maintenance therapy for cytomegalovirus retinitis and is more convenient for patients to take than intravenous ganciclovir."
03/01/2012 - "Intravitreal ganciclovir maintenance injection for cytomegalovirus retinitis: efficacy of a low-volume, intermediate-dose regimen."
01/09/1995 - "In light of the previously reported survival benefit seen in patients treated with foscarnet, these data support the use of foscarnet for the initial treatment of cytomegalovirus retinitis."
05/01/1994 - "Pharmacodynamic relationship of pharmacokinetic parameters of maintenance doses of foscarnet and clinical outcome of cytomegalovirus retinitis."
03/01/1994 - "Intravenous foscarnet administration for treatment of cytomegalovirus retinitis."
09/01/1992 - "Recently the Food and Drug Administration approved the drug foscarnet for treatment of cytomegalovirus retinitis. "
11/01/1991 - "Foscarnet approved for cytomegalovirus retinitis."
|3.||cidofovir (Vistide)FDA Link
04/01/1995 - "Cidofovir (also known as HPMPC) appears to be safe and effective for the local treatment of cytomegalovirus retinitis, providing a long duration of antiviral effect. "
04/01/1995 - "In this study we evaluated the safety and efficacy of the nucleoside phosphonate analogue intravitreal cidofovir to treat cytomegalovirus retinitis in humans. "
04/01/2011 - "Intraocular pharmacokinetics of a crystalline lipid prodrug, octadecyloxyethyl-cyclic-cidofovir, for cytomegalovirus retinitis."
08/01/2005 - "Cidofovir (CDV) is a broad-spectrum antiviral agent that has been approved for clinical use in the treatment of cytomegalovirus retinitis. "
05/01/2004 - "Cidofovir (Vistide) is an antiviral marketed for the treatment of cytomegalovirus retinitis. "
01/01/2002 - "Valganciclovir: a new treatment for cytomegalovirus retinitis."
08/01/2002 - "A safety study of oral valganciclovir maintenance treatment of cytomegalovirus retinitis."
04/11/2002 - "A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis."
01/01/2010 - "Valganciclovir in the treatment of cytomegalovirus retinitis in HIV-infected patients."
04/01/2006 - "Diagnosis of cytomegalovirus retinitis was made, and the patient began induction therapy with oral valganciclovir 900 mg twice a day for 3 weeks. "
|5.||Protease Inhibitors (Protease Inhibitor)IBA
11/01/1999 - "Cytomegalovirus retinitis in advanced HIV-infected patients treated with protease inhibitors: incidence and outcome over 2 years."
08/20/1999 - "Incidence and risk factors for developing cytomegalovirus retinitis in HIV-infected patients receiving protease inhibitor therapy. "
08/01/1997 - "To report the observation that anti-retroviral therapy that includes a protease inhibitor can induce the regression of cytomegalovirus retinitis without requiring specific anticytomegalovirus drug therapy. "
10/01/2001 - "Protease inhibitor therapy is associated with markedly prolonged time to relapse and improved survival in AIDS patients with cytomegalovirus retinitis."
10/01/1998 - "Improved outcome of cytomegalovirus retinitis in AIDS patients after introduction of protease inhibitors."
07/01/1986 - "Reports of DHPG treatment of cytomegalovirus retinitis."
09/01/1987 - "DHPG appears to be effective in treating cytomegalovirus retinitis but long-term suppressive therapy would be necessary to prevent recurrence of the retinitis."
09/01/1987 - "Treatment of cytomegalovirus retinitis with DHPG in a patient with AIDS."
10/01/1990 - "In the prefinal stage (on average 6 months ante finem), 25% of these patients developed typical, rapidly progressing cytomegalovirus retinitis with intraretinal hemorrhages and necrosis, which responded well to combined intravenous and intravitreal DHPG therapy. "
01/01/1989 - "Given at an early stage and without discontinuation, DHPG is an effective means of preventing or delaying blindness caused by cytomegalovirus retinitis in AIDS patients. "
01/01/2013 - "The purpose of this study is to report the novel finding of extensive retinal arteriolar occlusions and neovascularization in immunocompetent patients with cytomegalovirus retinitis. "
01/01/2013 - "Five of 7 (71%) elderly immunocompetent patients with cytomegalovirus retinitis had retinal arteriolar occlusions versus 2 of 8 (25%) elderly immunocompromised patients and 1 of 19 (5%) younger HIV-infected patients. "
01/01/2013 - "Retinal arteriolar occlusions due to cytomegalovirus retinitis in elderly patients without HIV."
05/01/2012 - "The mean CD4+ lymphocyte counts of the patients with retinal microvasculopathy and cytomegalovirus retinitis were 108.5 cells/µL and 69.4 cells/µL, respectively. "
07/01/2007 - "To assess the retinal nerve fiber layer thickness in children with human immunodeficiency virus disease without cytomegalovirus retinitis or visual symptoms. "
|8.||Antiviral Agents (Antivirals)IBA
06/01/1997 - "Cytomegalovirus retinitis in orthotopic liver transplant patients may not require life-long maintenance therapy with antiviral agents."
01/01/1993 - "The use of rHuGM-CSF has resulted in patient benefit as shown by reduced infections (MDS and AA), reduced days in intensive care (ABM transplant), better adherence to cancer chemotherapy protocols, and the ability to use full doses of antiviral drugs in AIDS and cytomegalovirus retinitis. "
09/01/2014 - "To evaluate the relationship between aqueous inflammation cytokines and cytomegalovirus (CMV) particles in patients with cytomegalovirus retinitis (CMVR), and evaluate the changes in aqueous inflammation cytokines during multiple intravitreal injections of antiviral drugs for CMVR. "
01/01/1996 - "Intravitreal injections of ganciclovir provide a useful adjunct or alternative treatment for cytomegalovirus retinitis in AIDS patients when toxicity or progression is seen with systemic administration of antiviral drugs. "
12/15/1988 - "Ganciclovir and foscarnet are investigational antiviral drugs that appear to be effective in treating cytomegalovirus retinitis. "
|9.||Intravenous Immunoglobulins (IVIG)FDA Link
01/15/1986 - "Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus."
05/15/1986 - "Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine."
01/15/1986 - "Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. "
01/15/1986 - "Treatment of cytomegalovirus retinitis with dihydroxy propoxymethyl guanine."
09/01/1985 - "We describe the use of an acyclic nucleoside 9-[2-hydroxy-1-(hydroxymethyl) ethoxy methyl]guanine (BW B759U), in the treatment of two patients with cytomegalovirus retinitis. "
|1.||Highly Active Antiretroviral Therapy (HAART)
03/01/2014 - "Cytomegalovirus retinitis was significantly associated with CD4+ cell count <50 cells/μL (p = 0.001; OR 5.50; 95% CI 1.95, 15.5), HAART-naive status (p = 0.02; OR 0.23; 95% CI 0.07, 0.79), and lower best-corrected visual acuity (p<0.001; OR 5.44; 95% CI 2.11, 14.0). "
06/01/2012 - "Incidence of cytomegalovirus retinitis in the era of highly active antiretroviral therapy."
04/01/2012 - "To quantify the frequencies of the common causes of visual acuity loss for HIV-infected patients with cytomegalovirus retinitis (CMVR) in the era of highly active antiretroviral therapy(HAART). "
04/01/2012 - "Causes of visual acuity loss among HIV-infected patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy in Chiang Mai University Hospital."
05/01/2011 - "Cytomegalovirus retinitis was associated with a substantial risk of incident VF loss, but the incidence is approximately 6-fold lower than that observed in the pre-HAART era. "
07/01/1996 - "Intravitreal injections can be effective in controlling cytomegalovirus retinitis in patients who are intolerant of or refuse systemic therapy."
10/31/2001 - "This implantable scleral plug was supposed to be advantageous for diseases such as cytomegalovirus retinitis that respond to repeated intravitreal injections and for vitreoretinal disorders that require vitrectomy."
09/01/2007 - "Cytomegalovirus retinitis following intravitreal injection of triamcinolone: report of two cases."
01/01/2007 - "There are many effective interventions, via various routes (intravenous [IV], oral [OR], intravitreal injection [IVT] and intraocular implantation [IMP]), for treating cytomegalovirus retinitis (CMVR) that have become available. "
09/01/1998 - "[Intravitreal injection of cidofovir in cytomegalovirus retinitis]."
12/01/1989 - "The retinal detachment could not be conclusively attributed to the injections and was probably a secondary complication of cytomegalovirus retinitis. "
07/15/1996 - "To evaluate the efficacy of intravitreous cidofovir injections alone for initial and maintenance therapy for cytomegalovirus retinitis. "
04/01/1995 - "In a dose-escalating efficacy study (Group 2), eight eyes of seven patients received 11 injections of cidofovir as sole treatment for cytomegalovirus retinitis. "
08/01/1997 - "We followed up 97 eyes of 63 patients with acquired immunodeficiency syndrome (AIDS) who had cytomegalovirus retinitis and had been treated with up to nine 20-microgram intravitreal cidofovir injections. "
11/01/2005 - "The high-dose, alternate-week intravitreal ganciclovir injections for cytomegalovirus retinitis in acquired immune deficiency syndrome patients on highly active antiretroviral therapy."
04/15/1986 - "The cytomegalovirus retinitis recurred in four patients (the other two were lost to follow-up), but retreatment usually led to remission. "
01/01/1996 - "The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir. "
07/01/2010 - "Cytomegaloviral retinitis from chronic immunosuppression following solid organ transplant surgery."
09/01/2008 - "Bilateral toxoplasma retinochoroiditis simulating cytomegalovirus retinitis in an allogeneic bone marrow transplant patient."
11/01/2004 - "Valgancyclovir as maintenance therapy for cytomegalovirus retinitis in a lung transplant patient--a case report."
06/01/2002 - "Clinical profile and immunological status of cytomegalovirus retinitis in organ transplant recipients."
04/01/1996 - "Cytomegalovirus retinitis after heart transplant: a case report."