Diabetic Foot

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818 relevant articles (67 outcomes, 118 trials/studies) found for this Disease

Description: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.

Also Known As:

Diabetic Feet; Feet, Diabetic; Foot, Diabetic; Foot Ulcer, Diabetic

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18449

Vascular Diseases: 7172

Diabetic Angiopathies: 918

Diabetic Foot: 818

Skin and Connective Tissue Diseases

Endocrine System Diseases: 390

Diabetes Mellitus: 22586

Diabetes Complications: 2235

Diabetic Neuropathies: 1751

Diabetic Foot: 818

Diabetic Angiopathies: 918

Diabetic Foot: 818

Related Diseases

1.	Ulcer
2.	Infection
3.	Wounds and Injuries (Trauma)
4.	Osteomyelitis
5.	Syndrome
131 Diseases and 601 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Armstrong, David G: 12 articles (06/2008 - 07/2002)
2.	Lipsky, Benjamin A: 7 articles (09/2007 - 02/2005)
3.	Boulton, Andrew J M: 6 articles (06/2008 - 09/2002)
4.	Lavery, Lawrence A: 6 articles (06/2008 - 07/2002)
5.	Citron, Diane M: 5 articles (02/2008 - 11/2005)
6.	Goldstein, Ellie J C: 4 articles (02/2008 - 08/2006)
7.	Merriam, C Vreni: 4 articles (02/2008 - 08/2006)
8.	Jude, E B: 4 articles (03/2007 - 04/2000)
9.	Orudzheva, S A: 4 articles (05/2005 - 01/2001)
10.	Boulton, A J: 4 articles (11/2001 - 04/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diabetic Foot:

1.	Anti-Bacterial Agents (Antibiotics)IBA 05/01/2008 - "The aim of this paper is to review evidence for the efficacy of new antibiotics in the management of SSSIs, including any data relating specifically to the diabetic foot, and to consider where they might fit into the therapeutic armory against DFI." 04/01/2008 - "A prospective study was carried out on patients with diabetic foot lesions to determine their clinical characteristics, the spectrum of aerobic microbial flora and to assess their comparative in vitro susceptibility to the commonly used antibiotics" 05/01/2005 - "The effect of different antibiotics on the outcome of surgical care in the management of diabetic foot was investigated" 05/01/2004 - "The use of antibiotics in the diabetic foot." 03/09/2002 - "Moreover, the use of antibiotics with potent selection of resistance such as rifampicine and fluoroquinolone, requires that bone biopsies be taken, which is not easy in all the diabetic foot care centres" Get all the results and reference details, order at left...
2.	platelet-derived growth factor BB (becaplermin)FDA Link 06/01/2005 - "CONCLUSION: Although the sample size was not large enough to demonstrate that the incidence of healing in the OASIS group was statistically superior (P = .055), the study results showed that treatment with OASIS is as effective as Regranex in healing full-thickness diabetic foot ulcers by 12 weeks." 10/01/2002 - "Results of this analysis suggest that becaplermin may ultimately be more cost-effective for the treatment of chronic diabetic foot ulcers than other treatment modalities, despite its higher initial dollar cost" 01/01/2001 - "CONCLUSIONS: Becaplermin may be a cost-effective treatment for neuropathic diabetic foot ulcers in a wide range of European settings" 01/01/2003 - "METHODS: The DFS-SF was created through the analysis of data from a double-blind, placebo-controlled, randomised trial of the efficacy and safety of becaplermin (recombinant human platelet-derived growth factor BB) in the treatment of chronic, full-thickness, neuropathic, diabetic foot ulcers" 01/01/2001 - "Clinical studies on gene therapy for diabetic foot ulcers are only available for the local application of human recombinant PDGF-BB growth factor" Get all the results and reference details, order at left...
3.	OxygenIBA 07/01/1992 - "To study the effect of hyperbaric oxygen therapy in chronic diabetic foot lesions, a prospective controlled study was undertaken" 07/15/2006 - "Hyperbaric oxygen therapy consumes very substantial resources--and has the potential to consume far more--that could be better spent on other aspects of management or prevention of diabetic foot ulceration" 07/15/2006 - "RESULTS: Although recognized for reimbursement by Medicare and major insurers, the evidence base for hyperbaric oxygen therapy for diabetic foot care remains weak" 11/12/2005 - "We investigated whether oxygen delivery and muscle metabolism of the lower extremity were factors in diabetic foot disease" 01/01/2004 - "Advances in the treatment of the diabetic foot: Is there a role for adjunctive hyperbaric oxygen therapy?" Get all the results and reference details, order at left...
4.	Piperacillin FDA Link 01/01/2005 - "CONCLUSIONS: Although both study drugs provide safe and effective empiric treatment for moderate-to-severe infected diabetic foot ulcers, piperacillin/tazobactam has the advantage of covering Pseudomonas aeruginosa (bacteriologic success rate of 85.7%), the most commonly isolated gram-negative pathogen in this study." 03/01/1998 - "In this study, 29 patients were hospitalized with a diabetic foot infection and were treated with piperacillin/tazobactam" 10/01/2005 - "We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo microdialysis and found similar penetration for piperacillin but not for tazobactam into inflamed and noninflamed soft tissue." 10/01/2005 - "Penetration of piperacillin and tazobactam into inflamed soft tissue of patients with diabetic foot infection." 12/01/2002 - "Outpatient parenteral antibiotic therapy (OPAT) of diabetic foot infections with piperacillin/tazobactam]" Get all the results and reference details, order at left...
5.	Phenytoin (Dilantin)FDA LinkGeneric 10/01/1991 - "OBJECTIVE: The efficacy of topical phenytoin in the treatment of diabetic foot ulcers was evaluated in a controlled inpatient study" 03/01/2004 - "Phenytoin efficacy in treating the diabetic foot ulcer of a haemodialysis patient." 11/01/2007 - "There was a positive percentage treatment effect in favour of the phenytoin-treated group in one study investigating diabetic foot wounds and one study on chronic wounds" 10/01/1992 - "Response to "Topical phenytoin in diabetic foot ulcers"." 10/01/1991 - "CONCLUSIONS: Phenytoin appears to be useful as a topical agent in promoting the healing of diabetic foot ulcers." Get all the results and reference details, order at left...
6.	Glucose (Dextrose)FDA LinkGeneric 08/01/2006 - "Poor glucose control in the year before admission as a powerful predictor of amputation in hospitalized patients with diabetic foot ulceration." 01/03/2007 - "In conclusion, the anti-diabetic foot ulcer Formula 1 contains ingredients active in modifying tissue glucose homeostasis in vitro but these biological activities could not be associated with improved glycaemic control of diabetes in vivo." 01/03/2007 - "Influence of an anti-diabetic foot ulcer formula and its component herbs on tissue and systemic glucose homeostasis." 07/01/1998 - "Glucose metabolism in chronic diabetic foot ulcers measured in vivo using microdialysis." 01/01/2008 - "Exclusion criteria were severe retinopathy, diabetic nephropathy, amputation of diabetic foot and increased glucose>50 mg/dl" Get all the results and reference details, order at left...
7.	Clindamycin (Cleocin)FDA LinkGeneric 04/01/1993 - "Tissue penetration of clindamycin in diabetic foot infections." 01/01/1984 - "Mixed staphylococcal and anaerobic infections in skin, subcutaneous tissue, the diabetic foot, bone and joints are primary indications for clindamycin" 01/01/1998 - "We evaluated the bacteriological and clinical efficacy of the combination of ciprofloxacin/clindamycin in severe diabetic foot infections and we tried to elucidate the relationship between the vascular status of the lower limbs and the outcome of these infections" 01/01/1998 - "The combination of ciprofloxacin/clindamycin was found to provide an excellent empirical as well as definitive treatment of severe diabetic foot infections" 01/01/1990 - "Oral clindamycin and ciprofloxacin therapy for diabetic foot infections: a retraction." Get all the results and reference details, order at left...
8.	Succinic Acid (Succinate)IBA 01/01/2004 - "Efficacy of derivatives of 3-hydroxypyridine and succinic acid in diabetic patients with the diabetic foot]" 01/01/2005 - "An effect of 3-oxypiridine and succinic acid derivates--emoxipine, reamberin and mexidole--on severity of clinical symptoms of distal sensomotor polyneuropathy, anxiety and depression was studied in 120 patients with diabetes mellitus with syndrome of diabetic foot" 01/01/2005 - "AIM: To compare efficacy of 3-oxypiridine and succinic acid derivatives (emoxipine, reamberine and mexidol) in distal neuropathy (DN) and left ventricular myocardium systolic function (LVMSF) in diabetic patients with diabetic foot syndrome (DFS)" Get all the results and reference details, order at left...
9.	Colistin (Coly-Mycin)FDA Link 12/01/2006 - "Our data allow us to conclude that colistin, alone or in combination with other antimicrobials, is safe and effective when administered as part of a multidisciplinary approach, to promote healing of diabetic foot infection due to MDR P" 12/01/2006 - "Clinical and microbiological efficacy of colistin therapy alone or in combination as treatment for multidrug resistant Pseudomonas aeruginosa diabetic foot infections with or without osteomyelitis." 12/01/2006 - "We retrospectively evaluated the safety and effectiveness of colistin alone or in combination with other antimicrobials in eight diabetic patients with severe diabetic foot infections due to multidrug resistant (MDR) Pseudomonas aeruginosa, complicated in 4 cases by osteomyelitis" 09/01/2006 - "Clinical and microbiological efficacy of colistin therapy in combination with rifampin and imipenem in multidrug-resistant Pseudomonas aeruginosa diabetic foot infection with osteomyelitis." 09/01/2006 - "The evaluation of the safety and effectiveness of colistin in association with rifampin and imipenem in 1 diabetic patient with severe diabetic foot infection (DFI) due to multidrug-resistant (MDR) Pseudomonas aeruginosa, complicated by osteomyelitis, is presented in this "Case Report"" Get all the results and reference details, order at left...
10.	SilverIBA 03/01/2008 - "This in vitro study was conducted to assess the prevalence of silver resistance genes in 112 bacterial isolates obtained from the diabetic foot ulcers of patients attending the Diabetic Foot Clinic at Tameside General Hospital, UK" 01/01/2006 - "MAIN RESULTS: No studies were identified that met with the inclusion criteria AUTHORS' CONCLUSIONS: Despite the widespread use of dressings and topical agents containing silver for the treatment of diabetic foot ulcers, no randomised trials or controlled clinical trials exist that evaluate their clinical effectiveness" 01/27/2005 - "This study investigated the clinical performance and safety of a sustained silver-releasing foam dressing, Contreet Foam, in the treatment of diabetic foot ulcers" 01/27/2005 - "Sustained silver-releasing dressing in the treatment of diabetic foot ulcers." 03/01/2008 - "Prevalence of silver resistance in bacteria isolated from diabetic foot ulcers and efficacy of silver-containing wound dressings." Get all the results and reference details, order at left...
273 Drugs and Important Bio-Agents and 434 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Amputation 11/01/1998 - "The study concluded that multidisciplinary diabetes care team, which includes aggressive foot care and consistent treatment-based risk classification, may be effective in profoundly mitigating the occurrence and recurrence of diabetic foot sequelae, including ulceration and amputation" 09/01/1998 - "This is thought to be achievable because both primary and secondary preventative healthcare strategies are effective in reducing the incidence of diabetic foot ulceration and progression to amputation" 02/01/2007 - "The aim of this prospective study was to evaluate the efficacy of the implementation of the International Consensus on the Diabetic Foot (ICDF) in the area of Pistoia (Tuscany, Italy), in terms of percentage of population screened, reduction of hospitalization, and reduction of lower extremity amputations" 10/01/2004 - "Change in the amputation profile in diabetic foot in a tertiary reference center: efficacy of team working." 01/06/1999 - "Were such an approach to reduce the incidence of diabetes-related amputation by 50 per cent, annual costs for the management of diabetic foot in Sweden would be reduce by SEK 400 million (the value of improved quality of life not taken into consideration)." Get all the results and reference details, order at left...
2.	Debridement 06/01/2002 - "Debridement of the diabetic foot: a podiatric perspective." 04/26/2001 - "Treatment of diabetic foot must include non-weight bearing, long-lasting antibiotic therapy, improving circulation and topical treatment-debridement." 01/01/2001 - "CONCLUSIONS: Early hospitalization, effective glycaemic control, aggressive debridements and patient education in foot care can minimize diabetic foot diseases." 12/01/2001 - "Limb salvage in extensive diabetic foot ulceration-a preliminary clinical study using simple debridement and herbal drinks." 12/01/2005 - "The case discussed here demonstrates how inadequate and disjointed management through lack of communication, education and knowledge of diabetic foot disease can lead to complications requiring amputation and debridement." Get all the results and reference details, order at left...
3.	Transplantation (Transplant Recipients) 10/15/2005 - "Rapid healing of a therapy-refractory diabetic foot after transplantation of autologous bone marrow stem cells]" 07/01/2003 - "The transplantation of autologous keratinocytes may allow faster closure of diabetic foot lesions and subsequently reduce length of hospitalization" 10/01/2007 - "So using free flap transplantation to remedy diabetic foot ulcers can produce excellent or good results, especially in patients with PBFVs over 40 cm/s at the recipient artery." 10/15/2005 - "CONCLUSION: The combined intraarterial and intramuscular transplantation of autologous bone marrow stem cells could constitute a novel, clinically feasible and safe therapy for patients with diabetic foot syndrome" 01/01/2008 - "The transplantation of autologous keratinocytes is a promising therapy for diabetic foot ulcers; however, little is known about their characteristics on a molecular level" Get all the results and reference details, order at left...
4.	Negative-Pressure Wound Therapy 03/01/2006 - "Managing the diabetic foot with the use of vacuum-assisted closure: a call for more studies." 05/01/2006 - "We are introducing new method of the treatment of diabetic foot--VAC--vacuum assisted closure" 11/12/2005 - "Negative pressure wound therapy after partial diabetic foot amputation: a multicentre, randomised controlled trial." 03/01/2008 - "Negative-pressure wound therapy and diabetic foot amputations: a retrospective study of Payer Claims Data." 09/01/2007 - "Negative-pressure wound therapy and diabetic foot amputations: a retrospective study of payer claims data." Get all the results and reference details, order at left...
5.	Skin Transplantation (Skin Grafting) 11/01/2004 - "Three wound dehiscences (3/21 = 14.3%) occurred in 2 diabetic foot patients, which were cured by skin grafting" 07/01/2008 - "CONCLUSION: Split-skin grafting is an effective method of managing diabetic foot ulcers as, compared with the conservative dressings used in this study, it reduced healing times and the length of hospital stay, while donor-site morbidity was minimal." 04/01/2005 - "Skin grafting techniques for soft-tissue coverage of diabetic foot and ankle wounds." 09/01/2004 - "To circumvent these problems, the authors developed a therapeutic approach using buried chip skin grafting to close granulation wound beds in diabetic feet" 06/01/2000 - "Skin grafting of partial-thickness burns in the diabetic foot." Get all the results and reference details, order at left...
74 Therapies and Procedures and 466 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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