|1.||Adlercreutz, Herman: 20 articles (08/2013 - 05/2002)|
|2.||Thompson, Lilian U: 17 articles (06/2014 - 01/2002)|
|3.||Saarinen, Niina M: 11 articles (01/2014 - 12/2004)|
|4.||Linseisen, Jakob: 8 articles (03/2014 - 06/2004)|
|5.||Chang-Claude, Jenny: 7 articles (03/2012 - 06/2004)|
|6.||McCann, Susan E: 6 articles (02/2015 - 10/2002)|
|7.||Chen, Jianmin: 6 articles (01/2013 - 01/2002)|
|8.||Zamora-Ros, Raul: 5 articles (11/2015 - 03/2013)|
|9.||Power, Krista A: 5 articles (06/2014 - 03/2006)|
|10.||Overvad, Kim: 4 articles (11/2015 - 10/2004)|
11/01/1991 - "Since lignans have been suggested to have some cancer-protective effects, flaxseed, the most abundant source of lignan precursors, was tested for its effect on early markers of risk for mammary carcinogenesis. "
01/01/1997 - "Epidemiologic, in vitro, and in vivo studies support the hypothesis that mammalian lignans have cancer protective effects. "
12/28/2014 - "A protective effect of lignans on the development of oesophageal cancer in humans has recently been demonstrated, and the present study aimed to test whether these three phytochemicals synergistically decrease the risk of oesophageal cancer. "
02/01/2010 - "The results of this study suggest that some of these lignans might be valuable as potential cancer chemopreventive agents."
12/01/2007 - "Our previous studies demonstrated that the contents of lignans in various wheat cultivars were significantly associated with anti-tumor activities in APC(Min) mice. "
|2.||Breast Neoplasms (Breast Cancer)
11/01/2015 - "Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. "
06/01/2014 - "Clinical trials show that FS (25 g/day with 50 mg lignans; 32 days) reduces tumour growth in breast cancer patients and lignans (50 mg/day; 1 year) reduces risk in premenopausal women. "
02/01/2014 - "In this study, we evaluated whether tetrahydrofurofuran-type lignans derived from Magnoliae Flos, commonly used in traditional Asian medicine to treat inflammatory diseases, could block breast cancer-mediated bone loss. "
01/01/2013 - "The above results after properly designed animal studies could highlight a potential role of pumpkin seed's lignans in breast cancer prevention and/or treatment. "
07/01/2010 - "In this study, we conducted meta-analyses on the association between lignans and breast cancer risk. "
|3.||Cardiovascular Diseases (Cardiovascular Disease)
09/01/2014 - "The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms."
09/01/2012 - "Pre-clinical studies suggest that sesame and its lignans induce beneficial changes in risk factors related to cardiovascular disease. "
12/01/2009 - "Pre-clinical studies suggest that sesame and its lignans induce beneficial changes in risk factors related to cardiovascular disease and increase the bioavailability of mammalian lignans. "
09/01/2014 - "In the present review, we highlight SCE and its lignans as promising resources for the development of safe, effective, and multi-targeted agents against cardiovascular disease. "
10/01/2010 - "The associations between lignans and decreased risk of cardiovascular disease are promising, but they are yet not well established, perhaps due to low lignan intakes in habitual Western diets. "
|4.||Prostatic Neoplasms (Prostate Cancer)
03/01/2005 - "Clinical intervention studies and experimental studies with lignan-rich diets suggest that lignans may have inhibitory effects on prostate cancer, but no clinical or experimental studies with purified lignans have been published. "
04/01/2004 - "In comparison, few studies have investigated the effects of lignans in breast and prostate cancer. "
02/01/2010 - "No unequivocal prostate cancer risk reduction has been found for lignans in epidemiological studies, suggesting that lignan concentrations found in populations consuming a regular non-supplemented diet are not chemopreventive in prostate cancer. "
02/01/2010 - "Assessment of information to substantiate a health claim on the prevention of prostate cancer by lignans."
08/27/2008 - "These results collectively indicated that these lignans may have chemopreventive or therapeutic actions for prostate cancer through suppressing AR signaling pathway and inducing apoptosis."
|5.||Colonic Neoplasms (Colon Cancer)
01/01/1999 - "Flaxseed has been shown in previous studies to decrease some early markers of colon cancer risk in part because of its lignans. "
03/01/2005 - "Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells."
06/01/2002 - "Experimental evidence also exists for an inhibitory effect of soy and rye bran on prostate-cancer growth and for rye bran or isolated lignans on colon cancer. "
12/01/1998 - "Epidemiological studies have revealed that high levels of lignans and isoflavonoids are frequently associated with low breast, prostate and colon cancer risk, as well as a low risk of coronary heart disease. "
01/01/1999 - "Because flaxseed and lignans are colon cancer protective, it is concluded that, in contrast to other studies, beta-glucuronidase activity may play a beneficial role in their presence by increasing mammalian lignan absorption and enterohepatic circulation."
|1.||Heterologous Transplantation (Xenotransplantation)
|5.||Drug Therapy (Chemotherapy)