Myocardial Stunning (Stunned Myocardium)

Prolonged dysfunction of the myocardium after a brief episode of severe ischemia, with gradual return of contractile activity. It occurs frequently, both in the experimental laboratory and in clinical medicine. Since stunned myocardium occurs adjacent to necrotic tissue after prolonged coronary occlusion, many myocardial infarcts may be a mixture of necrotic and stunned tissue. (Braunwald, Heart Disease, 1992, p1176)
Also Known As:
Stunned Myocardium; Myocardium, Stunned; Stunning, Myocardial; Hibernation, Myocardial; Myocardial Hibernation
Networked: 916 relevant articles (78 outcomes, 131 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Ischemia
2. Reperfusion Injury
3. Myocardial Infarction
4. Infarction
5. Myocardial Ischemia (Ischemic Heart Diseases)


1. McIntyre, Christopher W: 8 articles (01/2013 - 01/2008)
2. Weiss, Harvey R: 7 articles (01/2007 - 05/2002)
3. Hara, Tetsuya: 6 articles (02/2013 - 01/2005)
4. Cho, Sungsam: 6 articles (02/2013 - 01/2005)
5. Yoshitomi, Osamu: 6 articles (02/2013 - 01/2005)
6. Sumikawa, Koji: 6 articles (02/2013 - 01/2005)
7. Gelpi, Ricardo J: 6 articles (09/2012 - 01/2003)
8. Scholz, Peter M: 6 articles (01/2007 - 05/2002)
9. Burton, James O: 5 articles (01/2013 - 01/2008)
10. Donato, Martín: 5 articles (09/2012 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myocardial Stunning:
1. DobutamineFDA LinkGeneric
2. simendan (Levosimendan)IBA
3. Adenosine Triphosphate (ATP)IBA
4. AdenosineFDA LinkGeneric
5. CalciumIBA
6. CatalaseIBA
7. OxygenIBA
8. Free RadicalsIBA
9. Free Radical ScavengersIBA
10. IsofluraneFDA LinkGeneric

Therapies and Procedures

1. Angioplasty (Angioplasty, Transluminal)
2. Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump)
3. General Anesthesia
4. Induced Heart Arrest (Cardioplegia)
5. Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
01/01/1992 - "To observe the clinical course after reperfusion and recovery from myocardial stunning of the left ventricular anterior wall, we prospectively reviewed and analyzed cardiac enzymes, ECG changes, echocardiograms, and cineangiograms in 8 patients with the acute ischemic syndrome who fulfilled the following criteria: 1) no history of previous myocardial infarction, 2) repeated and/or prolonged episodes of chest pain, 3) critical stenosis of the left anterior descending artery with wall motion abnormalities, 4) successful emergency percutaneous transluminal coronary angioplasty, and 5) normal wall motion on repeat cineangiography 4 to 8 weeks later. "
01/01/2001 - "Percutaneous transluminal coronary angioplasty is associated with complications such as myocardial stunning and accelerated restenosis, which at least in part are mediated by oxygen free radicals. "
06/16/2004 - "The calcium sensitizer levosimendan improves the function of stunned myocardium after percutaneous transluminal coronary angioplasty in acute myocardial ischemia."
01/01/1992 - "The present study was undertaken to test and compare the protective effect of calcium antagonists [nisoldipine (NIS) and nifedipine (NIF)] and nitrates (NIT) against myocardial stunning in patients with coronary artery disease undergoing percutaneous transluminal coronary angioplasty (PTCA) with prolonged inflation as PTCA represents a model of induced acute and severe ischemia for a brief period and might cause myocardial stunning. "