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Hypereosinophilic Syndrome (Loeffler Endocarditis)

A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.
Also Known As:
Loeffler Endocarditis; Idiopathic Hypereosinophilic Syndrome; Endocarditis, Loeffler; Leukemia, Eosinophilic; Hypereosinophilic Syndrome, Idiopathic; Endocarditis, Loefflers; Eosinophilic Leukemia; Eosinophilic Leukemias; Hypereosinophilic Syndromes; Hypereosinophilic Syndromes, Idiopathic; Idiopathic Hypereosinophilic Syndromes; Leukemias, Eosinophilic; Loefflers Endocarditis; Syndrome, Hypereosinophilic; Syndrome, Idiopathic Hypereosinophilic; Syndromes, Hypereosinophilic; Syndromes, Idiopathic Hypereosinophilic; Endocarditis, Loeffler's; Loeffler's Endocarditis
Networked: 747 relevant articles (68 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypereosinophilic Syndrome (Loeffler Endocarditis)
2. Eosinophilia
3. Neoplasms (Cancer)
4. Pdgfra-Associated Chronic Eosinophilic Leukemia
5. Inflammation (Inflammations)

Experts

1. Klion, Amy D: 26 articles (01/2022 - 06/2003)
2. Roufosse, Florence: 14 articles (01/2022 - 09/2002)
3. Rothenberg, Marc E: 13 articles (01/2022 - 01/2004)
4. Tefferi, Ayalew: 13 articles (02/2010 - 05/2002)
5. Helbig, Grzegorz: 12 articles (01/2020 - 05/2005)
6. Gotlib, Jason: 12 articles (12/2015 - 03/2003)
7. Simon, Hans-Uwe: 11 articles (12/2016 - 07/2002)
8. Gleich, Gerald J: 10 articles (01/2022 - 05/2002)
9. Pardanani, Animesh: 10 articles (10/2018 - 05/2002)
10. Gilliland, D Gary: 10 articles (11/2005 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypereosinophilic Syndrome:
1. Imatinib Mesylate (Gleevec)FDA Link
2. mepolizumabIBA
3. Interferon-alpha (Interferon Alfa)IBA
4. Monoclonal AntibodiesIBA
5. benralizumabIBA
6. Adrenal Cortex Hormones (Corticosteroids)IBA
7. Interleukin-5 (Interleukin 5)IBA
8. reslizumabIBA
9. Prednisone (Sone)FDA LinkGeneric
10. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA

Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Stem Cell Transplantation
4. Precision Medicine
5. Off-Label Use