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Hypereosinophilic Syndrome (Loeffler Endocarditis)

A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of eosinophils in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs. It is often referred to as idiopathic.
Also Known As:
Loeffler Endocarditis; Idiopathic Hypereosinophilic Syndrome; Endocarditis, Loeffler; Leukemia, Eosinophilic; Endocarditis, Loefflers; Eosinophilic Leukemia; Eosinophilic Leukemias; Hypereosinophilic Syndrome, Idiopathic; Hypereosinophilic Syndromes; Hypereosinophilic Syndromes, Idiopathic; Idiopathic Hypereosinophilic Syndromes; Leukemias, Eosinophilic; Loefflers Endocarditis; Syndrome, Hypereosinophilic; Syndrome, Idiopathic Hypereosinophilic; Syndromes, Hypereosinophilic; Syndromes, Idiopathic Hypereosinophilic; Endocarditis, Loeffler's; Loeffler's Endocarditis
Networked: 619 relevant articles (54 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypereosinophilic Syndrome (Loeffler Endocarditis)
2. Eosinophilia
3. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
4. Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
5. Neoplasms (Cancer)

Experts

1. Tefferi, Ayalew: 17 articles (03/2010 - 05/2002)
2. Gotlib, Jason: 14 articles (12/2015 - 03/2003)
3. Cools, Jan: 13 articles (04/2014 - 03/2003)
4. Pardanani, Animesh: 11 articles (02/2010 - 05/2002)
5. Gilliland, D Gary: 11 articles (05/2006 - 03/2003)
6. Valent, Peter: 9 articles (10/2014 - 01/2005)
7. Reiter, Andreas: 9 articles (10/2014 - 07/2004)
8. Kantarjian, Hagop: 9 articles (06/2013 - 09/2002)
9. Klion, Amy D: 9 articles (02/2013 - 06/2003)
10. Cross, Nicholas C P: 9 articles (03/2011 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hypereosinophilic Syndrome:
1. imatinib (Gleevec)FDA Link
2. Interferon-alpha (Interferon Alfa)FDA Link
3. mepolizumabIBA
4. Prednisone (Sone)FDA LinkGeneric
5. AntibodiesIBA
6. Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
7. Interleukin-5 (Interleukin 5)IBA
8. Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
9. Phosphotransferases (Kinase)IBA
10. Cyclosporine (Ciclosporin)FDA LinkGeneric

Therapies and Procedures

1. Aftercare (After-Treatment)
2. Stem Cell Transplantation
3. Transplants (Transplant)
4. Off-Label Use
5. Biological Therapy