Peplomycin

07/01/2003 - "This study was preliminary clinical practice of tumor imaging and radioimmunoguided surgery (RGS) using (99m)Tc-PPM (peplomycin) as a tumor tracer. "
12/01/1994 - "Patients with superficial transitional cell cancer of the urinary bladder were entered into a randomized trial to compare the effects of immediate and short-term postoperative instillation of peplomycin sulfate with simple irrigation. "
02/01/1979 - "[Studies on the clinical effect of NK 631 for oral-cavity cancers (author's transl)]."
12/10/2020 - "Each patient received preoperative external beam irradiation to the primary tumor and lymphatics (2 Gy per day for approximately 3 weeks) concurrent with pepleomycin (2.5 mg/day). "
07/01/2008 - "Although the antiproliferative activity of peplomycin declined with increasing cell density, peplomycin showed tumor-specific cytotoxicity at any cell density. "

10/20/1987 - "[Pharmacokinetic study of peplomycin given by continuous infusion from the vagina or cervix in squamous cell carcinoma of the uterine cervix]."
01/01/1983 - "A phase II trial has been performed in squamous cell carcinoma of the lung using peplomycin. "
01/01/1983 - "A phase II trial of peplomycin in squamous cell carcinoma of the lung."
01/01/2017 - "Retrospective Investigation of Cutaneous Squamous Cell Carcinoma on the Lip Treated with Peplomycin Administered Through a Superficial Temporal Artery."
01/01/2015 - "Immunomodulatory effects of peplomycin on immunosuppressive and cytotoxic cells in the lesional skin of cutaneous squamous cell carcinoma."

07/01/1991 - "A new dosage form (PEP-CH) of peplomycin was tested for therapeutic efficacy against lymph node metastasis in mice. "
03/01/1988 - "Enhanced therapeutic efficacy on lymph node metastasis by the use of peplomycin adsorbed on small activated carbon particles."
04/01/1999 - "Interestingly, continuous subcutaneous infusion of peplomycin for the lymph node metastasis significantly improved the warty lesions of porokeratosis. "
04/01/1988 - "Activated carbon particles adsorbing peplomycin (PEP-CH) were prepared for chemotherapy against lymphatic metastasis. "
04/01/1988 - "In animal experiments using MH 134 tumor, the therapeutic efficacy of PEP-CH on the lymphatic metastasis was greater than that of peplomycin aqueous solution. "

06/01/1988 - "[Experimental study on the effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4 NQO) in rats. "
01/01/1988 - "[Experimental study on the effects of peplomycin on tongue carcinoma induced by 4-nitroquinoline 1-oxide (4NQO) in rats. "
12/01/2004 - "To investigate the mechanism of peplomycin (PEP)-induced apoptosis in liver carcinoma cell line (Bel-7402). "
12/01/2004 - "Peplomycin induces G1-phase specific apoptosis in liver carcinoma cell line Bel-7402 involving G2-phase arrest."
09/01/2001 - "[Influence of peplomycin on pulmonary function (PaO2, %DLco) in patients with oral carcinoma]."

02/01/1990 - "[Clinical evaluation of high dose rate intra-cavitary irradiation in the treatment of uterine cervical cancer, combined with pepleomycin suppository in uterine cavity]."
11/01/1988 - "A continuous subcutaneous infusion of peplomycin was performed on 15 patients with cervical cancer. "
10/20/1983 - "[Therapeutic effect of peplomycin in cervical cancer, with special reference to pathohistological studies]."
02/01/1990 - "Side effects which were followed by the combination therapy were not serious, and so we believe that pepleomycin suppository is a simple method and valuable to supplement radiation therapy of uterine cervical cancer."
03/01/1985 - "From the above findings, arterial infusion of peplomycin was considered to be an effective method of chemotherapy for cervical cancer, and worth being tried as a preoperative therapy too."