Serpentine Asbestos (Chrysotile)

A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)

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Networked: 609 relevant articles (4 outcomes, 97 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yano, Eiji: 11 articles (08/2018 - 06/2008)
2.	Wang, Xiaorong: 11 articles (05/2016 - 12/2010)
3.	Lin, Sihao: 8 articles (05/2016 - 02/2012)
4.	Mossman, Brooke T: 7 articles (12/2018 - 04/2004)
5.	Butnor, Kelly J: 7 articles (05/2011 - 07/2002)
6.	Kohyama, Norihiko: 6 articles (04/2020 - 01/2005)
7.	Toyokuni, Shinya: 6 articles (04/2020 - 11/2008)
8.	Lan, Yajia: 6 articles (08/2014 - 02/2012)
9.	Bernstein, David M: 5 articles (01/2022 - 12/2003)
10.	Cui, Yan: 5 articles (10/2020 - 08/2018)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/01/1983 - "Compared with data for chrysotile miners and millers, chrysotile textile workers were found to experience significantly greater lung cancer mortality at lower lifetime cumulative exposure levels. " 08/01/2018 - "In order to determine whether respirable chrysotile fiber dust of China caused lung cancer, four major chrysotile-producing mine areas in China were selected for this study. " 08/01/2014 - "This study was carried out to evaluate exposure-specific lung cancer risks in Chinese chrysotile textile workers and mining workers. " 11/01/1983 - "These findings support the conclusion from the South Carolina study that the risk of lung cancer in textile processing is very much greater than in chrysotile production and probably than in the friction products industry. " 05/01/1978 - "All malignant pulmonary neoplasms found during this study occurred in animals treated with chrysotile. "
2.	Neoplasms (Cancer) 01/01/2020 - "A historical cohort study in workers occupationally exposed to chrysotile was set up in the town of Asbest, the Russian Federation, to study their cause-specific mortality, with a focus on cancer. " 03/01/2010 - "In this study we evaluated the morphological, immunohistochemical and functional effects of antigorite fibres in alveolar epithelial cancer cells (A549), a standardized human cell line currently used as a model to study cytotoxicity induced by pharmacological agents. " 10/15/2020 - "In addition, chrysotile from Shannan and XinKang has a stronger effect which may link to cancer than that from Akesai and Mangnai." 01/01/2020 - "A historical cohort study of cancer mortality is being conducted among workers in a chrysotile mine and its enrichment factories in the town of Asbest, Russian Federation. " 01/01/2020 - "This is reassuring for the quality of cancer mortality follow-up of the Asbest chrysotile cohort. "
3.	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/01/1967 - "Studies on the progressiveness of the pulmonary fibrosis caused by chrysotile dust." 08/01/2015 - "In vivo, the genetic deletion of MARCO attenuated the profibrotic environment and pulmonary fibrosis in mice exposed to chrysotile. " 03/01/2006 - "Mineralogical and exposure determinants of pulmonary fibrosis among Québec chrysotile miners and millers." 01/01/1988 - "A diffuse peribronchiolar alveolar and interstitial fibrosing alveolitis was developed in 10 animals following 2 years of exposure consisting of slow intratracheal infusion of 100 mg Canadian chrysotile in 100 ml saline every 2 weeks. " 01/01/2004 - "There is enough evidence to link chrysotile with pulmonary fibrosis and lung cancer in humans, even at low levels of exposure, hence the need to apply the Precautionary Principle for phasing out its use globally. "
4.	Hemolysis 09/01/1983 - "Chrysotile fibers promoted the fusion of human erythrocyte membranes and the hemolysis and fusion of fowl erythrocytes. " 02/01/1983 - "Mechanism of haemolysis by chrysotile fibres." 12/01/1974 - "However chrysotile showed remarkable toxicity and induced hemolysis on heating between 650 and 800 degrees C, compared with the original unheated specimens. " 06/01/1983 - "In the presence of ferritin particles, hemolysis by chrysotile fibers is inhibited at least during the first 10 min. Freeze-fracture studies show that after 20 sec or 2 min of contact between the fibers and the RBC membrane, the intramembranous particles remain randomly distributed over the whole surface of the P-face. " 01/15/2005 - "When their cellular toxicity was assessed, TAFMAG showed no or less comparable to that of chrysotile in the hemolysis and lipid peroxidation of erythrocytes, and also on a MTT assay in RLE-6TN, a rat alveolar epithelial cell line. "
5.	Mesothelioma 01/01/2022 - "The studies of motor vehicle mechanics and in particular workers who serviced chrysotile containing brakes with the majority of the fibers being short provides evidence that motor vehicle mechanics, including workers who were engaged in brake repair, are not at an increased risk of mesothelioma. " 11/01/2021 - "Thus, this study aimed to demonstrate the mesothelioma-inducing potential of chrysotile at the mesothelial cellular level and the function of microRNA-28 in malignantly transformed mesothelial MeT-5A cells. " 12/01/2018 - "Similar studies are needed in other countries to estimate continuing environmental and occupational mesothelioma hazards worldwide, including the contribution from chrysotile." 09/01/2010 - "This study provides support that CSP following inhalation would not initiate an inflammatory response in the lung, and that the chrysotile fibers present do not migrate to, or cause an inflammatory response in the pleural cavity, the site of mesothelioma formation." 12/01/2008 - "The study also identified three mesothelioma cases among white-collar employees at the mine, five in workers in the mine hired by subcontracting firms, and three among workers processing Balangero chrysotile outside the mine. "

Related Drugs and Biologics

1.	Asbestos
2.	Silicon Dioxide (Silica)
3.	Saline Solution
4.	attapulgite (palygorskite)
5.	Sucrose (Saccharose)
6.	Polymers
7.	Kaolin
8.	Immunoglobulin G (IgG)
9.	Bentonite (Montmorillonite)
10.	Crocidolite Asbestos (Blue Asbestos)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Therapeutics
3.	Injections
4.	Catheters
5.	Chemoprevention