Focal Epithelial Hyperplasia

Hyperplasia of the mucous membrane of the lips, tongue, and less commonly, the buccal mucosa, floor of the mouth, and palate, presenting soft, painless, round to oval sessile papules about 1 to 4 mm in diameter. The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. A viral etiology is suspected, the isolated organism being usually the human papillomavirus. (Jablonski, Illustrated Dictionary of Dentistry; Belshe, Textbook of Human Virology, 2d ed, p954)

Also Known As:

Networked: 50 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Focal Epithelial Hyperplasia
2.	Papilloma (Papillomatosis)
3.	Neoplasms (Cancer)
4.	Hyperplasia
5.	Fibroma (Fibromatosis)

Experts

1.	Chiniforush, Nasim: 1 article (01/2022)
2.	Sarabadani, Javad: 1 article (01/2022)
3.	Yazdandoust, Yasaman: 1 article (01/2022)
4.	Allen, Clint T: 1 article (05/2021)
5.	Dodge, Joshua T: 1 article (05/2021)
6.	Mays, Jacqueline W: 1 article (05/2021)
7.	McBride, Alison A: 1 article (05/2021)
8.	Nguyen, Joe Truong: 1 article (05/2021)
9.	Pavletic, Steven Z: 1 article (05/2021)
10.	Van Doorslaer, Koenraad: 1 article (05/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Focal Epithelial Hyperplasia:

1.	DNA (Deoxyribonucleic Acid)IBA 11/01/2011 - "Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis." 11/01/2009 - "Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran." 01/01/2006 - "This report describes the diagnosis of focal epithelial hyperplasia in five Central Amazonian Indians who sought treatment at the Amazonas State Foundation of Tropical Medicine (FMT-AM), using clinical criteria, polymerase chain reaction (PCR) and DNA sequencing." 05/01/1991 - "Human papillomavirus (HPV) DNA in focal epithelial hyperplasia by in situ hybridization." 03/01/1989 - "Detection of human papillomavirus (HPV) DNA in focal epithelial hyperplasia."
2.	Imiquimod (Aldara)FDA LinkGeneric 11/01/2020 - "A case of Heck's disease with primary intestinal lymphangiectasia treated with imiquimod." 07/01/2009 - "Here we report three children of Turkish origin with focal epithelial hyperplasia successfully treated with imiquimod 5% cream. " 07/01/2009 - "Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases." 01/01/2016 - "Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod." 03/01/2010 - "Focal epithelial hyperplasia (Heck's Disease) in two siblings: response to treatment with imiquimod 5% cream."
3.	AntigensIBA 09/01/1985 - "Immunohistochemical evidence of papillomavirus antigen in focal epithelial hyperplasia." 06/01/1983 - "Six oral squamous cell tumours classified as focal epithelial hyperplasia (FEH), Condyloma acuminatum (CA) and squamous cell papilloma (SQP) were subjected to indirect immunoperoxidase staining with anti-human papillomavirus (anti-HPV) antiserum to demonstrate the possible presence of HPV antigens in these lesions. " 01/01/1987 - "A total of 54/206 (26.2%) lesions were observed to express HPV antigens, being found in 45/92 (48.9%) of the squamous cell papillomas/condylomas, in 1/54 fibrous hyperplasias, in 1/8 true fibromas, and in 7/8 (87.5%) of the focal epithelial hyperplasia (FEH) lesions. " 05/01/1991 - "Eighteen cases of focal epithelial hyperplasia (FEH) were investigated for the presence of human papillomavirus (HPV) group specific antigen by immunocytochemistry and HPV types 1, 6, 11, 13, 16, 18 and 32 by DNA in situ hybridization employing biotinylated probes. "
4.	DNA ProbesIBA 01/01/1992 - "In situ hybridization with digoxigenin-labelled DNA probes for the detection of human papillomavirus-induced focal epithelial hyperplasia among Venezuelans." 08/01/1989 - "17 cases of focal epithelial hyperplasia of the oral mucosa (FEH, Heck's disease) were investigated for the presence of human papillomavirus (HPV) nucleic acid sequences by means of in situ DNA hybridization using biotinylated DNA probes of HPV types 1, 6, 11, 13, 16, 18, and 32. "
5.	Naphthol AS D Esterase (ANAE)IBA 01/01/1983 - "The immunocompetent cells (B and T lymphocytes, mononuclear phagocytes, MPS cells) known to be responsible for the rejection of the HPV- (Human Papillomavirus) induced tumors in the skin (warts) were analyzed in the infiltrates of 63 oral squamous cell lesions of suspected HPV origin (Condyloma, CA; Focal Epithelial Hyperplasia, FEH; Squamous Cell Papilloma, SQP) as well as in tumors thought to be unrelated to HPV (Fibrous Hyperplasia, FH; Papillary Hyperplasia, PH; True Fibroma, TF; Keratoacanthoma, KA), using the ANAE (acid alpha-naphthyl acetate esterase) technique. " 08/01/1984 - "A series of 191 oral mucosal tumors including those with suspected HPV (Human Papilloma Virus) etiology; squamous cell papilloma (SQP), condyloma acuminatum (CA), focal epithelial hyperplasia (FEH), as well as those regarded as unrelated to HPV; fibrous hyperplasia (FH), papillary hyperplasia (PH), and true fibroma (TF), were analyzed for HPV structural proteins (by indirect immunoperoxidase IP-PAP technique), for the presence of epithelial dysplasia, and for the cellular composition (B and T lymphocytes, mononuclear phagocytes, (MPS cells] of their local inflammatory cell infiltrates using ANAE-(acid alpha-naphthyl acetate esterase) stain. "
6.	AcidsIBA 01/01/1983 - "The immunocompetent cells (B and T lymphocytes, mononuclear phagocytes, MPS cells) known to be responsible for the rejection of the HPV- (Human Papillomavirus) induced tumors in the skin (warts) were analyzed in the infiltrates of 63 oral squamous cell lesions of suspected HPV origin (Condyloma, CA; Focal Epithelial Hyperplasia, FEH; Squamous Cell Papilloma, SQP) as well as in tumors thought to be unrelated to HPV (Fibrous Hyperplasia, FH; Papillary Hyperplasia, PH; True Fibroma, TF; Keratoacanthoma, KA), using the ANAE (acid alpha-naphthyl acetate esterase) technique. " 08/01/1984 - "A series of 191 oral mucosal tumors including those with suspected HPV (Human Papilloma Virus) etiology; squamous cell papilloma (SQP), condyloma acuminatum (CA), focal epithelial hyperplasia (FEH), as well as those regarded as unrelated to HPV; fibrous hyperplasia (FH), papillary hyperplasia (PH), and true fibroma (TF), were analyzed for HPV structural proteins (by indirect immunoperoxidase IP-PAP technique), for the presence of epithelial dysplasia, and for the cellular composition (B and T lymphocytes, mononuclear phagocytes, (MPS cells] of their local inflammatory cell infiltrates using ANAE-(acid alpha-naphthyl acetate esterase) stain. "
7.	Papillomavirus Vaccines (HPV Vaccines)IBA 12/01/2015 - "Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine."
8.	Measles-Mumps-Rubella Vaccine (MMR Vaccine)IBA 01/01/2023 - "Intralesional immunotherapy with MMR vaccine in a paediatric case of focal epithelial hyperplasia."
9.	Interferon-betaIBA 05/01/2001 - "We report the successful topical treatment of focal epithelial hyperplasia (Heck's disease) with interferon-beta (Fiblaferon gel). " 05/01/2001 - "Successful topical treatment of focal epithelial hyperplasia (Heck's disease) with interferon-beta."
10.	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 10/01/2004 - "Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia."

Therapies and Procedures

1.	Semiconductor Lasers 05/01/2010 - "We describe a case of focal epithelial hyperplasia in an HIV-seropositive child receiving highly active antiretroviral therapy, who was successfully treated by using diode laser ablation." 02/01/2009 - "Diode Laser therapy for Heck's disease associated with HPV13 infection." 01/01/2022 - "Diode Laser Excision of Focal Epithelial Hyperplasia (Heck's Disease): A Case Report."
2.	Therapeutics 02/01/2009 - "Diode Laser therapy for Heck's disease associated with HPV13 infection." 11/15/1985 - "The clinical, microbiological, histological and electron microscopical findings in cases of oral papillomatosis (Heck's disease, focal epithelial hyperplasia), as well as differential diagnosis and therapy are presented. " 10/20/1976 - "The disorders mentioned include: eczematous processes, rosacea-like dermatitis, steroid rosacea, acne, especially the diagnosis and therapy of cystic acne, psoriasis, atopic dermatitis, viral infection (Heck's disease) and circumscribed scleroderma versus systemic sclerosis and hemiatrophy of the face. "
3.	Gas Lasers 08/01/1990 - "A case of oral focal epithelial hyperplasia (FEH) treated with CO2 laser surgery is presented. " 08/01/1990 - "Oral focal epithelial hyperplasia removed with CO2 laser."
4.	Solid-State Lasers 05/01/2021 - "HPV32-related Heck's disease in a chronic graft-versus-host disease patient with long-term successful KTP laser treatment: A rare case report."
5.	Laser Therapy (Surgery, Laser) 07/16/2014 - "Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery."