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Leukotriene A4

(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Also Known As:
Leukotriene A; Leukotriene A-4; Leukotrienes A; Leukotriene A 4; LTA4
Networked: 57 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Haeggström, Jesper Z: 4 articles (02/2014 - 07/2008)
2. Niegowski, Damian: 2 articles (02/2014 - 01/2014)
3. Kleinschmidt, Thea: 2 articles (02/2014 - 01/2014)
4. Ahmad, Shabbir: 2 articles (02/2014 - 01/2014)
5. Rinaldo-Matthis, Agnes: 2 articles (02/2014 - 01/2014)
6. Cho, Yong-Yeon: 2 articles (12/2010 - 07/2009)
7. Pugliese, Angelo: 2 articles (12/2010 - 07/2009)
8. Bode, Ann M: 2 articles (12/2010 - 07/2009)
9. Jeong, Chul-Ho: 2 articles (12/2010 - 07/2009)
10. Dong, Zigang: 2 articles (12/2010 - 07/2009)

Related Diseases

1. Asthma (Bronchial Asthma)
2. Leukostasis
3. Nephrotic Syndrome (Syndrome, Nephrotic)
4. Inflammation
5. Myocardial Infarction

Related Drugs and Biologics

1. Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
2. Hydroxyeicosatetraenoic Acids (HETE)
3. leukotriene A4 hydrolase
4. Lipoxygenase (Lipoxygenase-1)
5. Diosgenin
6. Leukotriene C4
7. Leukotriene B4
8. Leukotrienes
9. Lipoxins
10. Glutathione (Reduced Glutathione)

Related Therapies and Procedures

1. Balloon Angioplasty