Leukotriene A4
(2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid. An unstable allylic epoxide, formed from the immediate precursor 5-HPETE via the stereospecific removal of a proton at C-10 and dehydration. Its biological actions are determined primarily by its metabolites, i.e., LEUKOTRIENE B4 and cysteinyl-leukotrienes. Alternatively, leukotriene A4 is converted into LEUKOTRIENE C4 by glutathione-S-transferase or into 5,6-di-HETE by the epoxide-hydrolase. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Also Known As:
Leukotriene A; Leukotriene A-4; Leukotrienes A; Leukotriene A 4; LTA4
Networked: 73
relevant articles (3 outcomes,
3 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Haeggström, Jesper Z:
4 articles
(02/2014 - 07/2008)
|
2. | Jeong, Chul-Ho:
3 articles
(11/2018 - 07/2009)
|
3. | Ahmad, Shabbir:
2 articles
(02/2014 - 01/2014)
|
4. | Kleinschmidt, Thea:
2 articles
(02/2014 - 01/2014)
|
5. | Niegowski, Damian:
2 articles
(02/2014 - 01/2014)
|
6. | Rinaldo-Matthis, Agnes:
2 articles
(02/2014 - 01/2014)
|
7. | Bode, Ann M:
2 articles
(12/2010 - 07/2009)
|
8. | Cho, Yong-Yeon:
2 articles
(12/2010 - 07/2009)
|
9. | Dong, Zigang:
2 articles
(12/2010 - 07/2009)
|
10. | Pugliese, Angelo:
2 articles
(12/2010 - 07/2009)
|
Related Diseases
Related Drugs and Biologics
Related Therapies and Procedures