Abdominal Aortic Aneurysm

An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.

Also Known As:

Aortic Aneurysm, Abdominal; Aneurysm, Abdominal Aortic; Abdominal Aorta Aneurysms; Abdominal Aortic Aneurysms; Aorta Aneurysm, Abdominal; Abdominal Aorta Aneurysm; Aneurysm, Abdominal Aorta

Networked: 7278 relevant articles (228 outcomes, 942 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Aneurysm: 24506
    - Aortic Aneurysm: 3427
      - Abdominal Aortic Aneurysm: 7278
        Thoracoabdominal Aortic Aneurysm: 631
        Familial Abdominal 3 Aortic Aneurysm: 14
        Familial Abdominal 1 Aortic Aneurysm
        Familial Abdominal 2 Aortic Aneurysm
  - Aortic Diseases: 879
    - Aortic Aneurysm: 3427
      - Abdominal Aortic Aneurysm: 7278
        Thoracoabdominal Aortic Aneurysm: 631
        Familial Abdominal 3 Aortic Aneurysm: 14
        Familial Abdominal 1 Aortic Aneurysm
        Familial Abdominal 2 Aortic Aneurysm

Related Diseases

1.	Aneurysm (Aneurysms)
2.	Rupture
3.	Aortic Aneurysm (Aneurysm, Aortic)
4.	Endoleak
5.	Inflammation (Inflammations)

Experts

1.	Golledge, Jonathan: 91 articles (01/2022 - 06/2005)
2.	Daugherty, Alan: 62 articles (01/2022 - 03/2003)
3.	Upchurch, Gilbert R: 55 articles (01/2022 - 02/2002)
4.	Dalman, Ronald L: 42 articles (01/2022 - 12/2002)
5.	Lindholt, Jes S: 41 articles (02/2022 - 12/2002)
6.	Schermerhorn, Marc L: 41 articles (01/2022 - 01/2008)
7.	Cassis, Lisa A: 36 articles (01/2022 - 03/2003)
8.	Shi, Guo-Ping: 35 articles (01/2022 - 02/2006)
9.	Norman, Paul E: 35 articles (01/2019 - 03/2007)
10.	Takagi, Hisato: 28 articles (01/2022 - 03/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Abdominal Aortic Aneurysm:

1.	Pancreatic Elastase (Elastase)IBA 05/01/1998 - "The intraluminal elastase perfusion model has been proven to be potentially effective in producing abdominal aortic aneurysms (AAA) in rodents, yet has produced unpredictable results in larger animals. " 05/01/1997 - "The intraluminal elastase perfusion model has been proved to be potentially effective in producing abdominal aortic aneurysm in rodents, but it produced unpredictable results in larger animals. " 05/01/2023 - "The present study aimed to explore the impact of porcine pancreatic elastase (PPE) perfusion pressure on the morphology of abdominal aortic aneurysms. " 01/01/2023 - "Our previous studies showed that adult human bone marrow mesenchymal stem cell (BM-MSC)-derived EVs provide antiproteolytic and proregenerative effects in cultures of smooth muscle cells (SMCs) derived from an elastase-infused rat abdominal aortic aneurysm (AAA) model, and this is promising toward their use as a therapeutic platform for naturally irreversible elastic matrix aberrations in the aortic wall. " 10/08/2022 - "The study established an elastase-induced mouse abdominal aortic aneurysms model as well as a TNF-α-mediated vascular smooth muscle cells (VSMCs) model, respectively. "
2.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/01/2022 - "The necessity and efficacy of statin treatment for abdominal aortic aneurysm (AAA) remains controversial. " 05/29/2023 - "Role of Statins after Endovascular Repair of Abdominal Aortic Aneurysms: A Nationwide Population-Based Study." 12/01/2018 - "The aim of this study was to evaluate the association between perioperative statin intensity and in-hospital mortality following open abdominal aortic aneurysm (AAA) repair. " 06/01/2013 - "Observational studies in human patients and animal experiments suggested that statins have a potential in slowing the growth of small abdominal aortic aneurysms (AAA). " 12/01/2011 - "The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). "
3.	Telmisartan (Micardis)FDA Link 12/01/2020 - "Efficacy of Telmisartan to Slow Growth of Small Abdominal Aortic Aneurysms: A Randomized Clinical Trial." 10/01/2022 - "This study was an unplanned exploratory analysis of a subset of participants from the Telmisartan in the Management of Abdominal Aortic Aneurysm (TEDY) trial. " 01/01/2022 - "Patients with an AAA measuring 35 - 49 mm in maximum diameter were recruited as part of the TElmisartan in the management of abdominal aortic aneurysm (TEDY) trial. " 01/20/2016 - "Erratum to: 'TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial'." 06/17/2015 - "Telmisartan in the management of abdominal aortic aneurysm (TEDY) is a multicentre, parallel-design, randomised, double-blind, placebo-controlled trial with an intention-to-treat analysis. "
4.	Metformin (Glucophage)FDA LinkGeneric 01/01/2023 - "Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms." 12/27/2021 - "Multiple observational studies have associated metformin prescription with reduced progression of abdominal aortic aneurysm (AAA). " 01/01/2021 - "Future clinical trials using metformin are warranted in patients without diabetes with abdominal aortic aneurysms." 01/01/2021 - "Metformin to Limit Abdominal Aortic Aneurysm Expansion: Time for Clinical Trials." 01/01/2021 - "The Metformin for Abdominal Aortic Aneurysm Growth Inhibition (MAAAGI) Trial."
5.	Anesthetics (Anesthetic Agents)IBA 06/01/1986 - "Improvement in anesthetic and surgical techniques has prompted a more aggressive approach to repair of abdominal aortic aneurysms in patients more than 80 years old. " 12/01/2022 - "Anesthetic Management for Endovascular Repair of Thoracic and Abdominal Aortic Aneurysms." 12/01/2022 - "Anesthetic Management for Open Thoracoabdominal and Abdominal Aortic Aneurysm Repair." 10/01/2022 - "In the endovascular treatment of ruptured abdominal aortic aneurysm (RAAA), there is no effective evidence to show preference for a specific anesthetic option. " 01/01/2020 - "During abdominal aortic aneurysm surgery anesthetic challenge is also of paramount importance and should be considered."
6.	Biomarkers (Surrogate Marker)IBA 01/01/2020 - "Identifying biomarkers for abdominal aortic aneurysms (AAA) could prove beneficial in prognosis of AAA and thus the selection for treatment. " 10/01/2010 - "Identification of biomarkers for the natural history of abdominal aortic aneurysms (AAA) holds the key to non-surgical intervention and improved selection for AAA repair. " 01/01/2023 - "The purpose of this study was to employ biomechanics-based biomarkers to locally characterize abdominal aortic aneurysm (AAA) tissue and investigate their relation to local aortic growth by means of an artificial intelligence model. " 06/01/2022 - "Overall, this study provides experimental evidence that hsa_circ_0087352 can be used as a new biomarker and therapeutic target for abdominal aortic aneurysm." 04/16/2021 - "Studies reporting on humans, on abdominal aortic aneurysm growth rates and on serum circulating biomarkers were included. "
7.	CytokinesIBA 06/01/2020 - "This study compares the effect of Helicobacter (H.) pylori and Lactobacillus (L.) acidophilus on the cytokine profile of PBMCs of 5 men with abdominal aortic aneurysm (AAA) and 5 men with normal/insignificant angiography, CT-Scan and ultrasonography results in the single-culture and in the co-culture with HUVECs. " 01/01/2018 - "The purpose of our study was to identify differential cytokine expression in patients with abdominal aortic aneurysm and those with atherosclerotic occlusive disease. " 11/01/2012 - "The aim of this study was to evaluate alterations in Th1 and Th2 cytokines during experimental abdominal aortic aneurysm (AAA) formation. " 05/01/2010 - "The aim of this study was to examine aortic biopsies with a cytokine array to identify new cytokines associated with abdominal aortic aneurysm (AAA). " 09/01/2004 - "The aims of this study were to determine if cytokines or their genetic polymorphisms were related to outcome after abdominal aortic aneurysm (AAA) repair. "
8.	Matrix Metalloproteinases (MMPs)IBA 07/01/2007 - "Basic and clinical studies have revealed a strong correlation between matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, and the formation of abdominal aortic aneurysms. " 10/01/1998 - "An earlier study from our laboratory showed differences in matrix metalloproteinase expression patterns in cultures of medial smooth muscle cells from tissue affected by abdominal aortic aneurysm (AAA) or atherosclerotic occlusive disease and from normal arterial tissue. " 01/01/2023 - "Matrix metalloproteinases (MMPs) play a key role in the pathogenesis of abdominal aortic aneurysm (AAA). " 01/01/2023 - "Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm." 01/01/2023 - "Matrix metalloproteinase (MMP)-12 is highly expressed in abdominal aortic aneurysms and its elastolytic function has been implicated in the pathogenesis. "
9.	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 05/01/1996 - "The authors report the experience of a single investigational center involving two Phase I and a Phase II clinical trials approved by the Food and Drug Administration (FDA) for the transfemoral implantation of woven Dacron grafts for abdominal aortic aneurysms. " 08/01/2023 - "The patient had an aorto bi-iliac synthetic dacron graft repair of an abdominal aortic aneurysm (AAA) some 20 years ago. " 04/01/2021 - "Patient A was an 84-year-old man with prior abdominal aortic aneurysm open repair with a straight 20 mm Dacron tube. " 01/01/2020 - "Here we report a case of infra-renal abdominal aortic aneurysm (AAA) of diameter 6 cm. The patient sucessfully underwent aorto-biiliac bypass surgery using Dacron Y graft. " 01/01/2016 - "The abdominal aortic aneurysm was replaced using a Hemashield Dacron bifurcated 14 mm x 7 mm bypass graft. "
10.	Heparin (Liquaemin)FDA LinkGeneric 08/01/1990 - "Clinical application of heparin surface coated equipment during resection of thoraco-abdominal aortic aneurysms is showing promising results in 12 patients." 09/19/2021 - "Soon the recruitment will start in Germany Health condition(s) or problem(s) studied Abdominal aortic aneurysm, arterial disease, surgery Intervention(s) ACT-guided heparinization 5000 IU of heparin Key inclusion and exclusion criteria Ages eligible for the study: ≥18 years Sexes eligible for the study: both Accepts healthy volunteers: no Inclusion criteria: Study type Interventional Allocation: randomized Intervention model: parallel assignment Masking: single blind (patient) Primary purpose: treatment Phase IV Date of first enrolment March 2020 Target sample size 750 Recruitment status Recruiting Primary outcome(s) The primary efficacy endpoint is 30-day mortality and in-hospital mortality during the same admission. " 10/01/2023 - "Systemic administration of heparin is widely used in patients undergoing open elective abdominal aortic aneurysm (AAA) repair. " 10/01/2023 - "The Impact of Heparin on Mortality Following Open Ruptured Abdominal Aortic Aneurysm Repair." 08/19/2016 - "The primary objective was to assess the effect of intravenous heparin on all-cause mortality in ruptured abdominal aortic aneurysm (rAAA) management in people undergoing an emergency repair.The"

Therapies and Procedures

1.	Endovascular Aneurysm Repair 10/31/2023 - "While endovascular aneurysm repair has become a first-line strategy in many centers, open surgical repair (OSR) of abdominal aortic aneurysms (AAAs) is still the best option for certain patients. " 05/01/2013 - "The recent Anévrisme de l'aorte abdominale: Chirurgie versus Endoprothèse (ACE) study showed that open surgery of infrarenal abdominal aortic aneurysms (AAAs) provided very good results in patients with standard surgical risk, with good anatomic results for endovascular aneurysm repair (EVAR). " 10/01/2018 - "Recent study have demonstrated the good results of endovascular aneurysm repair (EVAR) for ruptured abdominal aortic aneurysms (RAAAs). " 01/01/2022 - "Endovascular aneurysm repair (EVAR) is often seen as the first choice treatment for patients with abdominal aortic aneurysm (AAA), particularly high-risk patients, yet the long-term survival rate and improvement in quality of life are still unclear. " 01/01/2019 - "Significant research efforts have been made to improve the safety and efficacy of endovascular aneurysm repair (EVAR) in treating abdominal aortic aneurysm. "
2.	Stents 01/01/2021 - "Our experience showed high safety and efficacy of stent graft implantation in treatment of patients with abdominal aortic aneurysms and high surgical risk. " 11/01/2015 - "The aim was to determine whether physician modified stent grafts (PMSGs) are safe and effective for the treatment of high risk patients with thoraco-abdominal aortic aneurysms (TAAAs). " 10/01/2012 - "The use of Endurant stent-graft for abdominal aortic aneurysm: the story about extension of instruction for use with persistent good results of stent-graft latest generation." 05/01/2006 - "Whilst the overall management of abdominal aortic aneurysms has undoubtedly benefited from the introduction of stent-grafts, open repair currently remains the gold standard treatment." 10/01/2011 - "The initial experience shows that the Sandwich technique with the Aorfix™ stent-graft demonstrated to be effective in endovascular repair of abdominal aortic aneurysms in patients with aortoiliac anatomy hostile to preserving hypogastric artery patency. "
3.	Therapeutics 01/01/2019 - "Identification of a safe and effective medical therapy for abdominal aortic aneurysm (AAA) disease remains a significant unmet medical need. " 01/01/2016 - "We report an abdominal aortic aneurysm infected with Helicobacter cinaedi, treated successfully with surgical repair and long-term antimicrobial therapy. " 01/01/2021 - "Currently, no medical therapy is effective in limiting progression of small abdominal aortic aneurysms (AAA; ≤5.5 cm). " 01/01/2019 - "Abdominal aortic aneurysm (AAA) is a degenerative disease affecting human health, but there are no safe and effective medications for AAA therapy. " 03/01/2007 - "The study was conducted to demonstrate improved survival (30-day mortality) after the introduction of an emergency endovascular therapy protocol for ruptured abdominal aortic aneurysms (rAAA). "
4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 09/01/2003 - "This experience suggests that combined coronary artery bypass grafting and abdominal aortic aneurysm repair is both safe and effective." 08/01/2014 - "We reviewed the literature for studies investigating the outcomes of combined 1-stage coronary artery bypass grafting (CABG) and abdominal aortic aneurysm (AAA) open repair (OR) procedures. " 03/01/1999 - "The purpose of this study was to examine the relationship between hospital volume and in-hospital deaths in 3 cardiovascular procedures: coronary artery bypass grafting, elective repair of abdominal aortic aneurysms, and repair of congenital cardiac defects. " 11/11/2022 - "In this report, we present an unusual case of undergoing simultaneous open abdominal aortic aneurysm (AAA) repair and coronary artery bypass grafting (CABG). " 04/01/2021 - "We retrieved data from 2001 to 2014 for patients who had undergone abdominal aortic aneurysm (AAA) repair, coronary artery bypass graft, or aortic valve replacement (AVR). "
5.	Endovascular Procedures 09/01/2016 - "Open surgical repair has been seen as the gold standard treatment for juxtarenal abdominal aortic aneurysm; however, endovascular techniques are now becoming more prevalent, particularly in patients deemed high risk for morbidity and mortality with open repair. " 01/01/2023 - "The AFX2 endograft combined with a proximal thoracic aortic cuff plays a safe and effective role in treating complex infrarenal abdominal aortic aneurysm that may otherwise be technically more challenging with the open technique and inaccessible with the traditional endovascular technique." 05/01/2010 - "This article will review the endovascular management of ruptured abdominal aortic aneurysms and describe the endovascular techniques for safe and effective treatment. " 12/01/2020 - "The development of endovascular techniques has improved abdominal aortic aneurysm (AAA) management over the past 2 decades. " 12/01/2023 - "What we have learned from in-vitro studies of the chimney endovascular technique for treatment of complex abdominal aortic aneurysms: A systematic review."