Ruptured Aneurysm

The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.

Also Known As:

Networked: 841 relevant articles (47 outcomes, 61 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aneurysm (Aneurysms)
2.	Intracranial Aneurysm (Cerebral Aneurysm)
3.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
4.	Intracranial Vasospasm
5.	Hemorrhage

Experts

1.	Jabbour, Pascal: 10 articles (01/2021 - 08/2012)
2.	Hong, Bo: 9 articles (08/2021 - 05/2012)
3.	Xu, Yi: 8 articles (08/2021 - 05/2012)
4.	Lawton, Michael T: 7 articles (11/2021 - 10/2010)
5.	Hoh, Brian L: 7 articles (03/2019 - 06/2002)
6.	Starke, Robert M: 6 articles (10/2022 - 08/2012)
7.	Hasan, David: 6 articles (01/2020 - 04/2011)
8.	Chalouhi, Nohra: 6 articles (06/2017 - 08/2012)
9.	Liu, Jian-Min: 6 articles (08/2014 - 05/2012)
10.	Sauvageau, Eric: 5 articles (06/2021 - 12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ruptured Aneurysm:

1.	Tirofiban (Aggrastat)FDA Link 08/01/2021 - "This study evaluated the safety and efficacy of reducing the dosage of tirofiban for the ruptured aneurysms with SAC. " 10/01/2012 - "We assessed the efficacy and safety of IA tirofiban infusion in patients with ruptured aneurysms. " 08/01/2019 - "Between April 2016 and January 2018, 12 consecutive coil protrusions that occurred during ruptured aneurysms' embolizations were rescued using NA stenting together with tirofiban therapy. " 01/01/2020 - "In Reply: The Safety and Efficacy of Continuous Tirofiban as a Monoantiplatelet Therapy in the Management of Ruptured Aneurysms Treated Using Stent-Assisted Coiling or Flow Diversion and Requiring Ventricular Drainage." 01/01/2020 - "Letter: The Safety and Efficacy of Continuous Tirofiban as a Monoantiplatelet Therapy in the Management of Ruptured Aneurysms Treated Using Stent-Assisted Coiling or Flow Diversion and Requiring Ventricular Drainage."
2.	Nimodipine (Modus)FDA LinkGeneric 01/01/2022 - "However, despite the number of publications, the only treatments shown to be effective in adequate, well-controlled clinical trials are nimodipine and repair of the ruptured aneurysm. " 06/01/1989 - "The efficacy of intravenous Nimodipine (used at the rate of 2 mg.h-1) was investigated in the treatment of delayed ischemic deterioration or angiographic vasospasm after subarachnoid haemorrhage caused by a ruptured aneurysm in a randomized, double-blind, placebo-controlled multicenter study. " 10/01/1999 - "One hundred twenty-seven patients of both sexes who had a ruptured aneurysm (verified using angiography), who presented with Hunt and Hess Grades I to III on admission, who underwent an operation within the first week after SAH, and who had participated in a randomized prospective clinical trial of nimodipine medication were enrolled in the study. " 07/07/2020 - "Early strategy of scepter XC balloon angioplasty and simultaneous Nimodipine infusion for vasospasm following ruptured aneurysm." 02/01/2008 - "In this small series, extended intra-arterial infusion of nimodipine up to the end of the embolization procedure was effective and safe in patients with a ruptured aneurysm and associated vasospasm. "
3.	Antifibrinolytic Agents (Antifibrinolytics)IBA 08/01/1975 - "The antifibrinolytic treatment definitely lessened the incidence of rebleeding of the ruptured aneurysms during waiting time for surgery, and there were no noticeable complications following this treatment. " 07/01/1992 - "The value of the antifibrinolytic treatment was assessed in two groups od patients treated after subarachnoid haemorrhage from ruptured aneurysm. " 02/01/1997 - "When early surgical intervention became routine for ruptured aneurysms, the use of antifibrinolytic therapy diminished. " 06/01/2011 - "Antifibrinolytic drugs in subarachnoid hemorrhage by ruptured aneurysms." 01/01/1979 - "With regard to the higher risk of severe vasospasm and occlusion of cerebral arteries in our opinion it should not be a therapeutic goal to try to achieve a thrombosis of a ruptured aneurysm with antifibrinolytic drugs. "
4.	HydrogelsIBA 04/01/2017 - "Our data show that the use of the newer-generation hydrogel coils in the treatment of ruptured aneurysms is feasible, safe and effective with high immediate and mid-term occlusion rates and low morbidity." 04/01/2017 - "A multicenter retrospective study was carried out of angiographic and clinical outcome data on consecutive patients with ruptured aneurysms treated with at least 70% of the newer generation of hydrogel coils. " 04/01/2017 - "To assess the 'real-world' performance of the newer generation of hydrogel coils in ruptured aneurysms. " 04/01/2017 - "Safety, immediate and mid-term results of the newer generation of hydrogel coils in the treatment of ruptured aneurysms: a multicenter study." 05/14/2011 - "In a prespecified subgroup analysis in recently ruptured aneurysms, there were more adverse composite primary outcomes in the control group than in the hydrogel group-OR 2·08 (1·24-3·46, p=0·014). "
5.	Heparin (Liquaemin)FDA LinkGeneric 08/01/2016 - "However, over the last 5 years, I have also utilized a novel treatment strategy, originally developed at the University of Maryland, which consists of a 14-day continuous low-dose intravenous heparin infusion (LDIVH) beginning 12 h after securing the ruptured aneurysm. " 04/01/2012 - "This diathesis may respond well to heparin administration, suggesting that heparin administration in ruptured aneurysms is appropriate." 02/01/2015 - "Group 2 consisted of 100 previous patients with ruptured aneurysm managed with coil embolization who had received heparin and/or aspirin at the beginning of the procedure. "
6.	SteroidsIBA 05/01/2001 - "Although surgical treatment is the first choice for ruptured aneurysms, steroid therapy may be effective for unruptured small aneurysms in patients with Behçet's disease." 01/01/1993 - "The 2-CDA treatment was started immediately after angiographic confirmation of ruptured aneurysm, and the standard pharmacological treatment (nimodipine and steroids) was also given. "
7.	Serum AlbuminIBA 06/01/2007 - "Patients with a ruptured aneurysm had a significantly greater level of CRP, higher WBC, and lower serum albumin than those with an asymptomatic intact aneurysm. " 01/01/2018 - "Univariable and multivariable logistic regression analyses were performed to determine the association between serum albumin-corrected total calcium and magnesium levels and ruptured aneurysms. "
8.	Intravenous AnestheticsIBA 01/01/2022 - "Our data suggest that those who received inhalational versus intravenous anesthetic for ruptured aneurysm repair had significant protection against SAH-induced angiographic vasospasm and DCI. "
9.	Propofol (Diprivan)FDA LinkGeneric 10/01/2000 - "In multivariate analysis of patients with ruptured aneurysms, younger age, better clinical grade, lower maximum systolic intraoperative blood pressure, shorter duration of surgery, and use of propofol were independently associated with better outcome. " 10/01/2000 - "Multivariate analysis of intraoperative factors affecting outcome in patients undergoing craniotomy for ruptured aneurysms shows that decreased intraoperative blood pressure and use of propofol are associated with improved outcome. " 10/01/2000 - "In univariate analysis of patients with ruptured aneurysms, younger age, better clinical grade, lower Fisher grade, lower intraoperative blood pressure (maximum systolic and mean blood pressure), smaller decrease in intraoperative compared to preoperative systolic blood pressure, shorter duration of surgery, and use of propofol, pancuronium, or N(2)O were associated with significantly better outcome. "
10.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 06/01/2006 - "We examined prospectively the efficacy of arachnoid plasty using fibrin glue membrane during surgery of ruptured aneurysms in the elderly patients for preventing complications. " 06/01/2006 - "Effect of arachnoid plasty using fibrin glue membrane after clipping of ruptured aneurysm on the occurrence of complications and outcome in the elderly patients."

Therapies and Procedures

1.	Therapeutics 12/01/2022 - "In some cases, at least for factors that do not result in significant difficulty for endovascular therapy, such as the presence of an en passage artery or ruptured aneurysm, endovascular therapy can be considered to be as safe and effective as clipping." 01/01/2023 - "FD insertion combined with coil embolization is a potentially safe and effective therapeutic strategy for ruptured aneurysms when accompanied with perioperative evidence-based antithrombotic therapy." 02/01/2012 - "Intracisternal MgSO(4) therapy using a microcatheter from the lumbar spine may be effective against vasospasm in the clinical setting of endovascular treatment of ruptured aneurysm." 10/01/2020 - "Purpose of this study is to evaluate the safety and efficacy of p48 and p64 MW HPC with single antiplatelet therapy for the acute treatment of ruptured aneurysm. " 11/01/2023 - "In the multivariate analysis the patients who came with a ruptured aneurysm and patients who needed secondary therapy in the first 30 days more often did not comply with the FU protocol (P = .03 and P < .01). "
2.	Stents 03/01/2006 - "The ruptured aneurysm was confirmed by performing computed tomography and digital angiography and thereafter was successfully repaired by endovascular stenting technique (Talent stent-graft), which seems to be a safe and effective method of preserving a renal graft." 01/01/2018 - "When coiling or microsurgical clipping are not feasible strategies, anterior circulation ruptured aneurysms can be effectively treated with a flow-diversion technique, minimizing the number of stents deployed. " 10/01/2020 - "The LVIS stent-assisted coiling may be safe and effective in the treatment of selected patients with ruptured aneurysms within 24 h of symptom onset." 09/01/2016 - "WEB treatment of small ruptured aneurysms was safe and effective without the need for anticoagulation, adjunctive stents, or balloons. " 10/01/2020 - "We aimed to investigate the safety and efficacy of the Low Profile Visualized Intraluminal Support (LVIS) stent for ruptured aneurysms treatment within 24 h comparing to the treatment between 25 and 72 h of symptom onset. "
3.	Endovascular Procedures 01/01/2007 - "Since then, a less invasive endovascular technique has been found effective in a trial of ruptured aneurysms. " 07/01/2014 - "Treatment of patients with ruptured aneurysm by neurosurgeons that perform both open surgical and endovascular techniques is safe and effective: results of a single centre in Europe." 05/01/2007 - "We reviewed the medical records, radiographical studies and endovascular procedures to evaluate the morbidity and mortality related to ruptured aneurysm coiling. " 08/01/2023 - "Surgical repair of ruptured aneurysms costs less and requires less instrumentation compared with endovascular procedures. " 10/01/2022 - "Most patients had previously ruptured aneurysms, treated by another endovascular technique. "
4.	Surgical Instruments (Clip) 07/05/2016 - "The aneurysms ruptured during predissection in 2 cases (10.5%), during dissection in 11 cases (57.9%) and during clip application in 6 cases (31.6%). " 02/01/2015 - "Propensity score matching was used to adjust the differences in age, sex, modified Fisher grade, World Federation of Neurosurgical Societies (WFNS) clinical grade at admission, size and location of a ruptured aneurysm, treatment modality (clip placement vs coil embolization), and time interval from SAH to admission between the two time periods. " 01/01/2015 - "These cases should be informative as they show extremely long-term course of a clip applied for a ruptured aneurysm." 02/01/2013 - "For ruptured aneurysms, there was a statistically significant difference in clipping and coiling with respect to age and treatment modality (clip 48.8 years, coil 57.6 years). " 02/01/2010 - "In the last four years, 9 cases of ruptured aneurysms treated by the clip-wrap techniques were identified in the Division of Neurological Surgery, University of São Paulo, School of Medicine. "
5.	Endovascular Aneurysm Repair 12/01/2020 - "Emergent TEVAR for the repair of ruptured aneurysm has demonstrated improved perioperative mortality and morbidity compared to traditional open repair. " 11/01/2019 - "Recent development of thoracic endovascular repair has contributed to improved outcomes for the treatment of ruptured aneurysm of the thoracic aorta. " 03/31/2023 - "Here, we report our experience of performing this add-on embolization procedure after endovascular aneurysm repair for complex ruptured aneurysms of the aortoiliac segment. " 08/01/2016 - "To evaluate the differences in technical outcomes and secondary interventions between elective endovascular aneurysm repair (el-EVAR) procedures and those for ruptured aneurysms (r-EVAR). " 02/01/2014 - "IMPROVE is a pragmatic, multicentre randomized clinical trial in which eligible patients with a clinical diagnosis of ruptured aneurysm were allocated to a strategy of endovascular aneurysm repair (EVAR) or to open repair. "