|1.||Koeberl, Dwight D: 4 articles (05/2014 - 11/2010)|
|2.||Scott, Carolyn D: 3 articles (12/2013 - 11/2002)|
|3.||Li, Songtao: 3 articles (01/2013 - 11/2010)|
|4.||Sun, Baodong: 3 articles (01/2013 - 11/2010)|
|5.||Zavras, Athanasios I: 3 articles (06/2012 - 01/2003)|
|6.||Huang, Chih-Yang: 3 articles (06/2009 - 08/2006)|
|7.||Chu, Chun-Hsien: 3 articles (06/2009 - 08/2006)|
|8.||Kuo, Wei-Wen: 3 articles (06/2009 - 08/2006)|
|9.||Jeanjean, Audrey: 2 articles (05/2015 - 05/2006)|
|10.||Morère, Alain: 2 articles (05/2015 - 05/2006)|
|1.||Glycogen Storage Disease Type II (Pompe's Disease)
11/01/2010 - "Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease."
06/01/2011 - "Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle."
05/01/2014 - "Effective dosages for enzyme replacement therapy (ERT) in Pompe disease are much higher than for other lysosomal storage disorders, which has been attributed to low cation-independent mannose-6-phosphate receptor (CI-MPR) in skeletal muscle. "
01/01/2008 - "Abnormal mannose-6-phosphate receptor trafficking impairs recombinant alpha-glucosidase uptake in Pompe disease fibroblasts."
01/01/2013 - "Pompe disease has resisted enzyme replacement therapy with acid α-glucosidase (GAA), which has been attributed to inefficient cation-independent mannose-6-phosphate receptor (CI-MPR) mediated uptake. "
11/01/2012 - "This effect was mediated by transient but dramatic upregulation of the mannose-6-phosphate receptor (MPR) on the tumor cell surface. "
06/01/2012 - "Insulin-like growth factor II receptor (IGF2R) degrades mitogen and hence is associated with tumor suppressor function. "
02/08/2008 - "Normal function of insulin-like growth factor II receptor (IGF2R) gene has been associated with negative control of tumor growth in vivo and in vitro. "
05/01/2004 - "The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?"
04/01/2001 - "The insulin-like growth factor-II receptor (IGF-IIR) is frequently mutated or deleted in some malignant human tumors, suggesting that the IGF-IIR is a tumor suppressor. "
01/01/1994 - "Analysis of the IGF-II receptor gene copy number in breast carcinoma."
01/01/1994 - "In order to determine whether the Man-6-P/IGF-II receptor gene copy number is altered in breast cancer we analysed specimens of invasive breast carcinoma from 51 patients by Southern blotting. "
03/01/2003 - "Mannose-6-phosphate/insulin-like growth factor-II receptor expression levels during the progression from normal human mammary tissue to invasive breast carcinomas."
02/01/2003 - "Oxidative damage was investigated on the two genes in gastric mucosal tissue infected with Helicobacter pylori, which were genes of glyceraldehydes-3-phosphate dehydrogenase (GAPDH), a house-keeping gene, and gene of insulin-like growth factor II receptor (IGFIIR), a gene known to be mutated frequently in gastric carcinoma. "
02/15/2000 - "Stable amino-acid sequence of the mannose-6-phosphate/insulin-like growth-factor-II receptor in ovarian carcinomas with loss of heterozygosity and in breast-cancer cell lines."
|4.||Hepatocellular Carcinoma (Hepatoma)
06/01/2003 - "It was reported that 60-70% of hepatitis B virus (HBV)-negative hepatocellular carcinoma (HCC) had loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus and this gene was mutated in 55% of these patients with LOH. "
06/01/2003 - "Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma."
05/01/2002 - "Mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) tumor suppressor- gene mutation is an early event in human hepatocellular carcinoma (HCC) formation in the United States, but its role in hepatocarcinogenesis in Japan is unclear. "
11/01/1987 - "These results indicate that the IGF-II receptor mediates a particular biological response--stimulation of glycogen synthesis in hepatoma cells. "
08/01/1995 - "Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma."
|5.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2001 - "Microsatellite Analysis of the Insulin-Like Growth Factor II Receptor in Colorectal Carcinomas."
07/15/1999 - "Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells."
01/01/2015 - "The aim of this study was to investigate the expression of IGF-2 after 5-aminolevulinic acid (5-ALA)-mediated-PDT in SW620 human colorectal cancer cells with evaluation of cell proliferation and apoptosis and to determine the effects of PDT on the IGF-2 receptor (IGF-2R), IGF-2 binding protein-1 (IGF-2BP-1) and the proapoptotic protein, BAX. "
10/01/2000 - "Eighty-six regions from 16 MSI-positive sporadic colorectal carcinomas were examined for mutations in repeat nucleotide sequences of the tumour suppressor genes transforming growth factor beta type II receptor (TGFBRII), insulin-like growth factor II receptor (IGFIIR), and BAX, and the mismatch repair genes MSH3 and MSH6. "
04/01/2000 - "About 15% of sporadic colorectal carcinomas arise via a mechanism associated with microsatellite instability (MSI) and mutations in transforming growth factor beta receptor II (TGFbetaRII), insulin-like growth factor II receptor (IGFIIR) and BAX, whilst the remaining 85% are associated with aneuploidy and gross chromosomal rearrangements. "
|1.||Insulin-Like Growth Factor II (Somatomedin A)
|2.||Insulin-Like Growth Factor I (IGF-1)
|6.||Transforming Growth Factor beta (TGF-beta)
|7.||IGF Type 1 Receptor (IGF 1 Receptor)
|8.||Transforming Growth Factor beta1 (TGF beta 1)
|10.||RNA (Ribonucleic Acid)
|1.||Enzyme Replacement Therapy
|2.||Drug Therapy (Chemotherapy)
|4.||Heart Transplantation (Grafting, Heart)