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IGF Type 1 Receptor (IGF 1 Receptor)

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Also Known As:
IGF 1 Receptor; Receptor, IGF Type 1; IGF-1 Receptor; Insulin-Like-Growth Factor I Receptor; Receptor, IGF Type 1 alpha Subunit; Receptor, IGF Type 1 beta Subunit; Receptors, IGF-1; Receptors, Insulin-Like-Growth Factor I; IGF I Receptor; IGF-1 Receptors; Insulin Like Growth Factor I Receptor; Receptor, IGF I; Receptor, IGF-1; Receptors, IGF 1; IGF-I Receptor; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor I; Receptor, Insulin-Like Growth Factor Type 1
Networked: 1244 relevant articles (25 outcomes, 145 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Werner, Haim: 25 articles (01/2013 - 04/2003)
2. Belfiore, Antonino: 16 articles (01/2017 - 11/2002)
3. Smith, Terry J: 15 articles (01/2022 - 06/2003)
4. Adachi, Yasushi: 13 articles (02/2014 - 10/2002)
5. LeRoith, Derek: 13 articles (10/2013 - 06/2003)
6. Pollak, Michael: 12 articles (12/2018 - 12/2002)
7. Carbone, David P: 11 articles (02/2014 - 10/2002)
8. Imai, Kohzoh: 11 articles (02/2014 - 10/2003)
9. Yamamoto, Hiroyuki: 11 articles (02/2014 - 10/2003)
10. Vigneri, Riccardo: 10 articles (06/2015 - 11/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Inflammation (Inflammations)
3. Carcinoma (Carcinomatosis)
4. Insulin Resistance
5. Graves Ophthalmopathy

Related Drugs and Biologics

1. Insulin-Like Growth Factor I (IGF-1)
2. Insulin Receptor
3. teprotumumab
4. Insulin-Like Peptides
5. Insulin (Novolin)
6. Monoclonal Antibodies
7. Intercellular Signaling Peptides and Proteins (Growth Factors)
8. Antibodies
9. Ligands
10. Metformin (Glucophage)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Electroacupuncture
4. Surgical Instruments (Clip)
5. Castration