A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Also Known As:
IGF 1 Receptor; Receptor, IGF Type 1; IGF-1 Receptor; Insulin-Like-Growth Factor I Receptor; Receptor, IGF Type 1 alpha Subunit; Receptor, IGF Type 1 beta Subunit; Receptors, IGF-1; Receptors, Insulin-Like-Growth Factor I; IGF I Receptor; IGF-1 Receptors; Insulin Like Growth Factor I Receptor; Receptor, IGF I; Receptor, IGF-1; Receptors, IGF 1; IGF-I Receptor; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor I; Receptor, Insulin-Like Growth Factor Type 1