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IGF Type 1 Receptor (IGF 1 Receptor)

A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Also Known As:
IGF 1 Receptor; Receptor, IGF Type 1; IGF-1 Receptor; Insulin-Like-Growth Factor I Receptor; Receptor, IGF Type 1 alpha Subunit; Receptor, IGF Type 1 beta Subunit; Receptors, IGF-1; Receptors, Insulin-Like-Growth Factor I; IGF I Receptor; IGF-1 Receptors; Insulin Like Growth Factor I Receptor; Receptor, IGF I; Receptor, IGF-1; Receptors, IGF 1; IGF-I Receptor; Receptor, IGF-I; Receptor, Insulin-Like Growth Factor I; Receptor, Insulin-Like Growth Factor Type 1
Networked: 963 relevant articles (11 outcomes, 106 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Werner, Haim: 26 articles (01/2013 - 04/2003)
2. Belfiore, Antonino: 14 articles (06/2015 - 11/2002)
3. Adachi, Yasushi: 12 articles (02/2014 - 10/2002)
4. Carbone, David P: 11 articles (02/2014 - 10/2002)
5. Pollak, Michael: 11 articles (01/2013 - 12/2002)
6. Vigneri, Riccardo: 10 articles (06/2015 - 11/2002)
7. Yamamoto, Hiroyuki: 10 articles (02/2014 - 10/2003)
8. Imai, Kohzoh: 10 articles (02/2014 - 10/2003)
9. LeRoith, Derek: 10 articles (10/2013 - 06/2003)
10. Sarfstein, Rive: 10 articles (01/2013 - 08/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinoma (Carcinomatosis)
3. Osteosarcoma (Osteogenic Sarcoma)
4. Lung Neoplasms (Lung Cancer)
5. Lung Injury

Related Drugs and Biologics

1. Insulin-Like Growth Factor I (IGF-1)
2. Insulin (Novolin)
3. Insulin Receptor
4. Antibodies
5. Carbon Monoxide
6. 3- (8- amino- 1- (2- phenylquinolin- 7- yl)imidazo(1,5- a)pyrazin- 3- yl)- 1- methylcyclobutanol
7. Fibrinogen (Factor I)
8. Antirheumatic Agents (DMARD)
9. indium-bleomycin
10. Insulin-Like Growth Factor II (Somatomedin A)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Surgical Instruments (Clip)
3. Heterologous Transplantation (Xenotransplantation)
4. Radiotherapy
5. Antineoplastic Protocols