|1.||Werner, Haim: 26 articles (01/2013 - 04/2003)|
|2.||Belfiore, Antonino: 14 articles (06/2015 - 11/2002)|
|3.||Adachi, Yasushi: 12 articles (02/2014 - 10/2002)|
|4.||Carbone, David P: 11 articles (02/2014 - 10/2002)|
|5.||Pollak, Michael: 11 articles (01/2013 - 12/2002)|
|6.||Vigneri, Riccardo: 10 articles (06/2015 - 11/2002)|
|7.||Yamamoto, Hiroyuki: 10 articles (02/2014 - 10/2003)|
|8.||Imai, Kohzoh: 10 articles (02/2014 - 10/2003)|
|9.||LeRoith, Derek: 10 articles (10/2013 - 06/2003)|
|10.||Sarfstein, Rive: 10 articles (01/2013 - 08/2005)|
08/15/2009 - "Therapeutic strategies that target the insulin-like growth factor I receptor (IGF-1R) hold promise for a wide variety of cancers. "
01/01/2014 - "Recent studies have shown that targeting of the IGF-1 receptor (IGF-1R) signaling pathway might be a novel approach for the treatment of cancer. "
01/01/2012 - "These studies, combined with data that link alterations in the levels of circulating IGFs with cancer risk and prognosis, have focused on the IGF-1 receptor (IGF-1R) as a therapeutic target for patients with cancer. "
02/01/2011 - "Pharmacokinetically guided phase 1 trial of the IGF-1 receptor antagonist RG1507 in children with recurrent or refractory solid tumors."
02/01/2009 - "Although studies have clearly demonstrated the transforming potential of both GH and IGF-I receptor in cell culture and in animals, debate remains as to whether their main role is actually instructive or permissive in progression to cancer in vivo. "
08/01/2011 - "The efficacy of IGF-I receptor monoclonal antibody against human gastrointestinal carcinomas is independent of k-ras mutation status."
12/01/1993 - "In this study, we have assessed the role of the IGF-1 receptor in the proliferation of ovarian carcinoma cell lines in culture. "
07/01/2012 - "p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy."
06/01/2012 - "BRCA1 is expressed in uterine serous carcinoma (USC) and controls insulin-like growth factor I receptor (IGF-IR) gene expression in USC cell lines."
07/01/2006 - "Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells."
|3.||Osteosarcoma (Osteogenic Sarcoma)
03/15/2009 - "Despite the frequent presence of an insulin-like growth factor I receptor (IGFIR)-mediated autocrine loop in osteosarcoma (OS), interfering with this target was only moderately effective in preclinical studies. "
09/01/2011 - "The novel synthesized 6-fluoro-(3-fluorophenyl)-4-(3-methoxyanilino)quinazoline (LJJ-10) compound exhibits anti-metastatic effects in human osteosarcoma U-2 OS cells through targeting insulin-like growth factor-I receptor."
05/01/2004 - "IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma."
02/01/2004 - "Signal transducer and activator of transcription-1 (STAT1), but not STAT5b, regulates IGF-I receptor gene expression in an osteosarcoma cell line."
03/01/1998 - "These data indicate that the IGF-I receptor is a physiological target for p53 in osteosarcoma cells. "
|4.||Lung Neoplasms (Lung Cancer)
06/05/2007 - "To study the effects of RNA interference (RNAi)-mediated insulin-like growth factor I receptor (IGF-IR) gene silencing on human lung cancer cells. "
01/01/2003 - "Recombinant adenoviruses expressing dominant negative insulin-like growth factor-I receptor demonstrate antitumor effects on lung cancer."
07/01/1996 - "Antitumor effects of an adenovirus expressing antisense insulin-like growth factor I receptor on human lung cancer cell lines."
07/01/1996 - "Insulin-like growth factors (IGFs) are often essential for the maintenance of the malignant phenotype, and in lung cancer the IGF-I receptor (IGF-Ir) is often expressed at high levels. "
08/01/2006 - "Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells."
02/01/2009 - "Insulin-like growth factor-I receptor blockade improves outcome in mouse model of lung injury."
09/01/2012 - "We previously demonstrated that treatment of mice with IGF-1 receptor-blocking antibody (A12) improved early survival in bleomycin-induced lung injury. "
01/01/2013 - "We first examined mice that express αSMA promoter upstream of GFP reporter treated with A12, a blocking antibody to IGF-1 receptor, after bleomycin induced lung injury. "
|1.||Insulin-Like Growth Factor I (IGF-1)
|6.||3- (8- amino- 1- (2- phenylquinolin- 7- yl)imidazo(1,5- a)pyrazin- 3- yl)- 1- methylcyclobutanol
|7.||Fibrinogen (Factor I)
|8.||Antirheumatic Agents (DMARD)
|10.||Insulin-Like Growth Factor II (Somatomedin A)
|1.||Drug Therapy (Chemotherapy)
|2.||Surgical Instruments (Clip)
|3.||Heterologous Transplantation (Xenotransplantation)