Lichen Nitidus

A chronic inflammatory disease characterized by shiny, flat-topped, usually flesh-colored micropapules no larger than the head of a pin. Lesions are localized in the early stages, found chiefly on the lower abdomen, penis, and inner surface of the thighs. Distribution may become generalized as the disease progresses.

Networked: 38 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lichen Planus (Lichen Ruber Planus)
2.	Skin Diseases (Skin Disease)
3.	Darier Disease (Darier's Disease)
4.	Malignant Fibrous Histiocytoma
5.	Syringoma

Experts

1.	Kabashima, Kenji: 2 articles (09/2020 - 11/2010)
2.	Singal, Archana: 2 articles (07/2020 - 04/2019)
3.	He, Yuanmin: 1 article (01/2022)
4.	Liu, Rulan: 1 article (01/2022)
5.	Mao, Hanxiao: 1 article (01/2022)
6.	Pan, Yinghao: 1 article (01/2022)
7.	Wang, Jingying: 1 article (01/2022)
8.	Wei, Guangmin: 1 article (01/2022)
9.	Xiong, Xia: 1 article (01/2022)
10.	Xu, Jixiang: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lichen Nitidus:

1.	Tacrolimus (Prograf)FDA LinkGeneric 11/01/2004 - "Lichen nitidus treated with topical tacrolimus." 11/01/2004 - "The rash was diagnosed as lichen nitidus and was successfully treated with the non-indicated therapy of Protopic 0.1% (Tacrolimus) for 4 weeks." 01/01/2022 - "The patient was diagnosed with lichen nitidus, and tacrolimus cream and humectant were topically administered after diagnosis. " 11/01/2013 - "Persistent generalized lichen nitidus successfully treated with 0.03% tacrolimus ointment."
2.	pimecrolimus (Elidel)FDA Link 06/01/2013 - "Penile lichen nitidus successfully treated with topical pimecrolimus 1% cream." 07/15/2011 - "Letter: Generalized lichen nitidus successfully treated with pimecrolimus 1 percent cream."
3.	B7-H1 AntigenIBA 09/01/2020 - "Upregulated programmed death ligand 1 expression in nivolumab-induced lichen nitidus: A follow-up report with an immunohistochemical analysis."
4.	Hygroscopic AgentsIBA 01/01/2022 - "The patient was diagnosed with lichen nitidus, and tacrolimus cream and humectant were topically administered after diagnosis. "
5.	Itraconazole (Sporanox)FDA LinkGeneric 11/01/1998 - "Six patients with either lichen planus or lichen nitidus were treated with itraconazole. " 11/01/1998 - "Treatment of lichen planus and lichen nitidus with itraconazole: reports of six cases." 11/01/1998 - "Itraconazole, like griseofulvin, may prove to be an alternative treatment worth considering in patients with lichen planus or lichen nitidus who have failed other therapies."
6.	Cetirizine (Zyrtec)FDA LinkGeneric 02/01/1998 - "Generalized lichen nitidus in a child's response to cetirizine dihydrochloride/levamisol."
7.	Hepatitis B Vaccines (Hepatitis B Vaccine)IBA 12/01/2004 - "Lichen nitidus after hepatitis B vaccine."
8.	AcitretinFDA Link 06/01/1994 - "Treatment of palmoplantar lichen nitidus with acitretin."
9.	Interferon-alpha (Interferon Alfa)IBA 01/01/2007 - "It is tempting to speculate that interferon alpha may be involved in the pathogenesis of lichen nitidus." 01/01/2007 - "Generalized lichen nitidus with involvement of the palms following interferon alpha treatment." 01/01/2007 - "Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin. "
10.	AstemizoleIBA 10/01/1990 - "The treatment of lichen nitidus with astemizole."

Therapies and Procedures

1.	Phototherapy (Light Therapy) 05/01/2006 - "Two cases of generalized lichen nitidus treated successfully with narrow-band UV-B phototherapy." 09/01/2019 - "This case demonstrates a rare variant of lichen nitidus and a practical treatment alternative to in-office phototherapy." 09/01/2019 - "We present the rare case of a 6-year-old boy with a 1-year history of generalized lichen nitidus with limited access to narrowband ultraviolet B phototherapy. " 11/01/2010 - "Generalized lichen nitidus successfully treated with narrowband UVB phototherapy." 03/01/2010 - "[Lichen nitidus: favorable response of 2 cases to narrow-band UV-B phototherapy]."
2.	Therapeutics 09/01/2019 - "Pediatric generalized lichen nitidus treated with natural sunlight therapy." 04/01/2019 - "Lichen Nitidus Associated with Onychodystrophy and Response to Therapy: Report of Two Cases." 05/01/2006 - "Narrow-band UV-B may be an effective alternative therapy for the treatment of generalized lichen nitidus unresponsive to common therapies." 03/01/2002 - "This case corroborates previous reports that suggest that generalized lichen nitidus can be successfully managed with ultraviolet light therapy." 05/01/2016 - "We report on a 48-year-old German woman with a flare-up of Darier disease under interferon-α-2a (IFNα-2a) therapy with clinical signs of lichen nitidus. "
3.	Tattooing 01/01/2013 - "Widespread lichen nitidus associated with tattoo." 02/01/1989 - "To detect LZ in these cells morphologically, I have done electron microscopic observations of the following skin diseases; sarcoidosis, lupus vulgaris, lupus miliaris disseminatus faciei (LMDF), tattoo granuloma, lichen nitidus, foreign body granuloma, granuloma annulare, xanthelasma, xanthoma tuberosum, xanthoma planum, juvenile xanthogranuloma, giant cell tumor of tendon sheath, dermatofibroma, malignant fibrous histiocytoma, dermatofibrosarcoma protuberans, granulation tissue of burn, hypertrophic scar, and histiocytosis X. From both the immunohistochemical and the electron microscopic features it was concluded that a) immunohistochemically LZ-positive cells from lesions of sarcoidosis, lupus vulgaris, LMDF and tattoo granuloma had a number of electron-lucent bodies (ELB) or microvesicles in their cytoplasm, b) lichen nitidus and xanthoma tuberosum had few LZ-positive cells and the ELB were not observed, and c) the other diseases were LZ-negative, and the ELB were also absent. "
4.	Photochemotherapy (Photodynamic Therapy) 06/01/1986 - "The similarity of lichen nitidus to lichen planus and the presumed lymphocytotoxic effect of PUVA were the bases for our use of oral photochemotherapy."
5.	Lasers (Laser) 01/01/2011 - "In vivo imaging of lichen nitidus with confocal laser scanning microscopy."